This paper deals with the coupled chemotaxis-haptotaxis model of cancer invasion given by
where χ, ξ and μ are positive parameters and Ω ⊂ ℝn (n ≥ 1) is a bounded domain with smooth boundary. Under zero-flux boundary conditions, it is shown that, for any μ > χ and any sufficiently smooth initial data (u0, w0) satisfying u0 ≥ 0 and w0 > 0, the associated initial–boundary-value problem possesses a unique global smooth solution that is uniformly bounded. Moreover, we analyse the stability and attractivity properties of the non-trivial homogeneous equilibrium (u, v, w) ≡ (1,1, 0) and establish a quantitative result relating the domain of attraction of this steady state to the size of μ. In particular, this will imply that whenever u0 > 0 and 0 < w0 < 1 in there exists a positive constant μ* depending only on χ, ξ, Ω, u0 and w0 such that for any μ < μ* the above global solution (u, v, w) approaches the spatially uniform state (1, 1, 0) as time goes to infinity.