Johnsongrass control systems that included commercially available corn herbicides applied to crop sequences of continuous corn or corn–cotton–corn rotation were evaluated over a 3-yr period at the Texas Agricultural Experiment Station in Burleson County. Herbicide treatments evaluated were EPTC + R-25788 applied preplant incorporated (PPI); metolachlor applied preemergence (PRE); nicosulfuron applied postemergence (POST); and the combination of metolachlor PRE and glyphosate POST applied after corn harvest. Weed control practices applied to plots planted to cotton in the second growing season provided excellent johnsongrass control (≈ 95%). Visual control ratings indicated that nicosulfuron provided the best johnsongrass control (> 80%) among the herbicides evaluated all three years. Metolachlor and glyphosate combinations provided acceptable johnsongrass control the third year of the experiment in both cropping sequences. Corn grain yield and johnsongrass control were best in cotton-rotated plots. The highest returns observed in continuous corn were from either nicosulfuron or the combination of metolachlor and glyphosate. Net returns for all control systems in corn–cotton–corn rotated plots were greater than the weedy check and were equivalent to the lead systems in continuous corn.