Questions of ‘how best to acquire data’ are essential to modelling and prediction in the natural and social sciences, engineering applications, and beyond. Optimal experimental design (OED) formalizes these questions and creates computational methods to answer them. This article presents a systematic survey of modern OED, from its foundations in classical design theory to current research involving OED for complex models. We begin by reviewing criteria used to formulate an OED problem and thus to encode the goal of performing an experiment. We emphasize the flexibility of the Bayesian and decision-theoretic approach, which encompasses information-based criteria that are well-suited to nonlinear and non-Gaussian statistical models. We then discuss methods for estimating or bounding the values of these design criteria; this endeavour can be quite challenging due to strong nonlinearities, high parameter dimension, large per-sample costs, or settings where the model is implicit. A complementary set of computational issues involves optimization methods used to find a design; we discuss such methods in the discrete (combinatorial) setting of observation selection and in settings where an exact design can be continuously parametrized. Finally we present emerging methods for sequential OED that build non-myopic design policies, rather than explicit designs; these methods naturally adapt to the outcomes of past experiments in proposing new experiments, while seeking coordination among all experiments to be performed. Throughout, we highlight important open questions and challenges.

A convex cone is homogeneous if its automorphism group acts transitively on the interior of the cone. Cones that are homogeneous and self-dual are called symmetric. Conic optimization problems over symmetric cones have been extensively studied, particularly in the literature on interior-point algorithms, and as the foundation of modelling tools for convex optimization. In this paper we consider the less well-studied conic optimization problems over cones that are homogeneous but not necessarily self-dual.

We start with cones of positive semidefinite symmetric matrices with a given sparsity pattern. Homogeneous cones in this class are characterized by nested block-arrow sparsity patterns, a subset of the chordal sparsity patterns. Chordal sparsity guarantees that positive define matrices in the cone have zero-fill Cholesky factorizations. The stronger properties that make the cone homogeneous guarantee that the inverse Cholesky factors have the same zero-fill pattern. We describe transitive subsets of the cone automorphism groups, and important properties of the composition of log-det barriers with the automorphisms.

Next, we consider extensions to linear slices of the positive semidefinite cone, and review conditions that make such cones homogeneous. An important example is the matrix norm cone, the epigraph of a quadratic-over-linear matrix function. The properties of homogeneous sparse matrix cones are shown to extend to this more general class of homogeneous matrix cones.

We then give an overview of the algebraic theory of homogeneous cones due to Vinberg and Rothaus. A fundamental consequence of this theory is that every homogeneous cone admits a spectrahedral (linear matrix inequality) representation.

We conclude by discussing the role of homogeneous structure in primal–dual symmetric interior-point methods, contrasting this with the well-developed algorithms for symmetric cones that exploit the strong properties of self-scaled barriers, and with symmetric primal–dual methods for general convex cones.