Field and greenhouse experiments were conducted to evaluate postemergence (POST) soybean injury and weed control with CGA-277476 and cloransulam-methyl alone and in tank mixtures. In the field, visible soybean injury was 12 to 14% from CGA-277476 and 9 to 13% from cloransulam-methyl 7 d after treatment. Tank mixtures of either herbicide with acifluorfen or acifluorfen plus thifensulfuron were more injurious than CGA-277476 or cloransulam-methyl applied alone. Both CGA-277476 and cloransulam-methyl reduced velvetleaf dry weight 82%, and cloransulam-methyl reduced common ragweed dry weight 92%. Neither herbicide adequately controlled common lambsquarters, redroot pigweed, nor eastern black nightshade. The addition of acifluorfen to the spray solution improved common ragweed, common lambsquarters, redroot pigweed, and eastern black nightshade control with CGA-277476 and improved common lambsquarters, redroot pigweed, and eastern black nightshade control with cloransulam-methyl. Tank mixing thifensulfuron with CGA-277476 or cloransulam-methyl increased common lambsquarters and redroot pigweed control. In the greenhouse, CGA-277476 at 20 g ai/ha reduced velvetleaf dry weight 98%, and 79 g/ha was required to reduce common ragweed dry weight 93%. Cloransulam-methyl at 4.4 g ai/ha reduced velvetleaf dry weight 98% and common ragweed dry weight 94% at 8.8 g/ha. Chlorimuron reduced yellow nutsedge dry weight more than CGA-277476 or cloransulam-methyl. Antagonism of POST graminicide activity by CGA-277476 was grass species and graminicide related. CGA-277476 reduced giant foxtail control by clethodim but not by quizalofop. Cloransulam-methyl tank mixed with clethodim or quizalofop controlled giant foxtail.