Problem of malignant tumors is one of leading for modern society due to large prevalence and lethality of these diseases in Russia. In this association, increasingly greater relevance is acquired by problem of diagnostics of nosogenias and rehabilitation of patients with nosogenic reactions.

In our investigation, sample included 30 patients at the age from 28 to 71 years (in average 49,7±11,1 years) with diagnosis “breast cancer” at Russian Oncological Scientific Center in pre- and post surgery period of radical mastectomy.

Average length of disease at baseline has constituted 6,8±1,2 months. In all studied cases, nosogenic reactions flew at two stages - manifestation and clinical differentiation. At stage 1 - manifestation - in all studied female patients, acute (“universal”) affective reaction developed (reaction of apparent death - according to E. Kretschmer). At stage 2 clinically differentiated reaction of one of 4 types formed: anxiety-depressive, anxiety-dissociative, anxiety-phobic and hypomaniacal. Anxiety-dissociative reaction formed predominantly in patients with hysteric personality disorder. Anxiety-phobic was more typical for persons with anxiety-avoidant personality disorder. Hypomaniacal nosogenic reaction was revealed in female patients with combined schizoid traits and schizotypal personality disorder (group of expansive schizoids). Peculiarity of these patients is signs of hyponosognosia in family history that explains seeking the oncologist at remote stages of disease (stage IIIIV of breast cancer at admission).

For more successful therapy and rehabilitation of patients with breast cancer it is necessary to develop differentiated indications of psychopharmacotherapy of nosogenic disorders in this diseases.

Positive affect (PA) is correlated to several positive outcomes and might be a constituent of happiness (Lyubomirsky et al., 2005).

To investigate the correlates of PA in pregnancy and postpartum.

397 pregnant women (T0) were also followed at 3 months postpartum (T1). At both time-points, they completed a questionnaire, the Postpartum Depression Screening Scale (PDSS), the Profile of Mood States (POMS), and were also interviewed with some sections of the Diagnostic Interview for Genetic studies (DIGS). Descriptive and correlation analyses were performed.

T0/T1 PA scores were correlated (p< .01). T0 PA was associated with fewer children, and T1 PA with a concurrent better self-reported health (p< .05). PA at T0/T1 was associated with nulliparity (p< .05/p< .01), mother's age (younger) (p< .05/p< .01). PA at T0/T1 was associated with lower levels of perceived life stress (p< .01); better life quality (p< .01); more social support (p< .01); lower levels of anxiety trait, depressive/anxious emotional states (p< .01), depressive symptoms (p< .01), and suicide ideation (p< .01); less self-reported maternal sleep difficulties and lower interference of it on their mood and working functioning. Moreover, PA assessed at pregnancy was associated with these variables at postpartum. PA at T1 was associated with a better perception of the infant as having less feeding/sleeping/and behavior problems.

PA is a protective emotional trait, a good indicator of physical/mental health, and well-being in perinatal period. Mother's PA influences her perception of the infant temperament and may contribute positively to the dyadic interaction.

The project “The Oldest Old: Coimbra aging study”’ (PTDC/CS-SOC/114895/2009) will be carried out based on an elderly population enrolled in Health Centers of the Municipality of Coimbra, Portugal. One of the areas in study is the mental health. This approach is complex due to the effects caused by changes occurring throughout life.

Evaluate the mental health status of Coimbra's elderly population applying the OARS/QAFMI (Older Americans Resources and Services/ Questionário de Avaliação Funcional Multidimensional para Idosos) questionnaire.

Assess the use and need felt for health services and social support by the elderly, related with their functional status in mental health.

Quantitative methodology using the QAFMI/OARS. The sample consisted of individuals aged 75, or more, randomly selected and representative of Coimbra's elder residents, to achieve 10% of the population. Their mental health status was evaluated using the Short Portable Mental Status Questionnaire (SPMSQ), the Short Psychiatric Evaluation Schedule (SPES) and a self-evaluation.

The preliminary results showed that the majority of the individuals had scored a “good mental health” status. The female had tendentiously lower scores of the mental health status than the males with the same age. The oldest individuals (≥85 years old) had also scored lower results than the ones with 75-84 years old.

The results obtained with the OARS/QAFMI indicated a cognitive decline, with differences between gender and age of the individuals being the females and oldest individuals the ones to score the worst mental status.

Neurocognitive impairments are a core feature of schizophrenia. The medial temporal lobe (MTL) is a brain region associated with declarative memory important in conscious acquisition and recollection of facts and events. The basal ganglia (BG) instead are linked to non-declarative memory functions such as gradual learning of skills and habits.

Acquired equivalence (AE) is a phenomenon in which prior training to treat two stimuli as an equivalent increases generalization between them. Our objective was to study this phenomenon in birth cohort setting.

To investigate whether the recall of previously learned associations and memory generalization are declined in schizophrenia, other psychoses and siblings compared to healthy controls.

The Northern Finland Birth Cohort 1966 is based upon 12, 068 women and their 12, 058 live-born children. The modified Rutger's AE-task was performed for 35 schizophrenia patients, 26 patients suffering from other psychosis, 18 siblings of psychotic subjects and 174 controls.

The behavioral data showed statistically significant impairment in both recall of learned associations and generalization in schizophrenia and other psychosis groups compared to control subjects. Siblings did not differ significantly from controls in recall of learned associations but they showed impairments in generalization.

Impairment in recall of learned associations and memory generalization seem to be present also in other psychotic disorders, not only in schizophrenia. Since decline in generalization was seen in addition in siblings the hypothesis that declarative memory could be one of endophenotypes of schizophrenia is supported by this study.

In 2007 the Mental Health Act in England and Wales was amended and the definition of Mental Disorder was broadened. This change affected people with Personality Disorders who now can be admitted for hospital treatment without consent, often for prolonged period of time.

This poster reviews patients’ attitudes towards the new legislation and its consequences and also presents the research on the different perspectives about the new law.

To review patients’ attitudes with regard to interfaces between Personality Disorders and the new law.

Use of the specifically designed questionnaire for patients with Borderline Personality Disorders hospitalized under Mental Health Act. MEDLINE and PsycINFO databases were also searched for all English-language articles published between 2008 and 2012 containing the keywords “Personality Disorder”, “Mental Health Act” and “patients’ view on compulsory treatment”. Additional key articles published before 2008 were reviewed. The most relevant articles were selected for review.

There is still no common consensus in regard to the benefit of compulsory hospital admission of persons with Borderline Personality Disorders. Results from questionnaires are under review.

Social intolerance is one major topic in every modern society, but although it receives much attention in the public space, there is relatively little information related to the behavioral correlates of such attitudes.

To investigate the relation between social intolerance and risk-taking behaviors in European adolescents.

Adolescents from the SEYLE and WE-STAY cohorts were included. The questions evaluating social intolerance, sensation-seeking and delinquent behavior, alcohol, tobacco and illegal drugs use were extracted from the baseline questionnaire.

Adolescents positive for at-risk tobacco, alcohol and illegal drugs use showed significantly lower levels of social intolerance. This observation might be explained by the social factors associated with substance use at this age group. No relationship was observed with sensation-seeking and delinquent behavior.

Social intolerance is not associated with risk-taking behaviors in adolescents.

There are a number of clinical scores to measure cognitive impairment and behavioral and psychological symptoms of dementia (BPSD) for dementia patients.

Previous BPSD scores are well established, but they usually take long time. Furthermore they were made almost 20 years ago, and therefore may not even fit a current BPSD because affective expressions may change depending on modern society change.

To make a new and simple score which fits modern change of BPSD.

Based on BPSD inquiry from 129 caregivers in local area (patients 81.6 ± 9.9 years old and female 70.5%), a new and simple BPSD score was created, and compared to standard BPSD score NPI (neuropsychiatry inventory). Time was measured to complete this new BPSD score (ABS, Abe's BPSD score) and NPI. This ABS was examined before and after a choline esterase inhibitor treatment.

We gave final scores to each BPSD items with such temporal frequencies taken into account ranging 0-9, and finalized a new BPSD score of score 0-44 between no BPSD to full BPSD. Average time to complete both NPI and ABS was 308.9 ± 86.3 sec and 46.5 ± 16.2 sec (**p< 0.01), respectively. Galantamine showed an improvement of average ABS with - 2.3 ± 1.0 (*p< 0.05) from original score of 6.1 ± 6.6 after 3 month of the treatment.

These data suggest that this new and simple BPSD score (ABS) may be beneficial to quickly evaluate BPSD before and after a treatment of dementia patients.

Family burden is considered to be an integrated psychosocial parameter negatively impacting on symptom levels, social functioning and outcomes of children and adolescents with schizophrenic spectrum disorders, and specific measures directly aimed at lessening the burden of these families should be developed.

To assess the influence of burden-focused group therapy (BFGT) with parents on social functioning of children and adolescents with schizophrenic spectrum disorders.

Parents of 126 children with administered standard antipsychotic therapy (aged 8 - 17 years) were recruited into this study. Parents were assigned to eight 90-minutes “module” structured sessions carried out in groups (8 - 9 members) and received a systematic assessment using CGSQ and CGAS at entry and after 1, 3 and 6 month.

Reciprocal effect with negative correlation (r=-0.463, P=0.005) between family burden indicators and children's total levels of functioning was established. BFGT did significantly affect family burden and correlated with positive changes in overall levels of social functioning of children using CGAS (p< 0,05). The largest decline was noted in Subjective burden (from 4.98 to 3.75).

BFGT aimed at managing family burden and improving children's social functioning proved to be one of key components of the psychosocial treatment and rehabilitation of children and adolescents with schizophrenic spectrum disorders in the context of increasing rehabilitation resource of their families. Further controlled studies are required to strengthen the evidence base for effective management of family burden.

Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcome in schizophrenia. The long DUP and its relation to poor short-term outcome of schizophrenia has been studied in meta-analyses, but the conclusions remain unclear regarding the long-term effects of DUP.

To study the association between DUP and long-term outcome in a meta-analysis.

A systematic literature search of studies on DUP and long-term outcome in schizophrenia was performed using seven electronic databases. Studies were included if the follow-up was at least two years, the majority of subjects had a diagnosis of schizophrenia and DUP was studied with at least one of the following outcome categories: positive, negative, general and total symptoms, need of treatment, social functioning, employment, global outcome, quality of life and remission. Random effect methods were used to pool the effects of original studies.

2636 unique publications were identified of which 37 met our pre-defined selection criteria. Long DUP correlated with more severe positive (number of studies n=16; r=0.17), negative (n=17; r=0.14), general (n=4; r=0.29) and total symptoms (n=7; r=0.14) and with poor social functioning (n=13; r=0.13), poor global outcome (n=15; r=0.22) and less likely remission (n=16; r=0.14). The association between long DUP and decreased need of treatment was close to statistical significance (n=12; r=0.12). Employment (n=5) and quality of life (n=5) were not associated with DUP.

Severe symptoms and decreased functionality does not seem to increase the need of treatment or decrease the quality of life or employment.

Effective and safe prescription of individualized opioid-doses for opioid-dependent is a complicated task for the clinician, due inter-individual differences in dosage requirements and narrow therapeutic range.

Mu-opioid receptor gene (OPRM1) plays a key role in addiction. A118G-rs1799971 polymorphism in OPRM1 is probably the most promising biomarker of better response in opioid-dependents.

Gene polymorphisms in CYP450-isoenzymes (CYP3A5, CYP3A4, CYP2D6, CYP2B6, CYP1A2, CYP2C9 and CYP2C19) also significantly influence pharmacokinetics and effects of opioids and concomitant treatments.

Association of heroin-dose requirements to OPRM1-rs1799971, CYP3A4-rs2740574 and CYP3A5- rs776746 gene polymorphisms in patients from a Heroin Prescription Program (PPH) in Andalusia.

Series of cases: 15 patients with opioid-addiction. Collection of heroin-doses/patient administered for a year. Genotyping of A118G, CYP3A4 and CYP3A5 polymorphisms was performed by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism.

Eleven patients were AA homozygous (11/15;73.33%) and four heterozygous AG (4/15;26.67%) for A118G-OPRM1; median doses: 179.57[157.85,225.49] and 271.38[145.11,288.88]mg/day respectively were no statistically different (p=0.240). Four subjects presented doses>250mg/day, showing an association of AG-OPRM1 genotype with higher doses, OR:30.00(CI95%:1.41,638.15);p=0.033.

Fourteen patients were homozygous AA and GG for CYP3A4 and CYP3A5 respectively (14/15;93.33%), and one patient was heterozygous AG(1/15;6.66%) for both isoenzymes and presented a high dose(280 mg/day).

Higher heroin-doses (>250mg/day) were associated to AG genotype for OPRM1-A118G, despite the great variability in the dose prescription avoided to find an association between OPRM1 genotype and the specific administered dose.

Pharmacogenetic analysis, focused on OPRM1-A118G, may be a useful tool to adjust the pharmacotherapeutic dose in each case.

Interferon-alpha (IFN-α) and Ribavirin is the recommended treatment for chronic hepatitis C (CHC). Common treatment side-effects include neuropsychiatric symptoms such as anxiety, which impairs patient's quality of life and treatment adherence. Inflammation and neurotransmission systems may play a role in the pathogenesis of IFN-α-induced anxiety. The GC/GG genotype at a polymorphism located in the interleukin-6 synthesizer gene (IL6 gene) has been related with a higher production of IL-6 and “higher inflammation response”. A polymorphism in the serotonin transporter gene (SERT) has been related with anxiety and antidepressant response. The aim of the study was to assess the role of IL6 and SERT polymorphisms as predictive variables of IFN- induced anxiety.

A cohort of 385 Caucasian outpatients with CHC initiating antiviral treatment. Patients were euthymic and without current anxiety disorder (SCID) at baseline. Anxiety evaluation: Hospital anxiety and depression scale. Assesment: Baseline, 4, 12, 24, and 48 weeks after antiviral treatment initiation. DNA was extracted and polymorphisms genotyped. Hardy- Weinberg equilibrium: IL-6 (p=0.72) and SERT (p=0.41). Statistical analysis: linear mixed-effects.

Patients carrying the G allele (GC/GG genotype) of IL6 polymorphism (G vs. CC) had more anxiety symptoms (p=0.004) during antiviral treatment. We did not find a significant effect of SERT (S vs. LL) on anxiety (p=0.15). No significant interaction between both genes was reported.

GC/GG genotype, that implies higher seric concentrations of IL6, predicts interferon-α-induced anxiety supporting a role of inflammatory pathway on pathophysiology of anxiety.

PSICOCIT-VHC-P110/01827, and PSIGEN-VHC-EC08/00201. ERDF, European Union “One way to make Europe”.

Several studies evaluated the effects of changes in a price on various outcomes related to harmful alcohol consumption, including alcohol dependence, known to be specifically attributed to long-term alcohol abuse.

Against this background, it would be interesting to evaluate the relationship between alcohol affordability and alcohol dependence prevalence rates in post-Soviet Belarus.

To examine the relation between alcohol affordability and alcohol dependence prevalence in Belarus between 1990 and 2010 regression analysis was performed using the statistical package “Statistica”.

In the period from 1990 to 2010 the prevalence of alcohol dependence in Belarus increased by 42,7% (from 1419,1 to 2024,4 per 10.000 of the population). The affordability of alcohol has increased significantly since the early 1990s: the average salary in 1993 could by 7.3 litres of vodka compared with 73.9 litres in 2010. The results of time series analysis suggest positive association between alcohol affordability and alcohol dependence prevalence rates: a 0.3% increase in the prevalence of alcohol dependence rate following a 1% increase in affordability of alcohol.

The results from this study are consistent with previous findings suggesting a significant association between alcohol affordability and alcohol-related problems. The main reason for the growth of alcohol consumption and alcohol-related problems in Belarus was the liberalization of the alcohol policy and increase in the affordability of alcohol. Hence, to prevent a further increase of alcohol affordability, increases alcohol prices seems to be one of the priority options of alcohol control policy in Belarus.

Adolescents still lack knowledge about depression and its treatment. As a result, depressed adolescents are confronted with stigmata that are barriers to treatment-seeking. Studies in adults demonstrated that depression literacy can be increased by educational material.

We developed an information booklet on depression specifically addressing adolescents aged 13 to 17. For the first time, it was examined whether knowledge about depression in youth can be enhanced by reading an educational leaflet.

The information booklet was evaluated in 628 German ninth graders (M= 15.1 years, 58% boys) in a pre-postfollow- up design.Using study-specific questionnaires, knowledge about seven topics on depression was assessed. Key subjects were symptoms and treatment of depression as well as suicidality.In addition, students evaluated the booklet's layout, content and utility.

Power-analysis of the pre-post-follow-up-comparison yielded effect sizes of knowledge enhancement between eta2 = 0.07 (medium) and 0.56 (large) for all topics of the booklet.The largest effect sizes were found for the topics “symptoms” and “antidepressants”. Sub-analysis on school types and gender showed the highest increase in knowledge in well-educated students and in girls. The participating youth assessed the booklet positively regarding all categories, with a mean overallrating of 2.15 on a scale from 1 (very good) to 6 (fail).

Although students’ baseline knowledge about depression was good, girls and boys of all school types significantly increased depression literacy. Thus, the booklet can help reducing stigmata and treatment barriers in adolescents.

Described since the 19th century, menstrual psychosis is considered a forgotten disorder. Current classification systems do not include the diagnosis of menstrual psychosis, a condition comprising in psychotic episodes recurring during each menstrual or premenstrual period, but remitting the rest of the month. The world literature consists mainly of case reports. To our knowledge this is the first Romanian report of menstrual psychosis.

To describe the course of the condition in a patient with multiple and rapid recurring psychotic episodes from onset until the most recent hospitalization.

To better understand if this case could be considered a true menstrual psychosis.

Review of the medical charts of the 57 hospitalizations the patient has had between 1977 and 2012 in the “Prof. Dr. Al. Obregia” Psychiatry Hospital.

Initial diagnosis included discordant psychosis and atypical depressive state that shifted in time to schizoaffective disorder and various forms of schizophrenia. The history reveals cyclic episodes with short-term remissions and multiple hospitalizations. Treatment approaches also varied during the course of the disease, from ECT to second generation of antipsychotics without any consistent long-term remission. The frequency of episodes started to dramatically reduce only when the menopause installed.

Patients with a history of numerous admissions might benefit from a record review aimed at identifying temporal patterns. Clinicians should be aware of menstrual psychotic symptoms exacerbations in a minority of women with chronic mental disorders and therapeutic strategies need to be carefully considered and adjusted to each individual patient.

WAVE-bd provides information on the clinical management and outcomes of BDI and II patients in daily clinical practice.

To describe French patients (n=480) clinical outcomes up to 18 months.

WAVE-bd included patients with ≥1 mood event (index episode) in the preceding 12 months before inclusion and followed ≥ 9 months (total participation 12 to 27 months).

2896 patients were analysed worldwide, 17% in France (53% in private practice, 47% in public practice): mean age 47 years (SD: 12.51), women, 65%; BD-I, 59%; BD-II, 41%; index event depressive, 64%; hypomanic, 21%; manic, 9%; mixed, 6%.

During follow-up, 77 patients (16%) reported relapses (1.25 patient-years; 95%CI = [1.04; 1.49]) and 176 patients (37%) reported recurrences (0.65 patient-years; 95%CI = [0.57; 0.74]). The most common type of reported recurrence (n; %) was depressive (114; 24%) rather than hypomanic (64; 13%), manic (14; 3%) or mixed (11; 2%). Suicide attempt was reported in 25 patients (5,2%, 0.046 patient-years; 95%CI=[0.031;0.064]). The most common type of treatment during manic and hypomanic episodes was atypical antipsychotics AAP (69% and 49%, respectively) while during depressive episodes, the most common types of treatment were antidepressants (82%).

These results show a high incidence of relapse and recurrence of mood events and the more frequent depressive polarity in BD patients in France. Further analyses are required to evaluate which factors influenced the severity (relapse, recurrence and suicidality) of the disease. Overall, antipsychotics and antidepressants were most commonly prescribed for manic and depressive episodes, respectively.

The child pornography collecting process and the way the pornographer considers his collection need to be better understood. It is these psychopathological issues and the risk of the person acting out his fantasies that need to be analyzed.

We want to understand the phenomenon of child pornography, because it is sometimes a matter of deviance without leading to actual abuse.

The aim of our study is thus to identify the characteristics of people who download child pornography.

We collected datas from forensic psychiatric assessments. The criterion for inclusion was the possession of pornographic images of minors. We studied pathological characteristics of this sample.

Subjects were almost exclusively male with an average age of forty years. They have generally a good academic level. A significant difference is observed between the childhood aspects of child pornographers, sex online and offline offenders. A sense of loneliness is expressed in 32.8%.

Child generally fulfills a fantasy of a pedophile nature. Different profiles of child pornographers have been proposed which are not always related to pedophilia. Our study has permitted to have informations about the sexuality of child pornographers. The feel to not be well integrated could explain the use of virtual mean of telecommunication. Clinical differences can be made between child pornographers and sex online offenders.

Full findings from the European Commission funded EU-NET-ADB study (Safer Internet Programme) will be presented.

Empirical findings that elucidate the development of an internet addictive behaviour are still incomplete. This is also related to risk as well as protective factors of internet use. Here a process oriented approach to identify underlying conditions of an internet addictive behaviour was chosen.

The aim of the study is to enhance the knowledge and understanding of underlying processes which lead to situation were internet addictive behaviour can evolve.

In total 124 in-depth interviews were conducted with adolescents with an age of 14-17 year. Adolescents from seven different European countries (Greece, Spain, Poland, Germany, Romania, Netherlands & Iceland) participated in this study. Eligibility was granted when adolescents scored more than 30 point or equal in the Internet Addiction Test (IAT; Young, 1998). Data analysis was conducted by use of a step-wise full version of Grounded Theory (Strauss & Corbin, 1990; 1998).

Adolescents employed maladaptive and adaptive strategies in regard to their involvement in the internet. Thus different Digital Outcomes such as “I am addicted” (Stuck Online) ranging to more adaptive internet behaviour like (Juggling it All) and patterns of self-correcting (Coming Full Cycle) were identified. These Digital Outcomes were consequently linked to adolescent's developmental pathways and can be characterized by the core category “Navigating Adolescent Pathways”.

Contextual and developmental factors that mediate the development of an internet addictive behaviour could be identified and linked to multiple Digital Outcomes.