In field studies conducted over two years, soybean cultivars ‘Deltapine 415’, ‘Forrest’, ‘Asgrow 6785’, ‘Centennial’, 'Sharkey’, ‘Terra Vig 616’, ‘Hartz 6686’, and ‘Pioneer 9791’ responded similarly to POST application of AC 263,222. With supplemental overhead irrigation of 5.1 cm weekly for 4 wk initiated 21 d after herbicide applications, mature soybean height for the cultivars averaged 18% less than that of the untreated check for 27 g/ha AC 263,222, but only 8% less when not irrigated. Although nonirrigated soybean seed yield following AC 263,222 application the first year was not reduced compared with the untreated check, with irrigation seed yield reductions of 12 and 32% were noted for 13 and 27 g/ha AC 263,222, respectively. Seed yield the second year was not negatively affected with herbicide application whether soybean was irrigated or not irrigated. For individual years, seed yield for the untreated irrigated and nonirrigated checks was similar. In the first year soybean yield following AC 263,222 at 13 and 27 g/ha with irrigation was 16 and 30% lower, respectively, than when soybean was not irrigated. Decreases in soybean 100-seed weight accompanied the yield reductions.