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Volume 14 - June 2015

Contents

Page 4 of 4

Short Communication

  • Five-year survival after palliative radiotherapy of T4/N3 lung cancer: case series and review of the literature

  • Federico Ampil, Srinivas Devarakonda, Carlos Previgliano, Glenn Mills
  • Published online by Cambridge University Press:
    22 August 2014, pp. 102-104

  • There is sparse literature regarding extended survival of patients treated for T4 and/or N3 lung cancers. We present the results of a case series from our radiotherapeutic experience over the last 12 years to provide additional information. Out of 189 individuals diagnosed with lung cancer between 1997 and 2008, seven treated patients who survived five years or longer were identified. The median age was 56 years. More than half of the subjects were symptomatic at the time of hospitalization, possessed voluminous, non-small-cell histologic type malignant neoplasms, and received chemotherapy also. All individuals responded to treatment, and their survival ranged from 60 to 169 months. Our observed long-term survivors seem to justify the continued practice of modern standards of care in patients with lung cancer.

  • Does intensity-modulated radiotherapy reduce the risk of pelvic insufficiency fractures in gynaecological cancers?

  • Vivek Nama, John Hughes, Alison Stapleton, Hoda Al-Booz
  • Published online by Cambridge University Press:
    14 January 2015, pp. 219-222
  • Background

    Increasingly we are using a combination of surgery, chemotherapy and radiotherapy for treatment of gynaecological malignancies. Most studies in literature are concentrated on the concept of survival. There is minimal data examining the impact of these treatments on quality of life. Survival being a surrogate marker is an arbitrary end point and is of arguable significance if quality of life is not maintained. Long-term side effects of radiotherapy are debilitating and severely affect quality of life. Pelvic insufficiency fractures (PIF) are a known long-term side effect of radiotherapy. Intensity-modulated radiotherapy (IMRT) is being routinely used in the treatment of prostate and head and neck cancer. We postulated that use of IMRT in gynaecological cancers reduces the incidence of PIF.

    Patients and methods

    We retrospectively reviewed 10 cases of PIF treated on standard treatment. We recalculated dose volume histograms based on IMRT protocols for patients with PIF.

    Results

    We found that none of the patients received any radiation at the fracture site and the total radiation received to the sacrum was lower compared with the standard treatment protocols.

    Conclusions

    We conclude that the feasibility of IMRT in gynaecological cancers should be further evaluated and might be an useful tool in reducing the number of PIF.

Book Review

Page 4 of 4