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Volume 17 - May 2002

Contents

Page 6 of 56

Short Communications

  • 5-HT2A gene promoter polymorphism as a modifying rather than a vulnerability factor in anorexia nervosa

  • A. Kipman, L. Bruins-Slot, C. Boni, N. Hanoun, J. Adès, P. Blot, M. Hamon, M.-C. Mouren-Siméoni, P. Gorwood
  • Published online by Cambridge University Press:
    16 April 2020, pp. 227-229

  • The A allele of the 5-HT2A gene (–1438A/G polymorphism) has been associated with anorexia nervosa in four studies, but not in three others. One possibility to explain such a discrepancy is that the A allele acts as a modifying rather than a vulnerability allele. To test this hypothesis, we increased our initial sample of 102 trios [Mol. Psychiatry 7 (2002) 90] with 43 new patients with anorexia nervosa and 98 healthy controls. In addition to confirming the absence of association on the global sample of 145 patients, we found that patients with the A allele had a significantly later age at onset of the disease (P = 0.032). Furthermore, the A allele was also transmitted with an older age at onset (P = 0.023) using a quantitative-trait TDT approach. The A allele may thus act as a modifying factor (delaying onset), potentially explaining variations of allele frequency across samples, in which differences in average age at onset are not only possible, but also expected. Taking into account vulnerability genes, but also genes modifying the expression of the disorder, will help to disentangle the complexity of the etiological factors involved in anorexia nervosa.

Short communication

Case report

Back matter

  • EPA volume 17 issue S3 Cover and Back matter

  • Published online by Cambridge University Press:
    01 October 2020, p. b1
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Case report

SES02. AEP Section Psychopharmacology - Modern clinical psychopharmacology - focus on patient-treatment concordance

Symposia

  • Old versus new antipsychotic drugs in relation to treatment concordance

  • W. Wolfgang Fleischhacker
  • Published online by Cambridge University Press:
    16 April 2020, p. 2s
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Letter to the editor

  • Biological basis and staging of Cotard’s syndrome

  • H.S. Duggal, K. Jagadheesan, S. Haque Nizamie
  • Published online by Cambridge University Press:
    16 April 2020, pp. 108-109
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News

  • AEP News

  • Published online by Cambridge University Press:
    16 April 2020, pp. 369-370
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Letter to the editor

AEP News

  • Continuous Medical Education (CME) Educational Courses and Workshops at the 11th AEP Congress (Stockholm, 4–8 May2002)

  • Published online by Cambridge University Press:
    16 April 2020, pp. 111-114
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Letter to the Editor

  • Upper-extremity self-amputation in a case with schizophrenia

  • Toshiyuki Kobayashi, Takuro Osawa, Satoshi Kato
  • Published online by Cambridge University Press:
    16 April 2020, pp. 172-173
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Case Report

SES02. AEP Section Psychopharmacology - Modern clinical psychopharmacology - focus on patient-treatment concordance

Symposia

  • Compliance training programs

  • I.-M. Wieselgren
  • Published online by Cambridge University Press:
    16 April 2020, p. 2s
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Case report

Case Reports

AEP News

  • Stockholm, 4-8 May 2002 - 11th AEP Congress Program

  • Published online by Cambridge University Press:
    16 April 2020, pp. 57-59
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AEP CME Courses and Workshops

  • Liaison psychiatry: Identifying and treating psychiatric problems in a medical population

  • Francis Creed
  • Published online by Cambridge University Press:
    16 April 2020, p. 253s
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Front matter

  • EPA volume 17 issue 7 Cover and Front matter

  • Published online by Cambridge University Press:
    01 October 2020, pp. f1-f2
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Case Reports

  • Efficacy of lithium treatment in Kleine–Levin syndrome

  • F. Muratori, N. Bertini, G. Masi
  • Published online by Cambridge University Press:
    16 April 2020, pp. 232-233

  • The Kleine–Levin syndrome (KLS) is characterized by periodic, sudden-onset episodes of hypersomnia, compulsive hyperphagia, and behavioral–emotional symptoms, lasting from a few days to a few weeks, with complete remission in the intercritical periods. We report on efficacy of lithium treatment in a highly recurring form of the disorder in a 17-year-old male adolescent. The decreasing severity of the disorder paralleled the progressive increase of lithium dosage, up to 0.9 mEq l–1. Implications regarding the pharmacological treatment of this neglected disorder are discussed.

Front matter

  • EPA volume 17 issue 1 Cover and Front matter

  • Published online by Cambridge University Press:
    01 October 2020, pp. f1-f2
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Page 6 of 56