Repeated supernovae from an OB association will, in a few ×107 yr, create a cavity of coronal gas in the interstellar medium, with radius > 100 pc, surrounded by a dense expanding shell of cool interstellar gas. Such a cavity will likely burst through the gas layer of a disk galaxy. Such holes and “supershells” have been observed in optical and H I radio emission maps of the Milky Way and other nearby galaxies. The gas swept up in the supershell is likely to become gravitationally unstable, providing a mechanism for propagating star formation that may be particularly effective in irregular galaxies.