Book contents
- Frontmatter
- Dedication
- Contents
- Preface
- Case 1 Dense basilar artery sign
- Case 2 Global anoxic brain injury
- Case 3 Acute infarction
- Case 4 Vertebral artery dissection
- Case 5 Subacute infarct
- Case 6 Subarachnoid hemorrhage
- Case 7 Intracranial aneurysms
- Case 8 Giant aneurysms
- Case 9 Acute intracerebral hematoma
- Case 10 Cerebral amyloid angiopathy
- Case 11 Primary CNS vasculitis
- Case 12 Reversible cerebral vasoconstriction syndrome
- Case 13 Moyamoya disease/syndrome
- Case 14 Cortical venous thrombosis
- Case 15 Developmental venous anomalies
- Case 16 Dural arteriovenous fistula
- Case 17 Cavernous malformation
- Case 18 Tumefactive demyelinating lesion
- Case 19 Acute disseminated encephalomyelitis
- Case 20 Progressive multifocal leukoencephalopathy
- Case 21 Osmotic myelinolysis
- Case 22 Neurosarcoidosis
- Case 23 Posterior fossa masses in children
- Case 24 Low-grade glioma
- Case 25 Diffuse intrinsic pontine glioma
- Case 26 Pseudoprogression of GBM
- Case 27 Pseudoresponse in treatment of GBM
- Case 28 Low-grade oligodendroglioma
- Case 29 Primary CNS lymphoma
- Case 30 Pineal region tumors
- Case 31 Intraventricular masses
- Case 32 Colloid cyst
- Case 33 Primary intraosseous meningioma
- Case 34 Suprasellar meningioma
- Case 35 Pituitary macroadenoma
- Case 36 Brain abscess
- Case 37 Neurocysticercosis
- Case 38 Tuberculosis
- Case 39 Creutzfeldt–Jakob disease
- Case 40 Herpes encephalitis
- Case 41 Wernicke’s encephalopathy
- Case 42 Hypertrophic olivary degeneration
- Case 43 Adrenoleukodystrophy
- Case 44 Mild traumatic brain injury
- Case 45 Isodense subdural hematoma
- Case 46 Posterior reversible encephalopathy syndrome
- Case 47 Late-onset adult hydrocephalus secondary to aqueductal stenosis
- Case 48 Intracranial hypotension
- Case 49 Idiopathic intracranial hypertension
- Case 50 Rathke’s cleft cyst
- Case 51 FLAIR sulcal hyperintensity secondary to general anesthesia
- Case 52 Virchow–Robin spaces
- Case 53 Arachnoid granulations
- Case 54 Benign external hydrocephalus
- Case 55 Pitfalls in CTA
- Case 56 Asymmetric pneumatization of the anterior clinoid process
- Case 57 Fibrous dysplasia of skull base
- Case 58 Sphenoid bone pseudolesion
- Case 59 Clival lesions
- Case 60 Perineural spread
- Case 61 Cochlear dysplasia
- Case 62 Labyrinthitis ossificans
- Case 63 Superior semicircular canal dehiscence
- Case 64 Fluid entrapment in the petrous apex cells
- Case 65 Acquired cholesteatoma
- Case 66 Malignant otitis externa
- Case 67 Temporal bone fractures
- Case 68 Allergic fungal sinusitis
- Case 69 Invasive fungal sinusitis
- Case 70 Spontaneous CSF leaks and sphenoid cephaloceles
- Case 71 Juvenile nasal angiofibroma
- Case 72 Idiopathic orbital pseudotumor
- Case 73 Optic neuritis
- Case 74 Intraparotid lymph nodes
- Case 75 Benign mixed tumor
- Case 76 First branchial cleft cyst
- Case 77 Nasopharyngeal cysts
- Case 78 Cystic nodal metastasis
- Case 79 Low-flow vascular malformations
- Case 80 Parapharyngeal masses
- Case 81 Third branchial apparatus anomaly
- Case 82 Parathyroid adenoma
- Case 83 String sign
- Case 84 Carotid artery dissection
- Case 85 Traumatic arterial injury
- Case 86 Craniovertebral junction injuries
- Case 87 Odontoid fractures
- Case 88 Vertebral compression fractures
- Case 89 Sacral insufficiency fracture
- Case 90 Paget’s disease of the spine
- Case 91 Renal osteodystrophy
- Case 92 Calcific tendinitis of the longus colli
- Case 93 T2 hyperintense disc herniation
- Case 94 Disc herniation and cord compression
- Case 95 Postoperative disc herniation versus postsurgical scarring
- Case 96 Degenerative endplate alterations
- Case 97 Spinal dysraphism
- Case 98 Tethered spinal cord
- Case 99 Chiari I malformation
- Case 100 Spinal vascular malformations
- Case 101 Cord compression
- Case 102 Demyelinating/inflammatory spinal cord lesion
- Case 103 Subacute combined degeneration
- Case 104 Intradural cyst
- Case 105 Spinal CSF leaks
- Case 106 Leptomeningeal drop metastases
- Index
- References
Case 18 - Tumefactive demyelinating lesion
Published online by Cambridge University Press: 18 December 2013
- Frontmatter
- Dedication
- Contents
- Preface
- Case 1 Dense basilar artery sign
- Case 2 Global anoxic brain injury
- Case 3 Acute infarction
- Case 4 Vertebral artery dissection
- Case 5 Subacute infarct
- Case 6 Subarachnoid hemorrhage
- Case 7 Intracranial aneurysms
- Case 8 Giant aneurysms
- Case 9 Acute intracerebral hematoma
- Case 10 Cerebral amyloid angiopathy
- Case 11 Primary CNS vasculitis
- Case 12 Reversible cerebral vasoconstriction syndrome
- Case 13 Moyamoya disease/syndrome
- Case 14 Cortical venous thrombosis
- Case 15 Developmental venous anomalies
- Case 16 Dural arteriovenous fistula
- Case 17 Cavernous malformation
- Case 18 Tumefactive demyelinating lesion
- Case 19 Acute disseminated encephalomyelitis
- Case 20 Progressive multifocal leukoencephalopathy
- Case 21 Osmotic myelinolysis
- Case 22 Neurosarcoidosis
- Case 23 Posterior fossa masses in children
- Case 24 Low-grade glioma
- Case 25 Diffuse intrinsic pontine glioma
- Case 26 Pseudoprogression of GBM
- Case 27 Pseudoresponse in treatment of GBM
- Case 28 Low-grade oligodendroglioma
- Case 29 Primary CNS lymphoma
- Case 30 Pineal region tumors
- Case 31 Intraventricular masses
- Case 32 Colloid cyst
- Case 33 Primary intraosseous meningioma
- Case 34 Suprasellar meningioma
- Case 35 Pituitary macroadenoma
- Case 36 Brain abscess
- Case 37 Neurocysticercosis
- Case 38 Tuberculosis
- Case 39 Creutzfeldt–Jakob disease
- Case 40 Herpes encephalitis
- Case 41 Wernicke’s encephalopathy
- Case 42 Hypertrophic olivary degeneration
- Case 43 Adrenoleukodystrophy
- Case 44 Mild traumatic brain injury
- Case 45 Isodense subdural hematoma
- Case 46 Posterior reversible encephalopathy syndrome
- Case 47 Late-onset adult hydrocephalus secondary to aqueductal stenosis
- Case 48 Intracranial hypotension
- Case 49 Idiopathic intracranial hypertension
- Case 50 Rathke’s cleft cyst
- Case 51 FLAIR sulcal hyperintensity secondary to general anesthesia
- Case 52 Virchow–Robin spaces
- Case 53 Arachnoid granulations
- Case 54 Benign external hydrocephalus
- Case 55 Pitfalls in CTA
- Case 56 Asymmetric pneumatization of the anterior clinoid process
- Case 57 Fibrous dysplasia of skull base
- Case 58 Sphenoid bone pseudolesion
- Case 59 Clival lesions
- Case 60 Perineural spread
- Case 61 Cochlear dysplasia
- Case 62 Labyrinthitis ossificans
- Case 63 Superior semicircular canal dehiscence
- Case 64 Fluid entrapment in the petrous apex cells
- Case 65 Acquired cholesteatoma
- Case 66 Malignant otitis externa
- Case 67 Temporal bone fractures
- Case 68 Allergic fungal sinusitis
- Case 69 Invasive fungal sinusitis
- Case 70 Spontaneous CSF leaks and sphenoid cephaloceles
- Case 71 Juvenile nasal angiofibroma
- Case 72 Idiopathic orbital pseudotumor
- Case 73 Optic neuritis
- Case 74 Intraparotid lymph nodes
- Case 75 Benign mixed tumor
- Case 76 First branchial cleft cyst
- Case 77 Nasopharyngeal cysts
- Case 78 Cystic nodal metastasis
- Case 79 Low-flow vascular malformations
- Case 80 Parapharyngeal masses
- Case 81 Third branchial apparatus anomaly
- Case 82 Parathyroid adenoma
- Case 83 String sign
- Case 84 Carotid artery dissection
- Case 85 Traumatic arterial injury
- Case 86 Craniovertebral junction injuries
- Case 87 Odontoid fractures
- Case 88 Vertebral compression fractures
- Case 89 Sacral insufficiency fracture
- Case 90 Paget’s disease of the spine
- Case 91 Renal osteodystrophy
- Case 92 Calcific tendinitis of the longus colli
- Case 93 T2 hyperintense disc herniation
- Case 94 Disc herniation and cord compression
- Case 95 Postoperative disc herniation versus postsurgical scarring
- Case 96 Degenerative endplate alterations
- Case 97 Spinal dysraphism
- Case 98 Tethered spinal cord
- Case 99 Chiari I malformation
- Case 100 Spinal vascular malformations
- Case 101 Cord compression
- Case 102 Demyelinating/inflammatory spinal cord lesion
- Case 103 Subacute combined degeneration
- Case 104 Intradural cyst
- Case 105 Spinal CSF leaks
- Case 106 Leptomeningeal drop metastases
- Index
- References
Summary
Imaging description
Demyelinating lesions are usually small and multiple. Occasionally demyelinating lesions can mimic neoplasms clinically, radiologically, and even histologically – hence the name tumefactive demyelinating lesion (TDL). TDLs usually present as large white matter lesions in the periventricular or subcortical regions [1]. In particular, solitary TDLs are often misdiagnosed as tumor, leading to unnecessary biopsy, surgery, and delay in treatment.
While TDLs show a spectrum of imaging abnormalities, certain features are commonly seen, and these help in differentiating TDLs from other lesions [2,3]. On CT, TDLs show hypoattenuation [4]. On post-contrast MRI, incomplete ring enhancement is a relatively characteristic feature, which may be present up to 70% of patients (Figs. 18.1, 18.2). The T2 signal is variable, but most lesions show a markedly increased T2 signal centrally and relatively decreased signal peripherally. Up to 50% of TDLs do not have mass effect or edema, which is a critical observation in differential diagnosis. When mass effect and/or edema present they are usually less pronounced than what would be expected from a high-grade glioma of similar size, although occasionally marked mass effect can be seen. Diffusion-weighted imaging (DWI) signal is also variable across the lesions, with central parts showing increased diffusivity and peripheral potions showing relative restricted diffusion (Fig. 18.1).
- Type
- Chapter
- Information
- Pearls and Pitfalls in Head and Neck and NeuroimagingVariants and Other Difficult Diagnoses, pp. 55 - 57Publisher: Cambridge University PressPrint publication year: 2013