Integrated weed management practices that reduce selection for resistance on herbicides are critical to delay resistance. To quantify the reduction in selection for resistance placed on Palmer amaranth from 2,4-D applied postemergence in cotton, an experiment was conducted three times in Georgia during 2020 and 2021 evaluating the benefits of (i) a cover crop, (ii) preemergence herbicides, and (iii) timeliness of applications. When a timely total-postemergence program of glyphosate + 2,4-D was applied three times over the season in a conventionally tilled system, 281,690 glyphosate-resistant Palmer amaranth plants ha–1 were exposed to 2,4-D. Over 61,500 of these plants were exposed to multiple 2,4-D applications. Altering the production system to conservation tillage, and including a rolled-rye cover crop, reduced the total number of plants exposed to 2,4-D for the season by 72% and the number of plants exposed multiple times by 60%. Even more effective, including a mixture of residual preemergence herbicides reduced the number of plants exposed to 2,4-D at least once over 99.9%, and reduced multiple exposures over 99.3% for the season; this benefit was observed for both conventional and conservation tillage systems. Delaying the initial application of the total-postemergence program did not influence the number of Palmer amaranth plants treated at least once but increased the number of plants treated multiple times by a factor of 3.7 times. As a result of early-season weed competition, cotton height and yield reductions were also associated with both lack of preemergence residuals and delayed postemergence applications. When considering the goal of minimizing the number of Palmer amaranth treated with a postemergence application of 2,4-D in a cotton system, the preemergence was the most effective option followed by (fb) the cover crop fb making timely postemergence applications. However, the most effective approach was to utilize each of these tactics in the same growing season.