Persons with multiple sclerosis (MS) often report prospective memory (PM) failures that directly impact their everyday life. However, it is not known whether PM deficits confer an increased risk of poorer everyday functioning. The aims of this study were to: (1) compare time- (Time-PM) and event-based PM (Event-PM) performance between persons with MS and healthy controls (HCs), (2) examine the neuropsychological correlates of PM in MS, and (3) examine the relationship between PM and everyday functioning in MS.

A between-subjects design was used to examine 30 adults with MS and 30 community-dwelling HC. Participants were administered the Memory for Intentions Screening Test (MIST) to assess PM skills, the Actual Reality™ (AR) to assess everyday functioning, and a battery of cognitive tests.

The MS group performed significantly worse on Time-PM compared to HC but not on Event-PM tasks. While both Time-PM and Event-PM subscales were correlated with retrospective learning and memory, the MIST Time-PM subscale was correlated with executive functions. Significant correlations were observed between AR and the MIST Time-PM, but not Event-PM, subscales.

The results highlight the role of executive functions on Time-PM. Furthermore, significant relationships with AR extend the ecological validity of the MIST to MS populations.