Field studies were conducted at five locations in North Carolina and Virginia in 1996 and 1997 to evaluate weed control and peanut (Arachis hypogaea) response to diclosulam that was applied preemergence (PRE) and in systems with commercial standards. All plots received a preplant incorporated (PPI) treatment of ethalfluralin at 840 g ai/ha. Diclosulam controlled common lambsquarters (Chenopodium album L.), eclipta (Eclipta prostrata L.), entireleaf morningglory (Ipomoea hederacea var. integriuscula Gray), ivyleaf morningglory [Ipomoea hederacea (L.) Jacq.], pitted morningglory (Ipomoea lacunosa L.), and prickly sida (Sida spinosa L.) as well as and frequently better than the commercial standards of acifluorfen plus bentazon applied postemergence (POST), paraquat plus bentazon early POST followed by (fb) imazapic POST, or imazapic POST. Systems with ethalfluralin PPI plus diclosulam PRE at 26 g ai/ha fb acifluorfen plus bentazon POST controlled a broader spectrum of weeds and yielded greater than systems of ethalfluralin PPI fb imazapic POST or ethalfluralin PPI fb acifluorfen plus bentazon POST. Peanut exhibited excellent tolerance to diclosulam PRE at 17, 26, or 35 g/ha.