Newspapers expanded around 1900 to reach a wider readership, often reporting sensationalized stories about science. Attacks on the Darwinian theory of natural selection intensified, leading to claims that the theory was on its deathbed. Lamarckism remained active along with the theory of directed variation (orthogenesis), both presented as less materialistic than Darwinism. New alternatives appeared, including the ‘mutation theory’ (evolution by jumps) and genetics, which was at first presented as a threat to Darwinism rather than a supporting factor. In the 1920s a new surge of creationism in the United States intensified the attack on Darwinian materialism, culminating in the widely reported trial of J. T. Scopes. The same critiques appeared in a less muted form in Britain. The Darwinian ‘struggle for existence’ remained a source of anxiety for those who feared a potential threat to moral values and social stability.

In the 1920s and 1930s the Darwinian selection theory was linked to genetics, providing it with a secure foundation, although wider dissemination of this initiative was limited until the 1940s. Historians note that the ‘evolutionary synthesis’ was a rhetorical device to create an impression of unity, leaving the various disciplines involved still functioning independently. Radio now became an important means of disseminating science news, as in the 1959 celebrations of the centenary of the Origin of Species. The new version of Darwinism eroded the plausibility of eugenics and race theory, although these ideologies remained active in less visible forms. Popular accounts of evolutionism now stressed its open-endedness and played down the old assumption that humanity must be the inevitable outcome of progress. Julian Huxley tried to give the synthesis a moral dimension by linking it to his philosophy of humanism, but creationists saw the new initiative in science as a continuation of Darwinian materialism and renewed their attacks.

Suppose you are running a company that provides proofreading services to publishers. You employ people who sit in front of screens, correcting written text. Spelling errors are the most frequent problem, so you are motivated to hire proofreaders who are excellent spellers. Therefore, you decide to give your job applicants a spelling test. It isn’t hard: throw together 25 words, and score everyone on a scale of 0–25. You are now a social scientist, a specialist called a psychometrician, measuring “spelling ability.”

The reader should be officially informed that in this chapter I take leave of the widely accepted consensus about nature–nurture. This is not a textbook, and everything that I have said up to now has been very much my own take on things, but for the most part I have not strayed far from what most scientists would say about the intellectual history of nature and nurture. Not everyone perhaps, but most people agree that Galton was a racist, eugenics a moral and scientific failure, heritability of behavioral differences nearly universal, heritability a less than useful explanatory concept, twin studies an interesting but ultimately limited research paradigm, and linkage and candidate gene analysis of human behavior decisive failures.

Has it always been the case that living people must struggle with the moral failings of their dead ancestors, or is that a special burden that has been placed on the shoulders of citizens and scientists living in contemporary Europe and North America? Recently, the culture feels as though it is being torn apart by this question. I was taught in grade school that the United States is the greatest country in the world, the land of the free and the home of the brave, where anyone could be a millionaire or president if they put in the effort. It is hardly radical to recognize that this is less than true today and isn’t even close to true historically, especially if one is not white, Christian, and male.

Notwithstanding Galton’s admonition to count everything, counting is just a tool; it is no more science than hammering is architecture. One hundred years after Galton, Robert Hutchins remarked, contemptuously, that a social scientist is a person who counts telephone poles. The obvious way to turn counting into science is by conducting experiments, that is by manipulating nature and observing what the consequences are for whatever one is counting. Gregor Mendel, for example, was certainly a counter – he counted the mixtures of smooth and wrinkled peas in the progeny of the pea plants he intentionally crossed. What made Mendel’s work science was the intentional crossing of the plants, not the counting itself. It would have been much more difficult – perhaps impossible – to observe the segregation and independent assortment of traits by counting smooth and wrinkled peas in the wild.

Why is divorce heritable? It’s clear that it is heritable, in the rMZ > rDZ sense. I hope I have convinced you that the heritability of divorce doesn’t mean that there are “divorce genes,” or that divorce is passed down genetically from parents to children, but seriously: how does something like that happen? I am aware that my constant minimizing of the implications of heritability can seem as though I am keeping my finger in the dike against an inevitable onslaught of scientifically based genetic determinism, the final Plominesque realization that our genes make us who we are, the apotheosis of Galton’s proclamation in 1869: “I propose to show … that a man’s natural abilities are derived by inheritance, under exactly the same limitations as are the form and physical features of the whole organic world” (Hereditary Genius, p. 1).

Robert Plomin, whose name has come up a few times already, is unquestionably the most important psychological geneticist of our time. Trained in social and personality psychology at the University of Texas at Austin in the 1970s (my graduate alma mater, though we didn’t overlap), he went on to faculty positions at the University of Colorado and the Pennsylvania State University (both major American centers for behavior genetics) before moving to London to take a position at the Institute of Psychiatry. Plomin’s career has embodied the integration of behavioral genetics into mainstream social science and psychology. Everywhere Plomin has been, he has initiated twin and adoption studies, many of which continue to make contributions today. Although genetics has always played a central role in Plomin’s research, you would never mistake his work for that of a biologist or quantitative geneticist: he (like me) has always been first and foremost a psychologist.

The Second World War marked a turning point for what was considered acceptable in genetics and its implications for eugenic and racially motivated social policies. To be sure, the change in attitude was not quick or decisive. Tens of thousands of Americans were sterilized involuntarily after the war. Anti-black racism, antisemitism, and anti-immigrant sentiment, needless to say, persisted for a long while and have not yet been eliminated; interracial marriage was still illegal in much of the country during my lifetime. But – and despite the foot-dragging, I think this needs to be recognized as an advance – it slowly became less and less acceptable to adopt openly eugenic or racist opinions in public or to justify them based on science. Retrograde attitudes about such things persist to this day, but they have mostly been relegated to the fringes of scientific discourse.

Many people outside of psychology and biology come to the subject of nature–nurture because of an interest in race. That is unfortunate, but I get it. People, especially in the United States, are obsessed with race, for obvious reasons: American history is indelibly steeped in racial categories. The two foundational failures of the American experience – genocide of Indigenous Americans and enslavement of Africans – happened because of race and racism. Even today in the United States, people of all persuasions think about race all the time, whether as hereditarian racists convinced that there are essential biological differences among ancestral groups, progressives fascinated by personal identity and the degradations that non-white people still experience, or the dozens of racial and ethnic categories obsessively collected by the U.S. census.

This chapter presents how scientists currently use the increasing number of individuals who live to an age above 90 years (i.e. long-lived individuals) to investigate biological determinants of longevity. It will provide an overview of the most extensive studies of exceptionally long-lived individuals and long-living families that have been established since the early 1970s. The focus of the chapter will be on the metabolic phenotypes and the genetic determinants that characterize them. It will discuss the delayed occurrence of age-related disease in long-lived individuals and their offspring as well as their favourable immune-metabolic profile, that is, improved glycaemic control, lipid and thyroid metabolism and immunity. Moreover, it will provide an overview of studies focused on unravelling the genetic component of longevity, which is assumed to be partly responsible for the observed immune-metabolic profile. The findings from these studies indicate that longevity is most likely determined by many different rare protective genetic variants that still need to be identified, for example using whole genome/exome sequencing approaches. Last, but not least, the chapter will discuss some of the implications of the presented findings for medical research on ageing and age-related diseases.

Let’s summarize where the nature–nurture debate stood as the twentieth century drew to a close. When the century began, thinkers were faced for the first time with the hard evolutionary fact that human beings were not fundamentally different biologically than other evolved organisms. Galton and his eugenic followers concluded that even those parts of human experience that seemed to be unique – social, class, and cultural differences; abilities, attitudes, and personal struggles – were likewise subsumed by evolution and the mammalian biology it produced. People and societies could therefore be treated like herds of animals, rated on their superior and inferior qualities, bred to maintain them, treated to fix them, and culled as necessary for the good of the herd. Not every mid-century moral disaster that followed resulted from their misinterpretation of human evolution, but it played a role. Society has been trying to recover from biologically justified racism, eugenics, and genocide ever since.

The theory of evolution, as espoused by Charles Darwin in The Origin of Species in 1859, was difficult to accept for religious believers whose assumptions about the world were shattered by it, but Darwin’s The Descent of Man, published 12 years later, posed even greater challenges to people who did accept it, and those challenges continue today. It has often been noted that a disorienting consequence of the Enlightenment was to force people to recognize that humans were not created at the center of the universe in the image of God, but instead on a remote dust-speck of a planet, in the image of mold, rats, dogs, and chimps. For the entirety of recorded history, moral beliefs about humans had been based on the idea that people were in some fundamental sense apart from the rest of nature. Darwin disabused us of that notion once and for all. The scientific and social upheaval that has occurred since Darwin has been an extended process of coming to terms with a unification of humans and the rest of the natural world.

This chapter explores two different systems of research oversight in recent Brazilian history: the bureaucracies of the twentieth and twenty-first-century Brazilian state, and approaches developed by A’uwẽ (Xavante) aldeias over the same period in Pimentel Barbosa Indigenous Land. Focusing primarily on genetics-based research, Dent develops the concept of bureaucratic vulnerability. She argues that the way some geneticists have interpreted state regulatory systems regarding biosamples creates additional risks for Indigenous people under study. At the same time, Indigenous groups are placed in a bureaucratic double bind, where non-Indigenous experts are called on to justify and validate their claims in the eyes of the state. The protectionist state regulation contrasts with relationship-based practices that A’uwẽ interlocutors have developed over repeated interaction and years of collaboration with a group of anthropologists and public health researchers. Specifically, A’uwẽ have responded to the dual and interrelated challenges of recognition under a colonial state and the management of outside researchers through the careful modulation of researchers’ affective experience of fieldwork, working to create enduring relationships and mutual obligation.