Book contents
- Immunopsychiatry
- Immunopsychiatry
- Copyright page
- Contents
- Foreword
- Contributors
- Chapter 1 Basic Concepts in Immunobiology
- Chapter 2 From Psychoneuroimmunology to Immunopsychiatry: An Historical Perspective
- Chapter 3 Stress, Immune System and the Brain
- Chapter 4 The Role of Prenatal and Childhood Infection and Inflammation in Schizophrenia
- Chapter 5 The Role of Autoimmune Encephalitis in Immunopsychiatry and Lessons from Neuropsychiatric Systemic Lupus Erythematosus
- Chapter 6 Effectiveness of Immunotherapies for Psychotic Disorders
- Chapter 7 Inflammation, Sickness Behaviour and Depression
- Chapter 8 Immunotherapies for Depression
- Chapter 9 The Effect of Systemic Inflammation on Cognitive Function and Neurodegenerative Disease
- Chapter 10 Role of Inflammation in Lewy Body Dementia
- Chapter 11 The Role of Adaptive and Innate Immunity in Alzheimer’s Disease
- Chapter 12 The Immune System and Anxiety Disorders
- Chapter 13 Microbiome-Gut-Brain Interactions in Neurodevelopmental Disorders: Focus on Autism and Schizophrenia
- Chapter 14 Depression and the Adaptive Immune System
- Chapter 15 Transdiagnostic Features of the Immune System in Major Depressive Disorder, Bipolar Disorder and Schizophrenia
- Index
- Plate Section (PDF Only)
- References
Chapter 15 - Transdiagnostic Features of the Immune System in Major Depressive Disorder, Bipolar Disorder and Schizophrenia
Published online by Cambridge University Press: 02 September 2021
- Immunopsychiatry
- Immunopsychiatry
- Copyright page
- Contents
- Foreword
- Contributors
- Chapter 1 Basic Concepts in Immunobiology
- Chapter 2 From Psychoneuroimmunology to Immunopsychiatry: An Historical Perspective
- Chapter 3 Stress, Immune System and the Brain
- Chapter 4 The Role of Prenatal and Childhood Infection and Inflammation in Schizophrenia
- Chapter 5 The Role of Autoimmune Encephalitis in Immunopsychiatry and Lessons from Neuropsychiatric Systemic Lupus Erythematosus
- Chapter 6 Effectiveness of Immunotherapies for Psychotic Disorders
- Chapter 7 Inflammation, Sickness Behaviour and Depression
- Chapter 8 Immunotherapies for Depression
- Chapter 9 The Effect of Systemic Inflammation on Cognitive Function and Neurodegenerative Disease
- Chapter 10 Role of Inflammation in Lewy Body Dementia
- Chapter 11 The Role of Adaptive and Innate Immunity in Alzheimer’s Disease
- Chapter 12 The Immune System and Anxiety Disorders
- Chapter 13 Microbiome-Gut-Brain Interactions in Neurodevelopmental Disorders: Focus on Autism and Schizophrenia
- Chapter 14 Depression and the Adaptive Immune System
- Chapter 15 Transdiagnostic Features of the Immune System in Major Depressive Disorder, Bipolar Disorder and Schizophrenia
- Index
- Plate Section (PDF Only)
- References
Summary
Defining current psychopathology and optimum treatment selection in psychiatry relies solely on clinical symptom assessment but does not consider underlying biological correlates of psychiatric disorders. In particular, dysregulation of neurotransmitter metabolism and function (1,2), neuroendocrine pathways (3,4) and brain plasticity (5, 6) have been consistently reported across psychiatric disorders. Growing evidence points to a significant role of chronic low-grade inflammation in the pathophysiology of neuropsychiatric disorders such as major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BD) (7–10). This features immune system dysfunctions including alterations in immune cell regulation (10), complement system (11–14), cytokine (15–18) and chemokine (7,8) pathways. As a result, current and conventional therapeutic strategies are not optimally positioned, with low remission and high relapse rates amongst individuals and treatment resistant numbers being high. Hence, the immune system is becoming a suitable target in personalizing treatment of psychiatric disorders. Unclear as yet is whether, unique immunological signatures exist for different psychiatric disorders including MDD, SCZ and BD and how these originate. Clearly a better characterization of the underlying biological aetiology will lead towards a more personalized and targeted approach.
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- Information
- Textbook of Immunopsychiatry , pp. 309 - 335Publisher: Cambridge University PressPrint publication year: 2021