A. The effect of 6 annual systemic insecticide treatments on cattle grub infestation was ohserved in a range herd of beef cattle that are isolated during the fly oviposition period by at least 10 miles from areas where adjacent herds could have dropped pupae. The herd is ranged throughout the year on a large and rugged semi-mountainous area, and was increased during the study from 1200 to 1600 animals. Bulls were the only imports made into the herd. Beef and cull females were marketed in late autumn. Treatments were applied in early December during the annual weaning-culling gather of the herd. Treatments in 1957, 1958 and 1959 were with Trolene boluses and each animal was weighed before treatment. Treatments in 1960, 1961 and 1962 were with Ruelene pour-on and weights were estimated. Annually a randomly selected group of calves was left untreated, and grubs were removed from chis and a similar group of treated calves at intervals throughout the grub season. By comparison of the untreated and treated samples, the insecticides produced the following grub reductions: 1957 − 76.8%, 1958 − 89.0%, 1959 − 87.5%, 1960 − 91.7%, 1961 − 91.0% and 1962 − 100.0%. The average numbers of grubs per untreated calf were: 1957 − 30.2, 1958 − 14.5, 1959 − 1.6, 1960 − 2.5, 1961 − 2.7, and 1962 − 0.2. Prior to these treatments gadding had seriously disrupted summer management of the herd but it has not occurred since 1957. The quality of the herd has improved, but because of changes in management and bull quality, the precise effect of the treatments cannot be assessed. (G.B.R.)