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Section 7 - Pathology of Multiple Gestations

Published online by Cambridge University Press:  03 September 2018

Raymond W. Redline
Affiliation:
Case Western Reserve University, Ohio
Theonia K. Boyd
Affiliation:
Harvard Medical School, Boston
Drucilla J. Roberts
Affiliation:
Harvard Medical School, Boston
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Publisher: Cambridge University Press
Print publication year: 2017

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References

References

Sherer, DM. Adverse perinatal outcome of twin pregnancies according to chorionicity: review of the literature. Am J Perinatol. 2001;18:2337.Google Scholar
Souter, VL, Kapur, RP, Nyholt, DR, Skogerboe, K, Myerson, D, Ton, CC, Opheim, KE, Easterling, TR, Shields, LE, Montgomery, GW, Glass, IA. A report of dizygous monochorionic twins. N Engl J Med. 2003;349:154–8.Google Scholar
Chen, K, Chmait, RH, Vanderbilt, D, Wu, S, Randolph, L. Chimerism in monochorionic dizygotic twins: case study and review. American journal of medical genetics Part A. 2013;161A:1817–24.Google Scholar
Hall, JG. Twinning. Lancet. 2003;362:735–43.CrossRefGoogle ScholarPubMed
Benirschke, K, Kim, CK. Multiple pregnancy. 1. N Engl J Med. 1973;288:1276–84.Google Scholar
McNamara, HC, Kane, SC, Craig, JM, Short, RV, Umstad, MP. A review of the mechanisms and evidence for typical and atypical twinning. Am J Obstet Gynecol. 2016;214:172–91.CrossRefGoogle ScholarPubMed
Herranz, G. The timing of monozygotic twinning: a criticism of the common model. Zygote. 2015;23:2740.CrossRefGoogle ScholarPubMed
Sills, ES, Moomjy, M, Zaninovic, N, Veeck, LL, McGee, M, Palermo, GD, Rosenwaks, Z. Human zona pellucida micromanipulation and monozygotic twinning frequency after IVF. Hum Reprod. 2000;15:890–5.Google Scholar
Schachter, M, Raziel, A, Friedler, S, Strassburger, D, Bern, O, Ron-El, R. Monozygotic twinning after assisted reproductive techniques: a phenomenon independent of micromanipulation. Hum Reprod. 2001;16:1264–9.CrossRefGoogle ScholarPubMed
Milki, AA, Jun, SH, Hinckley, MD, Behr, B, Giudice, LC, Westphal, LM. Incidence of monozygotic twinning with blastocyst transfer compared to cleavage-stage transfer. Fertility and sterility. 2003;79:503–06.Google Scholar
Sills, ES, Tucker, MJ, Palermo, GD. Assisted reproductive technologies and monozygous twins: implications for future study and clinical practice. Twin research : the official journal of the International Society for Twin Studies. 2000;3:217–23.Google Scholar
Alikani, M, Noyes, N, Cohen, J, Rosenwaks, Z. Monozygotic twinning in the human is associated with the zona pellucida architecture. Hum Reprod. 1994;9:1318–21.Google Scholar
Blickstein, I, Verhoeven, HC, Keith, LG. Zygotic splitting after assisted reproduction. N Engl J Med. 1999;340:738–9.CrossRefGoogle ScholarPubMed
Machin, G. Familial monozygotic twinning: a report of seven pedigrees. Am J Med Genet C Semin Med Genet. 2009;151 C:152–4.Google Scholar
Shur, N. The genetics of twinning: from splitting eggs to breaking paradigms. Am J Med Genet C Semin Med Genet. 2009;151 C:105–09.Google Scholar
Paepe, ME. Examination of the twin placenta. Semin Perinatol. 2015;39:2735.Google Scholar
Pinar, H, Sung, CJ, Oyer, CE, Singer, DB. Reference values for singleton and twin placental weights. Pediatr Pathol Lab Med. 1996;16:901–07.Google Scholar
De Paepe, ME, Shapiro, S, Young, LE, Luks, FI. Placental weight, birth weight and fetal:placental weight ratio in dichorionic and monochorionic twin gestations in function of gestational age, cord insertion type and placental partition. Placenta. 2015;36:213–20.Google Scholar
Denbow, ML, Cox, P, Taylor, M, Hammal, DM, Fisk, NM. Placental angioarchitecture in monochorionic twin pregnancies: relationship to fetal growth, fetofetal transfusion syndrome, and pregnancy outcome. Am J Obstet Gynecol. 2000;182:417–26.CrossRefGoogle ScholarPubMed
Lewi, L, Cannie, M, Blickstein, I, Jani, J, Huber, A, Hecher, K, Dymarkowski, S, Gratacos, E, Lewi, P, Deprest, J. Placental sharing, birthweight discordance, and vascular anastomoses in monochorionic diamniotic twin placentas. Am J Obstet Gynecol. 2007;197:587 e581–8.Google Scholar
De Paepe, ME, Burke, S, Luks, FI, Pinar, H, Singer, DB. Demonstration of placental vascular anatomy in monochorionic twin gestations. Pediatr Dev Pathol. 2002;5:3744.Google Scholar
Lopriore, E, Slaghekke, F, Middeldorp, JM, Klumper, FJ, van Lith, JM, Walther, FJ, Oepkes, D. Accurate and simple evaluation of vascular anastomoses in monochorionic placenta using colored dye, Journal of visualized experiments : JoVE 2011;e3208.CrossRefGoogle Scholar
Machin, G. Non-identical monozygotic twins, intermediate twin types, zygosity testing, and the non-random nature of monozygotic twinning: a review. Am J Med Genet C Semin Med Genet. 2009;151 C:110–27.Google Scholar
Hubinont, C, Lewi, L, Bernard, P, Marbaix, E, Debieve, F, Jauniaux, E. Anomalies of the placenta and umbilical cord in twin gestations. Am J Obstet Gynecol. 2015;213:S91S102.CrossRefGoogle ScholarPubMed
Sebire, NJ, Snijders, RJ, Hughes, K, Sepulveda, W, Nicolaides, KH. The hidden mortality of monochorionic twin pregnancies. Br J Obstet Gynaecol. 1997;104:1203–07.Google Scholar
Dias, T, Mahsud-Dornan, S, Bhide, A, Papageorghiou, AT, Thilaganathan, B. Cord entanglement and perinatal outcome in monoamniotic twin pregnancies. Ultrasound Obstet Gynecol. 2010;35:201–04.CrossRefGoogle ScholarPubMed
Hack, KE, Derks, JB, Elias, SG, Franx, A, Roos, EJ, Voerman, SK, Bode, CL, Koopman-Esseboom, C, Visser, GH. Increased perinatal mortality and morbidity in monochorionic versus dichorionic twin pregnancies: clinical implications of a large Dutch cohort study. BJOG. 2008;115:5867.CrossRefGoogle ScholarPubMed
Lewi, L, Jani, J, Blickstein, I, Huber, A, Gucciardo, L, Van Mieghem, T, Done, E, Boes, AS, Hecher, K, Gratacos, E, Lewi, P, Deprest, J. The outcome of monochorionic diamniotic twin gestations in the era of invasive fetal therapy: a prospective cohort study. Am J Obstet Gynecol. 2008;199:514 e511–18.Google ScholarPubMed
Simpson, LL. Twin-twin transfusion syndrome. Am J Obstet Gynecol. 2013;208:318.CrossRefGoogle ScholarPubMed
Quintero, RA, Morales, WJ, Allen, MH, Bornick, PW, Johnson, PK, Kruger, M. Staging of twin-twin transfusion syndrome. J Perinatol. 1999;19:550–5.Google Scholar
Senat, MV, Deprest, J, Boulvain, M, Paupe, A, Winer, N, Ville, Y. Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome. N Engl J Med. 2004;351:136–44.CrossRefGoogle ScholarPubMed
Bahtiyar, MO, Dulay, AT, Weeks, BP, Friedman, AH, Copel, JA. Prevalence of congenital heart defects in monochorionic/diamniotic twin gestations: a systematic literature review, Journal of ultrasound in medicine. J Ultrasound Med. 2007;26:1491–8.Google Scholar
Karatza, AA, Wolfenden, JL, Taylor, MJ, Wee, L, Fisk, NM, Gardiner, HM. Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies. Heart. 2002;88: 271–7.Google Scholar
Michelfelder, E, Gottliebson, W, Border, W, Kinsel, M, Polzin, W, Livingston, J, Khoury, P, Crombleholme, T. Early manifestations and spectrum of recipient twin cardiomyopathy in twin-twin transfusion syndrome: relation to Quintero stage. Ultrasound Obstet Gynecol. 2007;30:965–71.Google Scholar
Rychik, J, Tian, Z, Bebbington, M, Xu, F, McCann, M, Mann, S, Wilson, RD, Johnson, MP. The twin-twin transfusion syndrome: spectrum of cardiovascular abnormality and development of a cardiovascular score to assess severity of disease. Am J Obstet Gynecol. 2007;197:392 e391–8.Google Scholar
Habli, M, Michelfelder, E, Cnota, J, Wall, D, Polzin, W, Lewis, D, Lim, FY, Crombleholme, TM. Prevalence and progression of recipient-twin cardiomyopathy in early-stage twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2012;39:63–8.Google Scholar
Lopriore, E, Oepkes, D. Fetal and neonatal haematological complications in monochorionic twins. Semin Fetal Neonatal Med. 2008;13:231–8.Google Scholar
De Paepe, ME, Luks, FI. What-and why-the pathologist should know about twin-to-twin transfusion syndrome. Pediatr Dev Pathol. 2013;16:237–51.CrossRefGoogle ScholarPubMed
Mahieu-Caputo, D, Meulemans, A, Martinovic, J, Gubler, MC, Delezoide, AL, Muller, F, Madelenat, P, Fisk, NM, Dommergues, M. Paradoxic activation of the renin-angiotensin system in twin-twin transfusion syndrome: an explanation for cardiovascular disturbances in the recipient. Pediatr Res. 2005;58:685–8.Google Scholar
Fisk, NM, Duncombe, GJ, Sullivan, MH. The basic and clinical science of twin-twin transfusion syndrome. Placenta. 2009;30:379–90.Google Scholar
Bajoria, R, Ward, S, Chatterjee, R. Brain natriuretic peptide and endothelin-1 in the pathogenesis of polyhydramnios-oligohydramnios in monochorionic twins. Am J Obstet Gynecol. 2003;189:189–94.Google Scholar
Couck, I, Lewi, L. The Placenta in twin-to-twin transfusion syndrome and twin anemia polycythemia sequence. Twin Res Hum Genet. 2016;19:184–90.Google Scholar
De Paepe, ME, Shapiro, S, Greco, D, Luks, VL, Abellar, RG, Luks, CH, Luks, FI. Placental markers of twin-to-twin transfusion syndrome in diamniotic-monochorionic twins: A morphometric analysis of deep artery-to-vein anastomoses. Placenta. 2010;31:269–76.Google Scholar
Lewi, L, Deprest, J, Hecher, K. The vascular anastomoses in monochorionic twin pregnancies and their clinical consequences. Am J Obstet Gynecol. 2013;208:1930.CrossRefGoogle ScholarPubMed
Bertrand, S, De Paepe, M, Vigeant, C, Yale, JF. Prevention of adoptive transfer in BB rats by prophylactic insulin treatment. Diabetes. 1992;41:1273–7.Google Scholar
Zhao, DP, Cambiaso, O, Otano, L, Lewi, L, Deprest, J, Sun, LM, Duan, T, Oepkes, D, Shapiro, S, De Paepe, ME, Lopriore, E. Veno-venous anastomoses in twin-twin transfusion syndrome: A multicenter study. Placenta. 2015;36:911–14.Google Scholar
de Villiers, SF, Zhao, DP, Cohen, D, van Zwet, EW, Duan, T, Oepkes, D, Lopriore, E. Correlation between veno-venous anastomoses, TTTS and perinatal mortality in monochorionic twin pregnancies. Placenta. 2015;36:603–06.Google Scholar
van den Wijngaard, JP, van Gemert, MJ, Lopriore, E, Vandenbussche, FP, Nikkels, PG, Vanbavel, E. Case report: twin-to-twin transfusion syndrome resulting from placental collateral artery development. Placenta. 2008;29:220–3.Google Scholar
Berghella, V, Kaufmann, M. Natural history of twin-twin transfusion syndrome. J Reprod Med. 2001;46:480–4.Google Scholar
Gul, A, Aslan, H, Polat, I, Cebeci, A, Bulut, H, Sahin, O, Ceylan, Y. Natural history of 11 cases of twin-twin transfusion syndrome without intervention. Twin Res. 2003;6:263–6.Google Scholar
van Heteren, CF, Nijhuis, JG, Semmekrot, BA, Mulders, LG, van den Berg, PP. Risk for surviving twin after fetal death of co-twin in twin-twin transfusion syndrome. Obstet Gynecol. 1998;92:215–19.Google ScholarPubMed
Ong, SS, Zamora, J, Khan, KS, Kilby, MD. Prognosis for the co-twin following single-twin death: a systematic review. BJOG. 2006;113:992–8.Google Scholar
Chalouhi, GE, Stirnemann, JJ, Salomon, LJ, Essaoui, M, Quibel, T, Ville, Y. Specific complications of monochorionic twin pregnancies: twin-twin transfusion syndrome and twin reversed arterial perfusion sequence. Semin Fetal Neonatal Med. 2010;15:349–56.Google Scholar
Ahmed, S, Luks, FI, O’Brien, BM, Muratore, CS, Carr, SR. Influence of experience, case load, and stage distribution on outcome of endoscopic laser surgery for TTTS–a review. Prenat Diagn. 2010;30:314–19.Google Scholar
De Paepe, ME, Friedman, RM, Poch, M, Hansen, K, Carr, SR, Luks, FI. Placental findings after laser ablation of communicating vessels in twin-to-twin transfusion syndrome. Pediatr Dev Pathol. 2004;7:159–65.Google Scholar
Lewi, L, Jani, J, Cannie, M, Robyr, R, Ville, Y, Hecher, K, Gratacos, E, Vandecruys, H, Vandecaveye, V, Dymarkowski, S, Deprest, J. Intertwin anastomoses in monochorionic placentas after fetoscopic laser coagulation for twin-to-twin transfusion syndrome: is there more than meets the eye?. Am J Obstet Gynecol. 2006;194:790–5.Google Scholar
Lopriore, E, Slaghekke, F, Middeldorp, JM, Klumper, FJ, Oepkes, D, Vandenbussche, FP. Residual anastomoses in twin-to-twin transfusion syndrome treated with selective fetoscopic laser surgery: localization, size, and consequences. Am J Obstet Gynecol. 2009;201:66 e61–4.Google Scholar
Robyr, R, Lewi, L, Salomon, LJ, Yamamoto, M, Bernard, JP, Deprest, J, Ville, Y. Prevalence and management of late fetal complications following successful selective laser coagulation of chorionic plate anastomoses in twin-to-twin transfusion syndrome. Am J Obstet Gynecol. 2006;194:796803.Google Scholar
Slaghekke, F, Lopriore, E, Lewi, L, Middeldorp, JM, van Zwet, EW, Weingertner, AS, Klumper, FJ, DeKoninck, P, Devlieger, R, Kilby, MD, Rustico, MA, Deprest, J, Favre, R, Oepkes, D. Fetoscopic laser coagulation of the vascular equator versus selective coagulation for twin-to-twin transfusion syndrome: an open-label randomised controlled trial. Lancet. 2014;383:2144–51.Google Scholar
Tollenaar, LS, Slaghekke, F, Middeldorp, JM, Klumper, FJ, Haak, MC, Oepkes, D, Lopriore, E. Twin Anemia polycythemia sequence: Current views on pathogenesis, diagnostic criteria, perinatal management, and outcome. Twin Res Hum Genet. 2016;19(3):222–33.Google Scholar
Slaghekke, F, Pasman, S, Veujoz, M, Middeldorp, JM, Lewi, L, Devlieger, R, Favre, R, Lopriore, E, Oepkes, D. Middle cerebral artery peak systolic velocity to predict fetal hemoglobin levels in twin anemia-polycythemia sequence. Ultrasound Obstet Gynecol. 2015;46:432–6.Google Scholar
Lopriore, E, Slaghekke, F, Oepkes, D, Middeldorp, JM, Vandenbussche, FP, Walther, FJ. Hematological characteristics in neonates with twin anemia-polycythemia sequence (TAPS). Prenat Diagn. 2010;30:251–5.Google Scholar
Kusanovic, JP, Romero, R, Gotsch, F, Mittal, P, Erez, O, Kim, CJ, Hassan, SS, Espinoza, J, Yeo, L. Discordant placental echogenicity: a novel sign of impaired placental perfusion in twin-twin transfusion syndrome?. J Matern Fetal Neonatal Med. 2010;23:103–06.CrossRefGoogle ScholarPubMed
Weingertner, AS, Kohler, A, Kohler, M, Bouffet, N, Hunsinger, MC, Mager, C, Hornecker, F, Neumann, M, Schmerber, E, Tanghe, M, Viville, B, Favre, R. Clinical and placental characteristics in four new cases of twin anemia-polycythemia sequence. Ultrasound Obstet Gynecol. 2010;35:490–4.Google Scholar
Tollenaar, LS, Zhao, DP, Middeldorp, JM, Slaghekke, F, Oepkes, D, Lopriore, E. Color difference in placentas with twin anemia-polycythemia sequence: An additional diagnostic criterion? Fetal Diagn Ther. 2016;40:123–7.Google Scholar
Takeuchi, M, Maruyama, H, Oura, N, Kanazawa, A, Nakata, Y, Minami, S, Kikkawa, K. Erythroblastosis of the donor twin of twin anemia-polycythemia sequence. Acta medica Okayama. 2016;70:269–72.Google Scholar
Lopriore, E, Deprest, J, Slaghekke, F, Oepkes, D, Middeldorp, JM, Vandenbussche, FP, Lewi, L. Placental characteristics in monochorionic twins with and without twin anemia-polycythemia sequence. Obstet Gynecol. 2008;112:753–8.Google Scholar
van den Wijngaard, JP, Lewi, L, Lopriore, E, Robyr, R, Middeldorp, JM, Vandenbussche, FP, Devlieger, R, Deprest, J, Ville, Y, van Gemert, MJ. Modeling severely discordant hematocrits and normal amniotic fluids after incomplete laser therapy in twin-to-twin transfusion syndrome. Placenta. 2007;28:611–15.Google Scholar
de Villiers, S, Slaghekke, F, Middeldorp, JM, Klumper, FJ, Walther, FJ, Oepkes, D, Lopriore, E. Arterio-arterial vascular anastomoses in monochorionic twin placentas with and without twin anemia-polycythemia sequence. Placenta. 2012;33:227–9.Google Scholar
de Villiers, SF, Slaghekke, F, Middeldorp, JM, Walther, FJ, Oepkes, D, Lopriore, E. Placental characteristics in monochorionic twins with spontaneous versus post-laser twin anemia-polycythemia sequence. Placenta. 2013;34:456–9.Google Scholar
Slaghekke, F, Kist, WJ, Oepkes, D, Pasman, SA, Middeldorp, JM, Klumper, FJ, Walther, FJ, Vandenbussche, FP, Lopriore, E. Twin anemia-polycythemia sequence: diagnostic criteria, classification, perinatal management and outcome. Fetal Diagn Ther. 2010;27:181–90.Google Scholar
Luminoso, D, Figueira, CO, Marins, M, Peralta, CF. Fetal brain lesion associated with spontaneous twin anemia-polycythemia sequence. Ultrasound Obstet Gynecol. 2013;42:721–2.CrossRefGoogle ScholarPubMed
Gillim, DL, Hendricks, CH. Holoacardius; review of the literature and case report. Obstet Gynecol. 1953;2:647–53.Google Scholar
Kappelman, M. A cardius amorphus. Am J Obstet Gynecol. 1944;47:412–16.Google Scholar
James, WH. A note on the epidemiology of acardiac monsters. Teratology. 1977;16:211–16.Google Scholar
Moore, TR, Gale, S, Benirschke, K. Perinatal outcome of forty-nine pregnancies complicated by acardiac twinning. Am J Obstet Gynecol. 1990;163:907–12.Google Scholar
Healey, MG. Acardia: predictive risk factors for the co-twin’s survival. Teratology. 1994;50:205–13.CrossRefGoogle ScholarPubMed
Lewi, L, Gratacos, E, Ortibus, E, Van Schoubroeck, D, Carreras, E, Higueras, T, Perapoch, J, Deprest, J. Pregnancy and infant outcome of 80 consecutive cord coagulations in complicated monochorionic multiple pregnancies. Am J Obstet Gynecol. 2006;194: 782–9.Google Scholar
Livingston, JC, Lim, FY, Polzin, W, Mason, J, Crombleholme, TM. Intrafetal radiofrequency ablation for twin reversed arterial perfusion (TRAP): a single-center experience. Am J Obstet Gynecol. 2007;197:399 e391–3.Google Scholar
Van Allen, MI, Smith, DW, Shepard, TH. Twin reversed arterial perfusion (TRAP) sequence: a study of 14 twin pregnancies with acardius. Semin Perinatol. 1983;7: 285–93.Google ScholarPubMed
De Groot, R, Van Den Wijngaard, JP, Umur, A, Beek, JF, Nikkels, PG, Van Gemert, MJ. Modeling acardiac twin pregnancies. Ann N Y Acad Sci. 2007;1101:235–49.Google Scholar
Sato, T, Kaneko, K, Konuma, S, Sato, I, Tamada, T. Acardiac anomalies: review of 88 cases in Japan. Asia Oceania J Obstet Gynaecol. 1984;10(1):4552.Google Scholar
Weber, MA, Sebire, NJ. Genetics and developmental pathology of twinning. Semin Fetal Neonatal Med. 2010;15:313–18.Google Scholar
Buntinx, IM, Bourgeois, N, Buytaert, PM, Dumon, JE. Acardiac amorphous twin with prune belly sequence in the co-twin. Am J Med Genet. 1991;39:453–7.Google Scholar
Arias, F, Sunderji, S, Gimpelson, R, Colton, E. Treatment of acardiac twinning. Obstet Gynecol. 1998;91:818–21.Google Scholar
De Paepe, ME, Shapiro, S, Young, L, Luks, FI. Placental characteristics of selective birth weight discordance in diamniotic-monochorionic twin gestations. Placenta. 2010;31:380–6.CrossRefGoogle ScholarPubMed
Fick, AL, Feldstein, VA, Norton, ME, Wassel Fyr, C, Caughey, AB, Machin, GA. Unequal placental sharing and birth weight discordance in monochorionic diamniotic twins. Am J Obstet Gynecol. 2006;195:178–83.Google Scholar
Valsky, DV, Eixarch, E, Martinez, JM, Crispi, F, Gratacos, E. Selective intrauterine growth restriction in monochorionic twins: pathophysiology, diagnostic approach and management dilemmas. Semin Fetal Neonatal Med. 2010;15:342–8.Google Scholar
Yinon, Y, Ben Meir, E, Berezowsky, A, Weisz, B, Schiff, E, Mazaki-Tovi, S, Lipitz, S. Circulating angiogenic factors in monochorionic twin pregnancies complicated by twin-to-twin transfusion syndrome and selective intrauterine growth restriction. Am J Obstet Gynecol. 2014;210:141 e141–7.Google Scholar
Lewi, L, Gucciardo, L, Huber, A, Jani, J, Van Mieghem, T, Done, E, Cannie, M, Gratacos, E, Diemert, A, Hecher, K, Lewi, P, Deprest, J. Clinical outcome and placental characteristics of monochorionic diamniotic twin pairs with early- and late-onset discordant growth. Am J Obstet Gynecol. 2008;199:511 e511–17.Google Scholar
Umur, A, van Gemert, MJ, Nikkels, PG. Monoamniotic-versus diamniotic-monochorionic twin placentas: anastomoses and twin-twin transfusion syndrome. Am J Obstet Gynecol. 2003;189:1325–9.Google Scholar
Hack, KE, Derks, JB, Schaap, AH, Lopriore, E, Elias, SG, Arabin, B, Eggink, AJ, Sollie, KM, Mol, BW, Duvekot, HJ, Willekes, C, Go, AT, Koopman-Esseboom, C, Vandenbussche, FP, Visser, GH. Perinatal outcome of monoamniotic twin pregnancies. Obstet Gynecol. 2009;113:353–60.Google Scholar
Diehl, W, Glosemeyer, P, Tavares De Sousa, M, Hollwitz, B, Ortmeyer, G, Hecher, K. Twin anemia-polycythemia sequence in a case of monoamniotic twins. Ultrasound Obstet Gynecol. 2013;42:108–11.Google Scholar
Gilbert-Barness, E, Debich-Spicer, D, Opitz, JM. Conjoined twins: morphogenesis of the heart and a review. AM J Med Genet A. 2003;120A:568–82.Google Scholar
Spitz, L. Conjoined twins. Prenat Diagn. 2005;25:814–19.Google Scholar
Kapur, RP, Jack, RM, Siebert, JR. Diamniotic placentation associated with omphalopagus conjoined twins: implications for a contemporary model of conjoined twinning. Am J Med Genet. 1994;52:188–95.Google Scholar
Cordero, L, Franco, A, Joy, SD. Monochorionic monoamniotic twins: neonatal outcome. J Perinatol. 2006;26:170–5.Google Scholar
Baxi, LV, Walsh, CA. Monoamniotic twins in contemporary practice: a single-center study of perinatal outcomes. J Matern Fetal Neonatal Med. 2010;23:506–10.Google Scholar
Metneki, J, Czeizel, A. Conjoined twins in Hungary, 1970–1986. Acta Genet Med Gemellol (Roma). 1989;38:285–99.Google Scholar
Conjoined twins–an epidemiological study based on 312 cases. The international clearinghouse for birth defects monitoring systems. Acta Genet Med Gemellol (Roma). 1991;40:325–35.Google Scholar

References

Kulkarni, AD, Jamieson, DJ, Jones, HW Jr., Kissin, DM, Gallo, MF, Macaluso, M, Adashi, EY. Fertility treatments and multiple births in the United States. N Engl J Med. 2013;369:2218–25.Google Scholar
Hoekstra, C, Zhao, ZZ, Lambalk, CB, Willemsen, G, Martin, NG, Boomsma, DI, Montgomery, GW. Dizygotic twinning. Human reprod update. 2008;14:3747.Google Scholar
Hall, JG. Twinning. Lancet. 2003;362:735–43.Google Scholar
Smits, J, Monden, C. Twinning across the developing world. PLoS One. 2011;6:e25239.CrossRefGoogle ScholarPubMed
Montgomery, GW, Zhao, ZZ, Marsh, AJ, Mayne, R, Treloar, SA, James, M, Martin, NG, Boomsma, DI, Duffy, DL. A deletion mutation in GDF9 in sisters with spontaneous DZ twins. Twin Res. 2004;7:548–55.Google Scholar
Palmer, JS, Zhao, ZZ, Hoekstra, C, Hayward, NK, Webb, PM, Whiteman, DC, Martin, NG, Boomsma, DI, Duffy, DL, Montgomery, GW. Novel variants in growth differentiation factor 9 in mothers of dizygotic twins. J Clin Endocrinol Metab. 2006;91:4713–6.Google Scholar
Mbarek, H, Steinberg, S, Nyholt, DR, Gordon, SD, Miller, MB, McRae, AF, Hottenga, JJ, Day, FR, Willemsen, G, de Geus, EJ, Davies, GE, Martin, HC, Penninx, BW, Jansen, R, McAloney, K, Vink, JM, Kaprio, J, Plomin, R, Spector, TD, Magnusson, PK, Reversade, B, Harris, RA, Aagaard, K, Kristjansson, RP, Olafsson, I, Eyjolfsson, GI, Sigurdardottir, O, Iacono, WG, Lambalk, CB, Montgomery, GW, McGue, M, Ong, KK, Perry, JR, Martin, NG, Stefansson, H, Stefansson, K, Boomsma, DI. Identification of common genetic variants influencing spontaneous dizygotic twinning and female fertility. American journal of human genetics. 2016;98:898908.Google Scholar
Phelan, MC, Geer, JS, Blackburn, WR. Vascular anastomoses leading to amelia and cutis aplasia in a dizygotic twin pregnancy. Clin Genet. 1998;53:126–30.Google Scholar
van Dijk, BA, Boomsma, DI, de Man, AJ. Blood group chimerism in human multiple births is not rare. Am J Med Genet. 1996;61:264–8.Google Scholar
Pinar, H, Sung, CJ, Oyer, CE, Singer, DB. Reference values for singleton and twin placental weights. Pediatr Pathol Lab Med. 1996;16:901–7.Google Scholar
De Paepe, ME, Shapiro, S, Young, LE, Luks, FI. Placental weight, birth weight and fetal:placental weight ratio in dichorionic and monochorionic twin gestations in function of gestational age, cord insertion type and placental partition. Placenta. 2015;36:213–20.Google Scholar
Zech, NH, Wisser, J, Natalucci, G, Riegel, M, Baumer, A, Schinzel, A. Monochorionic-diamniotic twins discordant in gender from a naturally conceived pregnancy through postzygotic sex chromosome loss in a 47,XXY zygote. Prenat Diagn. 2008;28:759–63.Google Scholar
Machin, G. Non-identical monozygotic twins, intermediate twin types, zygosity testing, and the non-random nature of monozygotic twinning: a review. Am J Med Genet C Semin Med Genet. 2009;151 C:110–27.Google Scholar
Qin, JB, Wang, H, Sheng, X, Xie, Q, Gao, S. Assisted reproductive technology and risk of adverse obstetric outcomes in dichorionic twin pregnancies: a systematic review and meta-analysis. Fertil Steril. 2016;105:1180–92.Google Scholar
Breathnach, FM, McAuliffe, FM, Geary, M, Daly, S, Higgins, JR, Dornan, J, Morrison, JJ, Burke, G, Higgins, S, Dicker, P, Manning, F, Mahony, R, Malone, FD. Definition of intertwin birth weight discordance. Obstet Gynecol. 2011;118:94103.Google Scholar
Kaponis, A, Thanatsis, N, Papadopoulos, V, Decavalas, G. Intertwin estimated fetal weight or crown rump length discordance and adverse perinatal outcome. J Perinat Med. 2016;44:863–9.Google Scholar
Lewi, L, Devlieger, R, De Catte, L, Deprest, J. Growth discordance. Best Pract Res Clin Obstet Gynaecol. 2014;28:295303.Google Scholar
D’Antonio, F, Khalil, A, Dias, T, Thilaganathan, B. Weight discordance and perinatal mortality in twins: analysis of the Southwest Thames Obstetric Research Collaborative (STORK) multiple pregnancy cohort. Ultrasound Obstet Gynecol. 2013;41:643–8.Google Scholar
Bristow, RE, Shumway, JB, Khouzami, AN, Witter, FR. Complete hydatidiform mole and surviving coexistent twin. Obstet Gynecol Surv. 1996;51:705–9.Google Scholar
Vaisbuch, E, Ben-Arie, A, Dgani, R, Perlman, S, Sokolovsky, N, Hagay, Z. Twin pregnancy consisting of a complete hydatidiform mole and co-existent fetus: report of two cases and review of literature. Gynecologic oncology. 2005;98:1923.Google Scholar
Sebire, NJ, Foskett, M, Paradinas, FJ, Fisher, RA, Francis, RJ, Short, D, Newlands, ES, Seckl, MJ. Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin. Lancet. 2002;359:2165–6.Google Scholar
Massardier, J, Golfier, F, Journet, D, Frappart, L, Zalaquett, M, Schott, AM, Lenoir, VT, Dupuis, O, Hajri, T, Raudrant, D. Twin pregnancy with complete hydatidiform mole and coexistent fetus: obstetrical and oncological outcomes in a series of 14 cases. Eur J Obstet Gynecol Reprod Biol. 2009;143:84–7.Google Scholar
Niemann, I, Bolund, L, Sunde, L. Twin pregnancies with diploid hydatidiform mole and co-existing normal fetus may originate from one oocyte. Hum Reprod. 2008;23:2031–5.Google Scholar
Makrydimas, G, Sebire, NJ, Thornton, SE, Zagorianakou, N, Lolis, D, Fisher, RA. Complete hydatidiform mole and normal live birth: a novel case of confined placental mosaicism: case report. Hum Reprod. 2002;17:2459–63.Google Scholar
Chao, AS, Tsai, TC, Soong, YK. Clinical management of a quadruplet pregnancy combining a triplet pregnancy with a classical hydatidiform mole: case report and review of literature. Prenat Diagn. 1999;19:1073–6.Google Scholar
Blumenfeld, Z, Dirnfeld, M, Abramovici, H, Amit, A, Bronshtein, M, Brandes, JM. Spontaneous fetal reduction in multiple gestations assessed by transvaginal ultrasound. Br J Obstet Gynaecol. 1992;99:333–7.Google Scholar
Landy, HJ, Keith, LG. The vanishing twin: a review. Human reprod update. 1998;4:177–83.Google Scholar
Oloyede, OA, Iketubosin, F, Bamgbopa, K. Spontaneous fetal reduction and early pregnancy complications in multiple pregnancies following in vitro fertilization. Int J Gynaecol Obstet. 2012;119:5760.CrossRefGoogle ScholarPubMed
Shek, NW, Hillman, SC, Kilby, MD. Single-twin demise: pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2014;28:249–63.CrossRefGoogle ScholarPubMed
Zhou, L, Gao, X, Wu, Y, Zhang, Z. Analysis of pregnancy outcomes for survivors of the vanishing twin syndrome after in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol. 2016;203:35–9.Google Scholar
Huang, T, Boucher, K, Aul, R, Rashid, S, Meschino, WS. First and second trimester maternal serum markers in pregnancies with a vanishing twin. Prenat Diagn. 2015;35:90–6.Google Scholar
Vlkova, B, Hodosy, J. Vanishing twin as a potential source of bias in non-invasive fetal sex determination: a case report. J Obstet Gynaecol Res. 2014;40:1128–31.Google Scholar
Masala, M, Saba, L, Zoppi, MA, Puddu, R, Picciau, A, Capponi, V, Iuculano, A, Monni, G, Rosatelli, MC. Pitfalls in noninvasive fetal RhD and sex determination due to a vanishing twin. Prenat Diagn. 2015;35:506–8.CrossRefGoogle ScholarPubMed
Daw, E. Fetus papyraceus–11 cases. Postgrad Med J. 1983;59:598600.Google Scholar
McNamara, HC, Kane, SC, Craig, JM, Short, RV, Umstad, MP. A review of the mechanisms and evidence for typical and atypical twinning. Am J Obstet Gynecol. 2016;214:172–91.Google Scholar
Callen, DF, Fernandez, H, Hull, YJ, Svigos, JM, Chambers, HM, Sutherland, GR. A normal 46,XX infant with a 46,XX/69,XXY placenta: a major contribution to the placenta is from a resorbed twin. Prenat Diagn. 1991;11:437–42.Google Scholar
Anand, D, Platt, MJ, Pharoah, PO. Comparative development of surviving co-twins of vanishing twin conceptions, twins and singletons. Twin Res Hum Genet. 2007;10:210–5.Google Scholar
Pinborg, A, Lidegaard, O, la Cour Freiesleben, N, Andersen, AN. Consequences of vanishing twins in IVF/ICSI pregnancies. Hum Reprod. 2005;20:2821–9.Google Scholar
Malinowski, W, Koktysz, R, Stawerski, P. The case of monochorionic twin gestation complicated by intrauterine demise of one fetus in the first trimester. Twin Res Hum Genet. 2005;8:262–6.Google Scholar
Marton, V, Zadori, J, Kozinszky, Z, Kereszturi, A. Prevalences and pregnancy outcome of vanishing twin pregnancies achieved by in vitro fertilization versus natural conception. Fertil Steril. 2016;106:13991406.Google Scholar
Ong, SS, Zamora, J, Khan, KS, Kilby, MD. Prognosis for the co-twin following single-twin death: a systematic review. BJOG. 2006;113:992–8.Google Scholar
Hillman, SC, Morris, RK, Kilby, MD. Co-twin prognosis after single fetal death: a systematic review and meta-analysis. Obstet Gynecol. 2011;118:928–40.Google Scholar
Shinwell, ES, Haklai, T, Eventov-Friedman, S. Outcomes of multiplets. Neonatology. 2009;95:614.Google Scholar
Martin, JA, Kung, HC, Mathews, TJ, Hoyert, DL, Strobino, DM, Guyer, B, Sutton, SR. Annual summary of vital statistics: 2006. Pediatrics. 2008;121:788801.Google Scholar
Schachter, M, Raziel, A, Friedler, S, Strassburger, D, Bern, O, Ron-El, R. Monozygotic twinning after assisted reproductive techniques: a phenomenon independent of micromanipulation. Hum Reprod. 2001;16:1264–9.Google Scholar
Papageorghiou, AT, Avgidou, K, Bakoulas, V, Sebire, NJ, Nicolaides, KH. Risks of miscarriage and early preterm birth in trichorionic triplet pregnancies with embryo reduction versus expectant management: new data and systematic review. Hum Reprod. 2006;21:1912–7.Google Scholar
Pinar, H, Stephens, M, Singer, DB, Boyd, TK, Pflueger, SM, Gang, DL, Roberts, DJ, Sung, CJ. Triplet placentas: reference values for weights. Pediatr Dev Pathol. 2002;5:495–8.Google Scholar
Luke, B, Keith, LG. The contribution of singletons, twins and triplets to low birth weight, infant mortality and handicap in the United States. J Reprod Med. 1992;37:661–6.Google Scholar
Alexander, GR, Kogan, M, Martin, J, Papiernik, E. What are the fetal growth patterns of singletons, twins, and triplets in the United States? Clin Obstet Gynecol. 1998;41:114–25.CrossRefGoogle ScholarPubMed
Blickstein, I. Growth aberration in multiple pregnancy. Obstet Gynecol Clin North Am. 2005;32:3954, viii.Google Scholar
Pharoah, PO, Cooke, T. Cerebral palsy and multiple births. Arch Dis Child Fetal Neonatal Ed. 1996;75:F174–7.CrossRefGoogle ScholarPubMed
Petterson, B, Nelson, KB, Watson, L, Stanley, F. Twins, triplets, and cerebral palsy in births in Western Australia in the 1980s. BMJ. 1993;307:1239–43.Google Scholar
Geipel, A, Berg, C, Katalinic, A, Plath, H, Hansmann, M, Germer, U, Gembruch, U. Prenatal diagnosis and obstetric outcomes in triplet pregnancies in relation to chorionicity. BJOG. 2005;112:554–8.Google Scholar
Abel, JS, Flock, A, Berg, C, Gembruch, U, Geipel, A. Expectant management versus multifetal pregnancy reduction in higher order multiple pregnancies containing a monochorionic pair and a review of the literature. Arch Gynecol Obstet. 2016;294(6):1167–73.Google Scholar
Lewi, L, Deprest, J, Hecher, K. The vascular anastomoses in monochorionic twin pregnancies and their clinical consequences. Am J Obstet Gynecol. 2013;208:1930.Google Scholar
Wen, SW, Demissie, K, Yang, Q, Walker, MC. Maternal morbidity and obstetric complications in triplet pregnancies and quadruplet and higher-order multiple pregnancies. Am J Obstet Gynecol. 2004;191:254–8.Google Scholar

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