Introduction. Physalis has been known for a long time in Egypt. Amongunexploited tropical fruits, Physalis is a very promising fruit. Recently, the economicimportance of Physalis has risen, due to its high acceptance for local consumption,achieving great success in the African, Latin American and European markets. One of thechallenges of recent years has been to participate in the development of Physalis as acommercial crop of economic utility. In order to understand the nutraceutical andmedicinal characteristics of Physalis fruits cultivated in Egypt, the biochemicalcomposition of the raw Physalis pubescens juice was determined.Materials and methods. Whole fresh fruits of Physalis pubescensfrom Egypt were preserved at –20 °C for the duration of the experiment. Thejuice was extracted from Physalis fruits by using a fruit pulper then filtered oncheesecloth to separate seeds and skins. Contents of oil, fatty acids, proteins, aminoacids, sugars and minerals of the juice were analyzed, and were compared and discussed inrelation to the biochemical composition of other fruits and vegetable oils.Results. Yield of the juice was high (64%) and it is a rich source ofminerals such as potassium (11.32 g·100 g–1 dm), phosphorus(5.55 g·100 g–1 dm), zinc (0.02 g·100 g–1 dm) and boron(0.01 g·100 g–1 dm), polyphenols (76.6 mg·100 mL–1) andcarotenoids (70 µg·mL–1). It contained good amounts of vitamin C(38.77 mg·100 mL–1) and it could be a good potential source of essentialamino acids such as isoleucine, valine and tryptophan [(4.2, 3.9 and3.9) g·100 g–1 protein], whose amounts were higher than those recommended bythe FAO / WHO / UNU. Additionally, it contains a low amount of oil(1.1 g·100 g–1 dm). Conclusion. Physalis juice should attractgreat interest because of its composition. Its potential nutraceutical quality couldparticipate in the development of Physalis as a commercial crop. Certain molecules such asantimicrobial molecules and bioactive withanolides, which have the famous ethnomedical andmedical effects of Physalis juice, still have to be studied.