Field experiments were conducted to determine factors that predispose winter wheat to injury by sulfonylurea herbicides. Wheat was injured occasionally when herbicides were applied postemergence in November or when tank mixed with malathion. CGA 131036 at 28 or 56 g ha-1 was less injurious than chlorsulfuron or DPX-G8311 at 26 or 53 g ha-1, and preemergence treatments of chlorsulfuron and DPX-G8311 were less injurious than preplant incorporated or postemergence treatments. Wheat growth stage, minimum post-treatment daily temperature, and summed diurnal temperature fluctuations after treatment and after first post-treatment rainfall were correlated with wheat injury. Grazing and cultivar selection did not affect injury.