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1 results

  • Evaluation of the VP22 gene adjuvant for enhancement of DNA vaccine against somatostatin in mice

  • Li. Han, A. X. Liang, J. Zhang, M. Fang, G. H. Hua, L. Sang, L. Y. Geng, H. R. Wang, L. G. Yang
  • Journal:
    animal / Volume 2 / Issue 11 / November 2008
    Published online by Cambridge University Press:
    01 November 2008, pp. 1569-1574
    Print publication:
    November 2008

  • Somatostatin (SS) is a hormone that inhibits the secretion of growth hormone. Immunization against SS can promote the growth of animals. A novel SS-VP22 fused vaccine, pEGS2SS-V, was constructed from pEGS2SS plasmid with a VP22 gene fragment. Two times of immunization with pEGS2SS-V-induced anti-SS antibodies in mice. Compared with mice immunized with pEGS2SS and 0.85% saline, the growth performance of mice immunized with pEGS2SS-V was increased by 14.1% (P < 0.05) and 48.4% (P < 0.01) on the 2nd week after the first vaccination, respectively. The results indicated that the effects of the somatostatin DNA vaccine could be improved effectively by VP22 gene adjuvant.