The aim of our paper is to study some aspects of the textile industry of the city of Segovia and its land in the second half of the 16th century, interpreting them through spatial economy theories and specifically the industrial district approach. It is about seeing the competitive advantages of the integration and diffusion of the business organization in its geographical framework. The district's competitive advantages are linked to both transaction and production costs. One of them is to maximize the benefits of labor market segmentation with the emergence of a primary market for skilled labor. Another is the ease of diffusion of both technology and organizational and commercial techniques.