Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

1 results

  • 3 - Melatonin, Light, and the Circadian System

  • Edited by Laura K. Fonken, University of Texas, Austin, Randy J. Nelson, West Virginia University
  • Book:
    Biological Implications of Circadian Disruption
    Published online:
    07 October 2023
    Print publication:
    12 October 2023, pp 58-83

  • Summary

    This review summarizes evidence on the modulation of functional responses mediated by activation of the MT1 and/or MT2 melatonin receptors by endogenous or exogenous melatonin. Selective MT1 inverse agonists, discovered by docking ultra large compound libraries to the MT1 crystal structure, decelerated the rate of re-entrainment of activity rhythms to a new dark onset. Surprisingly, these inverse agonists advanced circadian phase when given at subjective dusk mimicking melatonin through actions at MT1 receptors. The efficacy of environmental carbamates with structural similarity to melatonin interact with melatonin receptors and in turn advance circadian clock phase, as with melatonin. In summary, melatonin receptors are targets for drugs modulating circadian rhythms to yield therapeutic effects (i.e., synchronization), as well as for environmental chemicals that may induce harmful effects on human health due to actions on melatonin and on/off target receptors (e.g., serotonin) involved in signaling circadian time at inappropriate times of day.