Flumioxazin is used in nursery production and landscape maintenance industries. In these situations, weed control provided by flumioxazin often lasts longer than that reported in soil. Our objective was to quantify flumioxazin longevity under conditions found in nursery production. Pots were filled with 6 : 1 (v/v) pine bark : sand mixture. This nonsoil media is typical of what is used for nursery crop production. Pots were treated with flumioxazin at either 0.28 or 0.42 kg ai ha−1, and subsequently sown with either hairy bittercress (two winter experiments) or spotted spurge (two summer experiments) at weekly intervals. Weed seed germination, emergence, and seedling establishment in the treated pots was compared with nontreated control and used as a proxy for herbicide activity. Flumioxazin provided approximately 7 wk of complete (100%) hairy bittercress control regardless of rate. However, a rate effect was evident in only one of the two experiments conducted with hairy bittercress. In both experiments with hairy bittercress, marginal and highly variable activity was still evident at 18 wk after treatment. Flumioxazin at 0.28 and 0.42 kg ha−1 provided 2- and 4-wk complete spotted spurge control, respectively. No spotted spurge control was evident after about 8 wk. Subjecting this less-variable data to nonlinear regression revealed that the time required for 50% reduction in flumioxazin activity was approximately 5.5 and 6.6 wk for the two rates, respectively. A column leaching study revealed that flumioxazin activity remained localized near the surface (0 to 4 cm). Therefore the dissipation observed was likely the result of in situ degradation and not displacement. The high organic matter content of the nonsoil media contributes to the observed persistence of flumioxazin activity.