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1646 – Genetic Risk Factors For Interferon-induced Anxiety

Published online by Cambridge University Press:  15 April 2020

M. Udina ,
J. Moreno-España ,
R. Navinés ,
K. Langohr ,
M. Gratacós ,
X. Forns ,
L. Capuron ,
E. Vieta ,
R. Solà  and
R. Martín-Santos
M. Udina
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
J. Moreno-España
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
R. Navinés
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
K. Langohr
Affiliation:
Statistic Department, Universitat Politècnica de Catalunya
M. Gratacós
Affiliation:
Center of Genomic Regulation, PRBB
X. Forns
Affiliation:
Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain
L. Capuron
Affiliation:
Laboratory of Nutrition and Integrative Neurobiology, NutriNeuro, INRA UMR 1286, University Victor Segalen, Bordeaux, France
E. Vieta
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM
R. Solà
Affiliation:
Hepatology Unit, Hospital del Mar, IMIM, Barcelona, Spain
R. Martín-Santos
Affiliation:
Department of Psychiatry, Institute of Clinical Neuroscience, Hospital Clínic, UB, IDIBAPS, CIBERSAM

Abstract

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Background/aims

Interferon-alpha (IFN-α) and Ribavirin is the recommended treatment for chronic hepatitis C (CHC). Common treatment side-effects include neuropsychiatric symptoms such as anxiety, which impairs patient's quality of life and treatment adherence. Inflammation and neurotransmission systems may play a role in the pathogenesis of IFN-α-induced anxiety. The GC/GG genotype at a polymorphism located in the interleukin-6 synthesizer gene (IL6 gene) has been related with a higher production of IL-6 and “higher inflammation response”. A polymorphism in the serotonin transporter gene (SERT) has been related with anxiety and antidepressant response. The aim of the study was to assess the role of IL6 and SERT polymorphisms as predictive variables of IFN- induced anxiety.

Material/methods

A cohort of 385 Caucasian outpatients with CHC initiating antiviral treatment. Patients were euthymic and without current anxiety disorder (SCID) at baseline. Anxiety evaluation: Hospital anxiety and depression scale. Assesment: Baseline, 4, 12, 24, and 48 weeks after antiviral treatment initiation. DNA was extracted and polymorphisms genotyped. Hardy- Weinberg equilibrium: IL-6 (p=0.72) and SERT (p=0.41). Statistical analysis: linear mixed-effects.

Results

Patients carrying the G allele (GC/GG genotype) of IL6 polymorphism (G vs. CC) had more anxiety symptoms (p=0.004) during antiviral treatment. We did not find a significant effect of SERT (S vs. LL) on anxiety (p=0.15). No significant interaction between both genes was reported.

Conclusion

GC/GG genotype, that implies higher seric concentrations of IL6, predicts interferon-α-induced anxiety supporting a role of inflammatory pathway on pathophysiology of anxiety.

Grants

PSICOCIT-VHC-P110/01827, and PSIGEN-VHC-EC08/00201. ERDF, European Union “One way to make Europe”.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E924
Copyright
Copyright © European Psychiatric Association 2013
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