Red Bird was a Cherokee murdered at the Red Bird River Petroglyph site (15Cy51) and buried at the Red Bird River Rockshelter (15Cy52) during the late eighteenth century, where he left an important record of traditional petroglyphs. His legacy is key to understanding the origins of Sequoyah's Cherokee Syllabary and its relationship to rock art. Personal testimonies of Red Bird's descendants are supported by primary documents and archaeological evidence, including the letters of Sequoyah's maternal uncle, John Watts, and prototypes of Cherokee Syllabary characters engraved at 15Cy52 in 1808, when members of Sequoyah's matrilineal family resided nearby.

Inside Manitou Cave in modern Alabama, nineteenth-century Cherokees carried out sacred ceremonies, recording their activities on the walls using Cherokee syllabary, a system invented in nearby Willstown by Cherokee scholar Sequoyah. Through collaboration between modern Cherokee scholars and Euro-American archaeologists, the authors report and interpret—for the first time—the inscriptions in Manitou Cave. These reveal evidence for secluded ceremonial activities at a time of crisis for the Cherokee. Pressures from the surrounding white populations disrupted the Cherokee ancient lifeways, culminating in their forcible relocation in the 1830s along the Trail of Tears.

The authors investigate the origins of the earliest script of the Cherokees, using inscriptions in the Red Bird River Shelter. Their analysis suggests that the engravings in the cave show the experimental creation of a syllabary (alphabet of signs). This in turn offers support for the historical notion that this writing system was not an ancestral practice preserved through missionaries, but an invention of the early nineteenth century; one that should be credited to the Native American pioneer scholar, Sequoyah.

Objective: This study compared medical history and findings on initial clinical examination in Native Americans diagnosed with possible or probable Alzheimer's disease (AD) at Native American satellite clinics of the University of Texas (UT) Southwestern Medical Center's Alzheimer's Disease Center with those of Whites diagnosed with probable AD at the UT Southwestern Medical Center's Alzheimer's Disease Clinic. Methods: The information reviewed was contained in the database of the UT Southwestern Alzheimer's Disease Center. Results: In relation to Whites, Native Americans had slightly but significantly greater age at onset of symptoms (71.7 vs. 69.6 years, t = −2.08, p = .04) and equivalent cognitive scores at evaluation (Mini-Mental State Exam score = 17.4 vs. 18.5, t = 0.98, p = .33), despite significantly lower educational level (11.4 vs. 13.4 years, t = 5.63, p < .001). Native Americans were more frequently depressed on examination (22.8% vs. 9.5%, χ2 = 12, p = .001) and reported diabetes, hypertension, and heart disease significantly more often than did Whites (p < .01 for all), but their survival time after AD diagnosis was similar to that of Whites despite these comorbidities. Conclusions: With the exception of a greater prevalence of depression and cardiovascular risk factors in Native Americans than in Whites, Native Americans had a course of illness similar to that of Whites.