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The effects of compressibility on the statistics and coherent structures of a temporally developing mixing layer are studied using numerical simulations at convective Mach numbers ranging from $M_c=0.2$ to $1.8$ and at Taylor Reynolds numbers up to 290. As the convective Mach number increases, the streamwise dissipation becomes more effective to suppress the turbulent kinetic energy. At $M_c=1.8$, the streamwise dissipation increases much faster than the other two components in the transition region, even larger than pressure–strain redistribution, correlating with the streamwise elongated vortical structures at a higher level of compressibility. We confirm the existence of the large-scale high- and low-speed structures in the mixing layers, which accompany the spanwise Kelvin–Helmholtz rollers at low convective Mach number and dominate the mixing layer at higher convective Mach number. Conditional statistics demonstrate that the large-scale low-speed structures are lifted upwards by a pair of counter-rotating quasi-streamwise rollers flanking the structures. The small-scale vortical structures have an apparent preference for clustering into the top of the low-speed regions, which is directly associated with high-shearing motions on top of the low-speed structures. The high-speed structures statistically exhibit central symmetry with the low-speed structures. The statistics and dynamics of large-scale high- and low-speed structures in the compressible mixing layers resemble those in the outer region of the turbulent boundary layers, which reveals the universality of the large-scale structures in free shear and wall-bounded turbulence. A conceptual model is introduced for the large-scale high- and low-speed structures in turbulent mixing layers.
The finite-amplitude instability of the buoyancy-driven boundary layer is considered on a vertical plate immersed in a thermally stratified ambient medium, where the wall and surrounding fluid have different temperature gradients. Although the linear stability in this configuration has been investigated, the finite-amplitude solution arising from the critical instability has been studied only for specific parameter values. We extend this by using the amplitude expansion method. The primary bifurcations to the two-dimensional least unstable mode for different temperature gradient ratios ($0 \leqslant \lambda \leqslant 10$) and Prandtl numbers ($10^{-1} \leqslant Pr \leqslant 10^{4}$) are investigated. Only supercritical bifurcations are found to occur when $0 \leqslant \lambda < 2$ and $Pr \leqslant 2800$, while subcritical bifurcations are also found for larger values of temperature gradient ratio and Prandtl number. Analysis of the contribution of the nonlinear terms in the Landau coefficient reveals that the interaction of the modification of the mean flow and second harmonic for velocity with the fundamental mode for temperature plays an important role in subcritical bifurcation. Based on the Landau equation, the threshold amplitude of the nonlinear equilibrium solution is discussed as well. These encouraging results should be helpful for understanding such a buoyancy-driven flow system.
We derive from first principles analytic relations for the second- and third-order moments of $\boldsymbol{\mathsf{m}}$, the spatial gradient of fluid velocity $\boldsymbol{u}$, $\boldsymbol{\mathsf{m}} = \nabla \boldsymbol{u}$, in compressible turbulence, which generalize known relations in incompressible flows. These relations, although derived for homogeneous flows, hold approximately for a mixing layer. We also discuss how to apply these relations to determine all the second- and third-order moments of the velocity gradient experimentally for isotropic compressible turbulence.
In this study, we present a three-dimensional numerical model for the interaction of flow with submerged flexible vegetation, based on a large-eddy simulation and the immersed boundary method. The model innovatively realises the interaction between the flow and highly flexible vegetation with clustered leaves. Besides being a three-dimensional model of motion with full degrees of freedom, this study improves the consideration of the motion of the vegetation in all directions, and in addition the energy and momentum transfer in the spanwise direction. Furthermore, we perform a flume experiment for the flow with submerged flexible vegetation, the results of which are used to validate the simulation effects of the numerical model. It is found that the numerical model can effectively simulate the velocity profiles and the movement of vegetation induced by the flow. Using the model to analyse the flow–vegetation interaction, we find that the movement of vegetation is closely related to the flow velocity. As the flow velocity increases, both the offset angle and the vegetation swaying amplitude increase. Compared to vertical rigid vegetation, the tilting of flexible vegetation does not significantly change the velocity difference and the magnitude of the turbulent kinetic energy between the inside and the outside of the vegetation canopy, but it does weaken the disturbance to flow, thus reducing the resistance to flow. However, the swaying of vegetation dose significantly increase the velocity difference between the inside and the outside of the canopy. It forms Kelvin–Helmholtz hairpin vortices intensifying the turbulence production, and enhancing the disturbance and resistance to flow.
Biomolecular recognition including binding of small molecules, peptides and proteins to their target receptors plays a key role in cellular function and has been targeted for therapeutic drug design. However, the high flexibility of biomolecules and slow binding and dissociation processes have presented challenges for computational modelling. Here, we review the challenges and computational approaches developed to characterise biomolecular binding, including molecular docking, molecular dynamics simulations (especially enhanced sampling) and machine learning. Further improvements are still needed in order to accurately and efficiently characterise binding structures, mechanisms, thermodynamics and kinetics of biomolecules in the future.
Spectral observations with high temporal and frequency resolution are of great significance for studying the fine structures of solar radio bursts. In addition, it is helpful to understand the physical processes of solar eruptions. In this paper, we present the design of a system to observe solar radio bursts with high temporal and frequency resolutions at frequencies of 25–110 MHz. To reduce the impact of analog devices and improve the system flexibility, we employ various digital signal processing methods to achieve the function of analog devices, such as polarisation synthesis and beamforming. The resourceful field programmable gate array is used to process radio signals. The system has a frequency resolution of
$\sim$
30 kHz and a temporal resolution of up to 0.2 ms. The left/right circular polarisation signals can be simultaneously observed. At present, the system has been installed at Chashan Solar Observatory operated by the Institute of Space Science, Shandong University. The system is running well, multiple bursts have been observed, and relevant data have been obtained.
We report the experimental results of the commissioning phase in the 10 PW laser beamline of the Shanghai Superintense Ultrafast Laser Facility (SULF). The peak power reaches 2.4 PW on target without the last amplifying during the experiment. The laser energy of 72 ± 9 J is directed to a focal spot of approximately 6 μm diameter (full width at half maximum) in 30 fs pulse duration, yielding a focused peak intensity around 2.0 × 1021 W/cm2. The first laser-proton acceleration experiment is performed using plain copper and plastic targets. High-energy proton beams with maximum cut-off energy up to 62.5 MeV are achieved using copper foils at the optimum target thickness of 4 μm via target normal sheath acceleration. For plastic targets of tens of nanometers thick, the proton cut-off energy is approximately 20 MeV, showing ring-like or filamented density distributions. These experimental results reflect the capabilities of the SULF-10 PW beamline, for example, both ultrahigh intensity and relatively good beam contrast. Further optimization for these key parameters is underway, where peak laser intensities of 1022–1023 W/cm2 are anticipated to support various experiments on extreme field physics.
Based on the chemical reaction model proposed by Park, the ‘blackout’ of a reentry vehicle is studied in this paper. The temperature, pressure and electron density distribution characteristics around the reentry vehicle were simulated at various flight speeds and altitudes by USim. Subsequently, the scattering matrix method was used to study the transmission characteristics of terahertz waves in ‘blackout’. The simulation results show that the temperature around the aircraft is mainly affected by speed, the pressure is mainly affected by the altitude and electron density is affected by both of these factors. The calculation results show that the transmission characteristics of terahertz waves in plasma are mainly affected by electron density, while the effects of temperature and pressure cannot be ignored either.
In offshore offloading operations, two vessels in a side-by-side configuration experience actions of both ambient water waves and liquid sloshing in internal tanks. Under the excitation of water waves, complex multibody motions are induced, resulting in liquid sloshing in tanks, and concurrently liquid sloshing can feedback to affect the vessels’ motions. The interaction between waves and two barges in a side-by-side configuration coupled with liquid sloshing effects is investigated for a fixed–free arrangement. A numerical model is developed based on the boundary element method to deal with complex wave induced multibody motions coupled with liquid sloshing in internal tanks. Due to the presence of a narrow gap between two vessels, gap resonance may occur, and a damping surface is introduced to suppress an unrealistic response near resonance. Concurrently, physical experiments with and without liquid sloshing effects are carried out. In-depth discussions on motion characteristics are given, and Stokes and non-Stokes natural frequencies associated with liquid sloshing are discussed. The significance of the present study is twofold. Firstly, the experimental measurements provide reference results for validations of numerical simulations. Secondly, this work gives an insight into wave induced motions with liquid sloshing effects under different wave headings which affect vessel operational safety.
Based on self-consistent modelling of the radio-frequency sheath parameters, such as the ion and electron densities and the ion velocity, the dust particle charging process in an RF sheath is investigated by employing the kappa $(\kappa )$ distribution for the electrons. It is shown that the charge number of the dust particle decreases near the sheath–wall interface while it shows the opposite tendency near the plasma-sheath edge, as the $\kappa$ value is decreased. The fluctuation of the dust particle charge modified by the $\kappa$ value depends on the dust particle radius. With an increases in the $\kappa$ value, the fluctuation of the dust particle charge has a slight increase for a small dust particle, and it shows a significant increase for a large dust particle. In addition, as the $\kappa$ value is decreased, the charge number of the dust particle obtained from the time-averaged plasma parameters deviates from the results obtained from the instantaneous plasma parameters. Moreover, a smaller deviation can be found for a large dust particle under the same $\kappa$ value conditions.
The topological Langmuir-cyclotron wave (TLCW) is a recently identified topological surface excitation in magnetized plasmas. We show that TLCW originates from the topological phase transition at the Langmuir wave-cyclotron wave resonance. By isofrequency surface analysis and two- and three-dimensional time-dependent simulations, we demonstrate that the TLCW can propagate robustly along complex phase transition interfaces in a unidirectional manner and without scattering. Because of these desirable features, the TLCW could be explored as an effective mechanism to drive current and flow in magnetized plasmas. The analysis also establishes a close connection between the newly instituted topological phase classification of plasmas and the classical Clemmow-Mullaly-Allis (CMA) diagram of plasma waves.
We report a generation of energetic protons by the interaction of a high-energy electron driving beam with an underdense plasma slab. After an interaction period of approximately 4000 fs, a proton beam with maximum energy greater than 250 MeV can be achieved by applying a driving beam with energy 1.0 GeV to a 200 $\mathrm {\mu }$m plasma slab. Our two-dimensional particle-in-cell simulations also show that the proton acceleration process can be divided into two stages. In the first stage, a strong positive longitudinal electric field appears near the rear boundary of the plasma slab after the driving beam has passed through it. This acceleration process is similar to the target normal sheath acceleration scheme by the interaction between intense pulsed laser with overdense plasma targets. In the second stage, the accelerated protons experience a long-range acceleration process with a two-stream instability between the high-energy driving beam and the proton beam. Further analyses show that this accelerated proton beam is equipped with the property of good collimation and high energy. This scheme presents a new way for proton or ion acceleration on some special occasions.
Dynamics of two-dimensional flow past a rigid flat plate with a trailing closed flexible filament acting as a deformable afterbody are investigated numerically by an immersed boundary-lattice Boltzmann method for the fluid flow and a finite element method for the filament motion. The effects of Reynolds number ($Re$) and length ratio ($Lr$) on the flow patterns and dynamics of the rigid-flexible coupling system are studied. Based on our numerical results, five typical state modes have been identified in $Lr\unicode{x2013}Re$ plane in terms of the filament shape and corresponding dynamics, i.e. static deformation, micro-vibration, multi-frequency flapping, periodic flapping and chaotic flapping modes, respectively. Benefiting from the passive flow control by using the flexible filament as a deformable afterbody, the coupled system may enjoy a significant drag reduction (up to $22\,\%$) compared with bare plate scenarios ($Lr=1$). Maximum drag reduction achieved at $L_{c,{min}} \in [1.8, 2]$ is often accompanied by the onset of the system state transition. The flow characteristic and its relation to the change in hydrodynamic drag are further explored in order to reveal the underlying mechanisms of the counterintuitive dynamical behaviour of the coupled system. The scaling laws for the form drag and the friction drag, which arise from the pressure and viscous effects, respectively, are proposed to estimate the overall drag acting on the system. The results obtained in the present study may shed some light on understanding the dynamical behaviour of rigid-flexible coupling systems.
Linus Pauling in 1950 published a three-dimensional model for a universal protein secondary structure motif which he initially called the alpha-spiral. Jack Dunitz, then a postdoc in Pauling's lab suggested to Pauling that the term helix is more accurate than spiral when describing the right-handed peptide and protein coiled structures. Pauling agreed, hence the rise of the alpha-helix, and, by extension, the ‘double helix’ structure of DNA. Although structural biologists and protein chemists are familiar with varying polar and apolar characters of amino acids in alpha-helices, to non-experts the three chemically distinct alpha-helix types classified here may hide in plain sight.
The essence of sub-critical transition of oscillatory boundary-layer flows is the non-modal growth of finite-amplitude disturbances. The current understanding of the mechanisms of the orderly and bypass transitions of oscillatory boundary-layer flows is limited. The present study adopts optimisation approaches to predict the maximum energy amplification of two- and three-dimensional perturbations in response to the optimal initial disturbance with or without external forcing. A series of direct numerical simulations are also performed to compare with the results obtained from the stability analyses. In particular, the optimal initial perturbation similar to a Tollmien–Schlichting (T–S) wave yields the largest transient growth under the combined effects of the Orr mechanism and inflectional point instability. With a considerable level of two-dimensional disturbance, the vortex tube nonlinearly develops from the T–S-like wave, and then either deforms into a $\varLambda$-vortex in the near-wall region or rolls up to the free shear region. The further burst of turbulence can follow the first pathway as K-type transition or the second one as vortex tube breakdown due to the elliptical instability. Additionally, non-modal growth can initiate the inception of streaky structures by favourable three-dimensional initial perturbations and/or forcing. The secondary instabilities responsible for the streak breakdown are classified as the varicose (symmetric) and sinuous (anti-symmetric) modes. Under a sufficiently high level of three-dimensional disturbance, the bypass transition is predominantly characterised by the formation of the sinuous mode and turbulent spots, which leads to the suppression of inflection point instability.
Membrane transporters including glucose transporters (GLUTs) are involved in cellular energy supplies, cell metabolism and other vital biological activities. They have also been implicated in cancer proliferation and metastasis, thus they represent an important target in combatting cancer. However, membrane transporters are very difficult to study due to their multispan transmembrane properties. The new computational tool, AlphaFold2, offers highly accurate predictions of three-dimensional protein structures. The glutamine, threonine and tyrosine (QTY) code provides a systematic method of rendering hydrophobic sequences into hydrophilic ones. Here, we present computational studies of native integral membrane GLUTs with 12 transmembrane helical segments determined by X-ray crystallography and CryoEM, comparing the AlphaFold2-predicted native structure to their water-soluble QTY variants predicted by AlphaFold2. In the native structures of the transmembrane helices, there are hydrophobic amino acids leucine (L), isoleucine (I), valine (V) and phenylalanine (F). Applying the QTY code, these hydrophobic amino acids are systematically replaced by hydrophilic amino acids, glutamine (Q), threonine (T) and tyrosine (Y) rendering them water-soluble. We present the superposed structures of native GLUTs and their water-soluble QTY variants. The superposed structures show remarkable similar residue mean square distance values between 0.47 and 3.6 Å (most about 1–2 Å) despite >44% transmembrane amino acid differences. We also show the differences of hydrophobicity patches between the native membrane transporters and their QTY variants. We explain the rationale why the membrane protein QTY variants become water-soluble. Our study provides insight into the differences between the hydrophobic helices and hydrophilic helices, and offers confirmation of the QTY method for studying multispan transmembrane proteins and other aggregated proteins through their water-soluble variants.
In this paper, effects of discharge parameters and modulation frequency on the signal of laser-induced fluorescence measurements of ion velocity distribution functions are investigated in the LIF Test Source. A maximum modulation frequency is found for each given set of parameters, beyond which the signal gradually declines. Meanwhile, this maximum modulation frequency occurred consistently at ~1/10 of the theoretical frequency limit and photon counts received by a photomultiplier tube, which indicates that as modulation frequency and the associated per-pulse-excitation-event count decrease, the transition from the macroscopic statistical signal to the microscopic probabilistic signal is a gradual process.
We report on the generation and delivery of 10.2 PW peak power laser pulses, using the High Power Laser System at the Extreme Laser Infrastructure – Nuclear Physics facility. In this work we demonstrate for the first time, to the best of our knowledge, the compression and propagation of full energy, full aperture, laser pulses that reach a power level of more than 10 PW.
An optimized compact stellarator with four simple coils is obtained from direct optimization via a coil shape. The new stellarator consists of two interlocking coils and two vertical field coils similar to those of the Columbia Non-neutral Torus (CNT) (Pedersen et al., Phys. Rev. Lett., vol. 88, 2002, pp. 205002). The optimized configuration has a global magnetic well and a low helical ripple level comparable to that of Wendelstein 7-X (W7-X) (Wolf et al., Nucl. Fusion, vol. 57, 2017, pp. 102020). The two interlocking coils have a smooth three-dimensional shape much simpler than those of advanced stellarators such as W7-X. This result opens up possibilities of future stellarator reactors with simplified coils.
We report a laboratory study on the scattering, energy dissipation and mean flow induced by internal gravity waves incident upon slopes with varying surface roughness. The experiment was performed in a rectangular box filled with thermally stratified water. The roughness of the slope surface, $\lambda$, defined as the height of a roughness element over its base width, and the off-criticality $\gamma =(\alpha -\beta )/\beta$, with $\alpha$ and $\beta$ being the angles of the incident wave and the slope, are used as two control parameters. The distribution of energy dissipation in the direction normal to the slope is found to be more uniform in the rough surface cases. Counter-intuitively, both the maximum value in the dissipation profile and the total energy dissipation near the slope are reduced by surface roughness under most circumstances. The measured peak width (the full width at half-maximum of the peaks) of the dissipation profile is found to be broadened significantly in the rough surface cases. We also observed that there exists a non-zero optimal off-criticality ($\gamma =0.17$ for the present measurement resolution) for the normalized average dissipation and total dissipation, which may be due to the strongest wave energy near the slope at this $\gamma$. Unlike surface roughness, the off-criticality has a small effect on the distribution of energy dissipation. Moreover, surface roughness is also found to change the structure of the scattering-induced mean flow and enhance its strength. The present study provides new perspectives on how the surface roughness on topographic features influences energy dissipation.