Dendroclimatology in the Eastern Mediterranean (EM) region has made important contributions to the understanding of climate variability on timescales of decades to centuries. These contributions, beginning in the mid-20th century, have value for resource management, archaeology, and climatology. A gradually expanding tree-ring network developed by the first author over the past 15 years has been the framework for some of the most important recent advances in EM dendroclimatology. The network, now consisting of 79 sites, has been widely applied in large-scale climatic reconstruction and in helping to identify drivers of climatic variation on regional to global spatial scales. This article reviews EM dendroclimatology and highlights contributions on the national and international scale.