Infantile autism is a heterogenous disorder with unknown aetiology.
Evidence from the
relatively few family and twin studies suggests a genetic component. Co-occurrence
or
cosegregation between infantile autism and chromosomal abnormalities may
identify
candidate regions, which could be tested in linkage or association studies.
The purpose of this study was to use the Danish Cytogenetic Central
Register in order to
detect autosomal chromosome abnormalities associated with infantile autism,
and to review
the literature for cases of autism associated with autosomal chromosome
abnormalities to
identify candidate chromosomal regions.
The register-based study identified possible candidate regions on chromosome
7q21 and
10q21.2, which have not previously been reported.
A few interesting candidate regions, 15q11–13, 16q23, and 17p11.2
were found in the
literature survey.