Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

1 results

  • The effect of OK-432 (Picibanil) injection on the histopathology of nasal turbinate

  • S Sengul, İ Kaygusuz, M M Akin, Ş Yalcin, T Karlidag, E Keles, İ Arslan
  • Journal:
    The Journal of Laryngology & Otology / Volume 129 / Issue 12 / December 2015
    Published online by Cambridge University Press:
    12 October 2015, pp. 1208-1212
    Print publication:
    December 2015
  • Objective:

    This study aimed to assess the histopathological effect of OK-432 (Picibanil) on rabbit nasal turbinates.

    Methods:

    A total of 21 rabbits were divided into 3 treatment groups and various parts of both nasal turbinates were injected with 0.5 ml OK-432, 0.2 ml OK-432 or 0.6 ml saline (control). Bilateral nasal turbinates were later excised and studied under light microscopy to assess any histopathological changes.

    Results:

    Animals in the 0.2 ml and 0.5 ml OK-432 groups exhibited mild ciliary loss, goblet cell loss and epithelial damage, and a marked increase in inflammatory cell infiltration, submucosal vascularisation and fibrosis. There was a significant difference in histopathological changes between the two OK-432 treated groups. In addition, each OK-432 treated group had significantly more inflammatory cell infiltration, increased submucosal vascularisation and fibrosis compared with controls.

    Conclusion:

    The marked fibrosis observed in OK-432-injected turbinates may be responsible for a reduction in turbinate size.