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Chapter 6 - Low-grade and intermediate-grade malignant epithelial tumors of the thymus: thymomas

Published online by Cambridge University Press:  05 February 2015

Alberto M. Marchevsky
Affiliation:
Cedars-Sinai Medical Center, Los Angeles
Saul Suster
Affiliation:
Medical College of Wisconsin
Mark R. Wick
Affiliation:
University of Virginia Health System
Alberto M. Marchevsky
Affiliation:
Cedars-Sinai Medical Center, Los Angeles
Mark R. Wick
Affiliation:
University of Virginia
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Print publication year: 2000

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References

Shimosato, Y, Mukai, K, Matsuno, Y. Tumors of the Mediastinum. 2010; Washington: American Registry of Pathology.Google Scholar
Marchevsky, AM, Kaneko, M. Surgical Pathology of the Mediastinum. 1991; New York: Raven Press.Google Scholar
Marx, A, Muller-Hermelink, HK, Strobel, P. The role of thymomas in the development of myasthenia gravis. Ann N Y Acad Sci. 2003;998:223–36.CrossRefGoogle ScholarPubMed
Marx, A, Schultz, A, Wilisch, A et al. Paraneoplastic autoimmunity in thymus tumors. Dev Immunol. 1998;6:129–40.CrossRefGoogle ScholarPubMed
Marx, A, Willcox, N, Leite, MI et al. Thymoma and paraneoplastic myasthenia gravis. Autoimmunity. 2010;43:413–27.CrossRefGoogle ScholarPubMed
Levine, GD, Rosai, J. Thymic hyperplasia and neoplasia: a review of current concepts. Hum Pathol. 1978;9:495–515.CrossRefGoogle ScholarPubMed
Rosai, J. Thymomas, committees, and memory lapses. Am J Clin Pathol. 2011;135:648.CrossRefGoogle ScholarPubMed
Rosai, J. The pathology of thymic neoplasia. Monogr Pathol. 1987;161–83.
Finsterer, J, Mullauer, L. Is resection of a thymoma WHO A indicated in the absence of myasthenia gravis?Clin Ter. 2011;162:37–9.Google ScholarPubMed
Jain, RK, Mehta, RJ, Henley, JD et al. WHO types A and AB thymomas: not always benign. Mod Pathol. 2010;23:1641–9.CrossRefGoogle Scholar
Moran, CA, Kalhor, N, Suster, S. Invasive spindle cell thymomas (WHO Type A): a clinicopathologic correlation of 41 cases. Am J Clin Pathol. 2010;134:793–8.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA. Histologic classification of thymoma: the World Health Organization and beyond. Hematol Oncol Clin North Am. 2008;22:381–92.CrossRefGoogle ScholarPubMed
Suster, S. Problem areas and inconsistencies in the WHO classification of thymoma. Semin Diagn Pathol. 2005;22:188–97.CrossRefGoogle ScholarPubMed
Suster, S. Thymoma classification: current status and future trends. Am J Clin Pathol. 2006;125:542–54.CrossRefGoogle ScholarPubMed
Koksal, D, Bayiz, H, Mutluay, N et al. Fibrosing mediastinitis mimicking bronchogenic carcinoma. J Thorac Dis. 2013;5:E5–E7.Google ScholarPubMed
Strobel, P, Hohenberger, P, Marx, A. Thymoma and thymic carcinoma: molecular pathology and targeted therapy. J Thorac Oncol. 2010;5:S286–S290.CrossRefGoogle ScholarPubMed
Travis, WD, Brambilla, E, Muller-Hermelink, HK et al. Tumours of the Lung, Pleura, Thymus and Heart. 2004; Lyon: IARC Press.Google Scholar
LeGolvan, DP, Abell, MR. Thymomas. Cancer. 1977;39:2142–57.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Engels, EA. Epidemiology of thymoma and associated malignancies. J Thorac Oncol. 2010;5:S260–S265.CrossRefGoogle ScholarPubMed
Wick, MR, Scheithauer, BW, Dines, DE. Thymic neoplasia in two male siblings. Mayo Clin Proc. 1982;57:653–6.Google ScholarPubMed
Pascuzzi, RM, Sermas, A, Phillips, LH et al. Familial autoimmune myasthenia gravis and thymoma: occurrence in two brothers. Neurology. 1986;36:423–7.CrossRefGoogle ScholarPubMed
Walter, E, Wilich, E, Webb, WR. The Thymus: Diagnostic Imaging, Functions and Pathologic Anatomy (Medical Radiology/Diagnostic Imaging). 2012; New York: Springer.Google Scholar
Heitzman, ER. The Mediastinum: Radiologic Correlations with Pathology. 2012; New York: Springer.Google Scholar
Hwang, JT, Kim, MH, Chang, KJ et al. A case of invasive thymoma with endotracheal polypoid growth. Tuberc Respir Dis (Seoul). 2012;73:331–5.CrossRefGoogle ScholarPubMed
Lavini, C, Moran, CA, Morandi, U et al. Thymus Gland Pathology: Clinical, Diagnostic and Therapeutic. 2008; New York: Springer.CrossRefGoogle Scholar
Lewis, JE, Wick, MR, Scheithauer, BW et al. Thymoma. A clinicopathologic review. Cancer. 1987;60:2727–43.3.0.CO;2-D>CrossRefGoogle ScholarPubMed
Kurata, A, Saji, H, Ikeda, N et al. Intracaval and intracardiac extension of invasive thymoma complicated by superior and inferior vena cava syndrome. Pathol Int. 2013;63:56–62.CrossRefGoogle ScholarPubMed
Yalcin, B, Demir, HA, Ciftci, AO et al. Thymomas in childhood: 11 cases from a single institution. J Pediatr Hematol Oncol. 2012;34:601–5.CrossRefGoogle ScholarPubMed
Toker, A, Tireli, E, Tanju, S et al. Transcaval invasion of right atrium by thymoma: resection via transient cava-pulmonary shunt. Eur J Cardiothorac Surg. 2012;41:1175–7.CrossRefGoogle ScholarPubMed
Rosa, GR, Takizawa, N, Schimidt, D et al. Surgical treatment of superior vena cava syndrome caused by invasive thymoma. Rev Bras Cir Cardiovasc. 2010;25:257–60.CrossRefGoogle ScholarPubMed
Tormoehlen, LM, Pascuzzi, RM. Thymoma, myasthenia gravis, and other paraneoplastic syndromes. Hematol Oncol Clin North Am. 2008;22:509–26.CrossRefGoogle ScholarPubMed
Weigert, C. Pathogisch-Anatomischer Beirtrag zur Erbschen Krankhei. Neurol Zentralbl. 1901;597.Google Scholar
Strobel, P, Preisshofen, T, Helmreich, M et al. Pathomechanisms of paraneoplastic myasthenia gravis. Clin Dev Immunol. 2003;10:7–12.CrossRefGoogle ScholarPubMed
Strobel, P, Helmreich, M, Menioudakis, G et al. Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4(+) T cells in thymomas. Blood. 2002;100:159–66.CrossRefGoogle ScholarPubMed
Spuler, S, Sarropoulos, A, Marx, A et al. Thymoma-associated myasthenia gravis. Transplantation of thymoma and extrathymomal thymic tissue into SCID mice. Am J Pathol. 1996;148:1359–65.Google ScholarPubMed
Muller-Hermelink, HK, Marx, A, Geuder, K et al. The pathological basis of thymoma-associated myasthenia gravis. Ann N Y Acad Sci. 1993;681:56–65.CrossRefGoogle ScholarPubMed
Mao, ZF, Mo, XA, Qin, C et al. Incidence of thymoma in myasthenia gravis: a systematic review. J Clin Neurol. 2012;8:161–9.CrossRefGoogle ScholarPubMed
Piccolo, G, Martino, G, Moglia, A et al. Autoimmune myasthenia gravis with thymoma following the spontaneous remission of stiff-man syndrome. Ital J Neurol Sci. 1990;11:177–80.CrossRefGoogle ScholarPubMed
de Castro, MA, de Castro, MA, Arantes, AM et al. Thymoma followed by aplastic anemia – two different responses to immunosuppressive therapy. Rev Bras Hematol Hemoter. 2011;33:476–7.CrossRefGoogle ScholarPubMed
Bajel, A, Ryan, A, Roy, S et al. Aplastic anaemia: autoimmune sequel of thymoma. Br J Haematol. 2009;147:591.CrossRefGoogle ScholarPubMed
Gaglia, A, Bobota, A, Pectasides, E et al. Successful treatment with cyclosporine of thymoma-related aplastic anemia. Anticancer Res. 2007;27:3025–8.Google ScholarPubMed
Coplu, L, Selcuk, ZT, Haznedaroglu, IC et al. Aplastic pancytopenia associated with thymoma. Ann Hematol. 2000;79:648–50.Google ScholarPubMed
van SA, Wirtz, PW, Verschuuren, JJ et al. Paraneoplastic syndromes of the neuromuscular junction: therapeutic options in myasthenia gravis, lambert-eaton myasthenic syndrome, and neuromyotonia. Curr Treat Options Neurol. 2013;15:224–39.Google Scholar
Kon, T, Mori, F, Tanji, K et al. Giant cell polymyositis and myocarditis associated with myasthenia gravis and thymoma. Neuropathology. 2013 Jun;33(3):281–7. . E-pub 2012 Sep 19.CrossRefGoogle ScholarPubMed
Miyazaki, Y, Hirayama, M, Watanabe, H et al. Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma. J Clin Neurosci. 2012;19:336–8.CrossRefGoogle ScholarPubMed
Silvestri, NJ, Wolfe, GI. Myasthenia gravis. Semin Neurol. 2012;32:215–26.CrossRefGoogle ScholarPubMed
Wilkins, EW, Castleman, B. Thymoma: a continuing survey at the Massachusetts General Hospital. Ann Thorac Surg. 1979;28:252–6.CrossRefGoogle ScholarPubMed
az-Manera, J, Rojas, GR, Illa, I. Treatment strategies for myasthenia gravis: an update. Expert Opin Pharmacother. 2012;13:1873–83.CrossRefGoogle Scholar
Spaggiari, L, Casiraghi, M, Guarize, J. Multidisciplinary treatment of malignant thymoma. Curr Opin Oncol. 2012;24:117–22.CrossRefGoogle ScholarPubMed
Maclennan, CA, Vincent, A, Marx, A et al. Preferential expression of AChR epsilon-subunit in thymomas from patients with myasthenia gravis. J Neuroimmunol. 2008;201–2:28–32.CrossRefGoogle ScholarPubMed
Gattenlohner, S, Brabletz, T, Schultz, A et al. Cloning of a cDNA coding for the acetylcholine receptor alpha-subunit from a thymoma associated with myasthenia gravis. Thymus. 1994;23:103–13.Google Scholar
Siara, J, Rudel, R, Marx, A. Absence of acetylcholine-induced current in epithelial cells from thymus glands and thymomas of myasthenia gravis patients. Neurology. 1991;41:128–31.CrossRefGoogle ScholarPubMed
Marx, A, O’Connor, R, Geuder, KI et al. Characterization of a protein with an acetylcholine receptor epitope from myasthenia gravis-associated thymomas. Lab Invest. 1990;62:279–86.Google ScholarPubMed
Geuder, KI, Schoepfer, R, Kirchner, T et al. The gene of the alpha-subunit of the acetylcholine receptor: molecular organisation and transcription in myasthenia-associated thymomas. Thymus. 1989;14:179–86.Google ScholarPubMed
Marx, A, O’Connor, R, Tzartos, S et al. Acetylcholine receptor epitope in proteins of myasthenia gravis-associated thymomas and non-thymic tissues. Thymus. 1989;14:171–8.Google ScholarPubMed
Wilisch, A, Gutsche, S, Hoffacker, V et al. Association of acetylcholine receptor alpha-subunit gene expression in mixed thymoma with myasthenia gravis. Neurology. 1999;52:1460–6.CrossRefGoogle ScholarPubMed
Marx, A, Wilisch, A, Schultz, A et al. Pathogenesis of myasthenia gravis. Virchows Arch. 1997;430:355–64.CrossRefGoogle ScholarPubMed
Judd, RL, Welch, SL. Myoid cell differentiation in true thymic hyperplasia and lymphoid hyperplasia. Arch Pathol Lab Med. 1988;112:1140–4.Google ScholarPubMed
Hayward, AR. Myoid cells in the human foetal thymus. J Pathol. 1972;106:45–8.CrossRefGoogle ScholarPubMed
Hayward, A. The detection of myoid cells in the human foetal and neonatal thymus by immunofluorescence.J Med Microbiol. 1970;3:v.Google ScholarPubMed
Ito, T, Hoshino, T, Abe, K. The fine structure of myoid cells in the human thymus. Arch Histol Jpn. 1969;30:207–15.CrossRefGoogle ScholarPubMed
Marx, A, Pfister, F, Schalke, B et al. The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes. Autoimmun Rev. 2013.
Kirchner, T, Tzartos, S, Hoppe, F et al. Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors. Am J Pathol. 1988;130:268–80.Google ScholarPubMed
Yang, H, Hao, J, Peng, X et al. The association of HLA-DQA1*0401 and DQB1*0604 with thymomatous myasthenia gravis in northern Chinese patients. J Neurol Sci. 2012;312:57–61.CrossRefGoogle ScholarPubMed
Kont, V, Murumagi, A, Tykocinski, LO et al. DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues. Mol Immunol. 2011;49:518–26.CrossRefGoogle ScholarPubMed
Deitiker, PR, Oshima, M, Smith, RG et al. Association with HLA DQ of early onset myasthenia gravis in Southeast Texas region of the United States. Int J Immunogenet. 2011;38:55–62.CrossRefGoogle ScholarPubMed
Vandiedonck, C, Raffoux, C, Eymard, B et al. Association of HLA-A in autoimmune myasthenia gravis with thymoma. J Neuroimmunol. 2009;210:120–23.CrossRefGoogle ScholarPubMed
Santos, SG, Antoniou, AN, Sampaio, P et al. Lack of tyrosine 320 impairs spontaneous endocytosis and enhances release of HLA-B27 molecules. J Immunol. 2006;176:2942–9.CrossRefGoogle ScholarPubMed
Donmez, B, Ozakbas, S, Oktem, MA et al. HLA genotypes in Turkish patients with myasthenia gravis: comparison with multiple sclerosis patients on the basis of clinical subtypes and demographic features. Hum Immunol. 2004;65:752–7.CrossRefGoogle ScholarPubMed
Antoniou, AN, Ford, S, Taurog, JD et al. Formation of HLA-B27 homodimers and their relationship to assembly kinetics. J Biol Chem. 2004;279:8895–902.CrossRefGoogle ScholarPubMed
Garcia-Ramos, G, Tellez-Zenteno, JF, Zapata-Zuniga, M et al. HLA class II genotypes in Mexican Mestizo patients with myasthenia gravis. Eur J Neurol. 2003;10:707–10.CrossRefGoogle ScholarPubMed
Machens, A, Loliger, C, Pichlmeier, U et al. Correlation of thymic pathology with HLA in myasthenia gravis. Clin Immunol. 1999;91:296–301.CrossRefGoogle ScholarPubMed
Vieira, ML, Caillat-Zucman, S, Gajdos, P et al. Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis. J Neuroimmunol. 1993;47:115–22.CrossRefGoogle ScholarPubMed
Zisimopoulou, P, Brenner, T, Trakas, N et al. Serological diagnostics in myasthenia gravis based on novel assays and recently identified antigens. Autoimmun Rev. 2013; 12:924–30.CrossRefGoogle ScholarPubMed
Aysal, F, Baybas, S, Selcuk, HH et al. Paraneoplastic extralimbic encephalitis associated with thymoma and myasthenia gravis: Three years follow up. Clin Neurol Neurosurg. 2013;115:628–31.CrossRefGoogle ScholarPubMed
Beard, ME, Krantz, SB, Johnson, SA et al. Pure red cell aplasia. Q J Med. 1978;47:339–48.Google ScholarPubMed
Korn, D, Gelderman, A, Cage, G et al. Immune deficiencies, aplastic anemia and abnormalities of lymphoid tissue in thymoma. N Engl J Med. 1967;276:1333–9.CrossRefGoogle ScholarPubMed
Shibata, K, Masaoka, A, Mizuno, T et al. Pure red cell aplasia following irradiation of an asymptomatic thymoma. Jpn J Surg. 1982;12:419–23.CrossRefGoogle ScholarPubMed
Saha, M, Ray, S, Kundu, S et al. Pure red cell aplasia following autoimmune hemolytic anemia: An enigma. J Postgrad Med. 2013;59:51–3.Google Scholar
Balikar, R, Redkar, NN, Patil, MA et al. Myasthenia gravis and pure red cell aplasia: a rare association. BMJ Case Rep. 2013. .
Baral, A, Poudel, B, Agrawal, RK et al. Pure red cell aplasia caused by Parvo B19 virus in a kidney transplant recipient. JNMA J Nepal Med Assoc. 2012;52:75–8.Google Scholar
Sreenivasan, P, Mani, NS. Pure red cell aplasia in systemic onset juvenile idiopathic arthritis. Indian J Hematol Blood Transfus. 2012;28:42–3.CrossRefGoogle ScholarPubMed
Masaoka, A, Hashimoto, T, Shibata, K et al. Thymomas associated with pure red cell aplasia. Histologic and follow-up studies. Cancer. 1989;64:1872–8.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Voigt, S. Polycytaemia vera associated with thymoma. Case report. Acta Pathol Microbiol Immunol Scand A. 1986;94:351–2.Google ScholarPubMed
Ertel, V, Fruh, M, Guenther, A et al. Thymoma with molecularly verified “conversion” into T lymphoblastic leukemia/lymphoma over nine years. Leuk Lymphoma. 2013.
Sichere, P, Galimard, E, Fromaget, M et al. Myeloma and thymoma: an as yet unreported association. Rev Rhum Engl Ed. 1997;64:518–19.Google Scholar
Weir, AB, Dow, LW. Response of agranulocytosis to thymectomy in a patient with thymoma and chronic lymphocytic leukemia. Med Pediatr Oncol. 1989;17:58–61.CrossRefGoogle Scholar
Davila, DG, Ryan, DH. Thymoma, hypogammaglobulinemia, and pernicious anemia. South Med J. 1986;79:904–6.CrossRefGoogle ScholarPubMed
Lyonnais, J. Thymoma and pancytopenia. Am J Hematol. 1988;28:195–6.CrossRefGoogle ScholarPubMed
Fitzmaurice, RJ, Gardner, DL. Thymoma with bone marrow eosinophilia. J R Soc Med. 1990;83:270–1.CrossRefGoogle ScholarPubMed
Kikuchi, R, Mino, N, Okamoto, T et al. A case of Good’s syndrome: a rare acquired immunodeficiency associated with thymoma. Ann Thorac Cardiovasc Surg. 2011;17:74–6.CrossRefGoogle ScholarPubMed
Waldmann, TA, Broder, S, Durm, M et al. Suppressor T cells in the pathogenesis of hypogammaglobulinemia associated with a thymoma. Trans Assoc Am Physicians. 1975;88:120–34.Google ScholarPubMed
Habbe, N, Waldmann, J, Bartsch, DK et al. Multimodal treatment of sporadic and inherited neuroendocrine tumors of the thymus. Surgery. 2008;144:780–5.CrossRefGoogle ScholarPubMed
Montes, LF, Ceballos, R, Cooper, MD et al. Chronic mucocutaneous candidiasis, myositis, and thymoma. A new triad. JAMA. 1972;222:1619–23.CrossRefGoogle ScholarPubMed
Kauffman, CA, Linnemann, CC, Alvira, MM. Cytomegalovirus encephalitis associated with thymoma and immunoglobulin deficiency. Am J Med. 1979;67:724–8.CrossRefGoogle ScholarPubMed
Kisand, K, Lilic, D, Casanova, JL, et al. Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications. Eur J Immunol 2011;41(6):1517–727.CrossRefGoogle ScholarPubMed
Chen, PC, Pan, CC, Yang, AH et al. Detection of Epstein-Barr virus genome within thymic epithelial tumours in Taiwanese patients by nested PCR, PCR in situ hybridization, and RNA in situ hybridization. J Pathol. 2002;197:684–8.CrossRefGoogle ScholarPubMed
Borisch, B, Kirchner, T, Marx, A et al. Absence of the Epstein-Barr virus genome in the normal thymus, thymic epithelial tumors, thymic lymphoid hyperplasia in a European population. Virchows Arch B Cell Pathol Incl Mol Pathol. 1990;59:359–65.CrossRefGoogle Scholar
Inghirami, G, Chilosi, M, Knowles, DM. Western thymomas lack Epstein-Barr virus by Southern blotting analysis and by polymerase chain reaction. Am J Pathol. 1990;136:1429–36.Google ScholarPubMed
McGuire, LJ, Huang, DP, Teoh, R et al. Epstein-Barr virus genome in thymoma and thymic lymphoid hyperplasia. Am J Pathol. 1988;131:385–90.Google ScholarPubMed
Yoshida, M, Miyoshi, T, Sakiyama, S et al. Pemphigus with thymoma improved by thymectomy: report of a case. Surg Today. 2012; 20:479–81.Google Scholar
Rota, C, Lupi, F, De, PO et al. Pemphigus foliaceous with thymoma and multiple comorbidities: a fatal case. Eur J Dermatol. 2011;21:424–5.Google ScholarPubMed
Barbetakis, N, Samanidis, G, Paliouras, D et al. Paraneoplastic pemphigus regression after thymoma resection. World J Surg Oncol. 2008;6:83.CrossRefGoogle ScholarPubMed
Winkler, DT, Strnad, P, Meier, ML et al. Myasthenia gravis, paraneoplastic pemphigus and thymoma, a rare triade. J Neurol. 2007;254:1601–3.CrossRefGoogle ScholarPubMed
Gibson, LE, Muller, SA. Dermatologic disorders in patients with thymoma. Acta Derm Venereol. 1987;67:351–6.Google ScholarPubMed
Holbro, A, Jauch, A, Lardinois, D et al. High prevalence of infections and autoimmunity in patients with thymoma. Hum Immunol. 2012;73:287–90.CrossRefGoogle ScholarPubMed
Shelly, S, gmon-Levin, N, Altman, A et al. Thymoma and autoimmunity. Cell Mol Immunol. 2011;8:199–202.CrossRefGoogle ScholarPubMed
Sherer, Y, Bardayan, Y, Shoenfeld, Y. Thymoma, thymic hyperplasia, thymectomy and autoimmune diseases (Review). Int J Oncol. 1997;10:939–43.Google Scholar
Yapali, S, Oruc, N, Ilgun, S et al. Acute presentation of autoimmune hepatitis in a patient with myasthenia gravis, thymoma, Hashimoto thyroiditis and connective tissue disorder. Hepatol Res. 2012;42:835–39.CrossRefGoogle Scholar
Karras, A, de Montpreville, V, Fakhouri, F et al. Renal and thymic pathology in thymoma-associated nephropathy: report of 21 cases and review of the literature. Nephrol Dial Transplant. 2005;20:1075–82.CrossRefGoogle ScholarPubMed
Varsano, S, Bruderman, I, Bernheim, JL et al. Minimal-change nephropathy and malignant thymoma. Chest. 1980;77:695–7.CrossRefGoogle ScholarPubMed
Skinnider, LF, Alexander, S, Horsman, D. Concurrent thymoma and lymphoma: a report of two cases. Hum Pathol. 1982;13:163–6.CrossRefGoogle ScholarPubMed
Ridell, B, Larsson, S. Coexistence of a thymoma and Hodgkin’s disease of the thymus. A case report. Acta Pathol Microbiol Scand A. 1980;88:1–4.Google ScholarPubMed
Souadjian, JV, Silverstein, MN, Titus, JL. Thymoma and cancer. Cancer. 1968;22:1221–5.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Lesser, M, Mouli, CC, Jothikumar, T. Hypertrophic osteoarthropathy associated with a malignant thymoma. Mt Sinai J Med. 1980;47:24–30.Google ScholarPubMed
Palmer, FJ, Sawyers, TM. Hyperparathyroidism, chemodectoma, thymoma, and myasthenia gravis. Arch Intern Med. 1978;138:1402–3.CrossRefGoogle ScholarPubMed
Vincent, A, Waters, P, Leite, MI et al. Antibodies identified by cell-based assays in myasthenia gravis and associated diseases. Ann N Y Acad Sci. 2012;1274:92–8.CrossRefGoogle ScholarPubMed
Vernino, S, Lennon, VA. Autoantibody profiles and neurological correlations of thymoma. Clin Cancer Res. 2004;10:7270–5.CrossRefGoogle ScholarPubMed
Smith, WF, DeWall, RA, Krumholz, RA. Giant thymoma. Chest. 1970;58:383–4.CrossRefGoogle ScholarPubMed
Rieker, RJ, Aulmann, S, Schnabel, PA et al. Cystic thymoma. Pathol Oncol Res. 2005;11:57–60.CrossRefGoogle ScholarPubMed
Moran, CA, Suster, S. Thymoma with prominent cystic and hemorrhagic changes and areas of necrosis and infarction: a clinicopathologic study of 25 cases. Am J Surg Pathol. 2001;25:1086–90.CrossRefGoogle ScholarPubMed
Effler, DB, McCormack, LJ. Thymic neoplasms. J Thorac Surg. 1956;31:60–77.Google ScholarPubMed
Bernatz, PE, Harrison, EG, Clagett, OT. Thymoma: a clinicopathologic study. J Thorac Cardiovasc Surg. 1961;42:424–44.Google ScholarPubMed
Snover, DC, Levine, GD, Rosai, J. Thymic carcinoma. Five distinctive histological variants. Am J Surg Pathol. 1982;6:451–70.CrossRefGoogle ScholarPubMed
Muller-Hermelink, HK, Marino, M, Palestro, G. Pathology of thymic epithelial tumors. Curr Top Pathol. 1986;75:207–68.CrossRefGoogle ScholarPubMed
Muller-Hermelink, HK, Marx, A. Towards a histogenetic classification of thymic epithelial tumours?Histopathology. 2000;36:466–9.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA. Thymoma classification. The ride of the valkyries?Am J Clin Pathol. 1999;112:308–10.CrossRefGoogle ScholarPubMed
Dadmanesh, F, Sekihara, T, Rosai, J. Histologic typing of thymoma according to the new World Health Organization classification. Chest Surg Clin N Am. 2001;11:407–20.Google ScholarPubMed
Chalabreysse, L, Roy, P, Cordier, JF et al. Correlation of the WHO schema for the classification of thymic epithelial neoplasms with prognosis: a retrospective study of 90 tumors. Am J Surg Pathol. 2002;26:1605–11.CrossRefGoogle ScholarPubMed
Chen, G, Marx, A, Chen, WH et al. New WHO histologic classification predicts prognosis of thymic epithelial tumors: a clinicopathologic study of 200 thymoma cases from China. Cancer. 2002;95:420–9.CrossRefGoogle ScholarPubMed
Detterbeck, FC. Clinical value of the WHO classification system of thymoma. Ann Thorac Surg. 2006;81:2328–34.CrossRefGoogle ScholarPubMed
Kondo, K, Yoshizawa, K, Tsuyuguchi, M et al. WHO histologic classification is a prognostic indicator in thymoma. Ann Thorac Surg. 2004;77:1183–8.CrossRefGoogle ScholarPubMed
Okumura, M, Ohta, M, Miyoshi, S et al. Oncological significance of WHO histological thymoma classification. A clinical study based on 286 patients. Jpn J Thorac Cardiovasc Surg. 2002;50:189–94.CrossRefGoogle ScholarPubMed
Okumura, M, Miyoshi, S, Fujii, Y et al. Clinical and functional significance of WHO classification on human thymic epithelial neoplasms: a study of 146 consecutive tumors. Am J Surg Pathol. 2001;25:103–10.CrossRefGoogle ScholarPubMed
Sonobe, S, Miyamoto, H, Izumi, H et al. Clinical usefulness of the WHO histological classification of thymoma. Ann Thorac Cardiovasc Surg. 2005;11:367–73.Google ScholarPubMed
Moran, CA, Suster, S. The World Health Organization (WHO) histologic classification of thymomas: a reanalysis. Curr Treat Options Oncol. 2008;9:288–99.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA. Thymoma, atypical thymoma, and thymic carcinoma. A novel conceptual approach to the classification of thymic epithelial neoplasms. Am J Clin Pathol. 1999;111:826–33.CrossRefGoogle ScholarPubMed
Moran, CA, Weissferdt, A, Kalhor, N et al. Thymomas I: a clinicopathologic correlation of 250 cases with emphasis on the World Health Organization schema. Am J Clin Pathol. 2012;137:444–50.CrossRefGoogle ScholarPubMed
Moran, CA, Suster, S. Thymic epithelial neoplasms: a comprehensive review of diagnosis and treatment. Preface. Hematol Oncol Clin North Am. 2008;22:xi–xii.CrossRefGoogle ScholarPubMed
Marchevsky, AM, Wick, MR. Evidence-Based Pathology and Laboratory Medicine. 2011; New York: Springer.CrossRefGoogle Scholar
Marchevsky, AM, Gupta, R, Casadio, C et al. World Health Organization classification of thymomas provides significant prognostic information for selected stage III patients: evidence from an international thymoma study group. Hum Pathol. 2010;41:1413–21.CrossRefGoogle ScholarPubMed
Marchevsky, AM, Gupta, R, McKenna, RJ et al. Evidence-based pathology and the pathologic evaluation of thymomas: the World Health Organization classification can be simplified into only 3 categories other than thymic carcinoma. Cancer. 2008;112:2780–8.CrossRefGoogle ScholarPubMed
Detterbeck, FC, Nicholson, AG, Kondo, K et al. The Masaoka-Koga stage classification for thymic malignancies: clarification and definition of terms. J Thorac Oncol. 2011;6:S1710–S1716.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA. Spindle cell thymic carcinoma: clinicopathologic and immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm. Am J Surg Pathol. 1999;23:691–700.CrossRefGoogle ScholarPubMed
Weissferdt, A, Hernandez, JC, Kalhor, N et al. Spindle cell thymomas: an immunohistochemical study of 30 cases. Appl Immunohistochem Mol Morphol. 2011;19:329–35.CrossRefGoogle ScholarPubMed
Eimoto, T, Teshima, K, Shirakusa, T et al. Heterogeneity of epithelial cells and reactive components in thymomas: an ultrastructural and immunohistochemical study. Ultrastruct Pathol. 1986;10:157–73.CrossRefGoogle ScholarPubMed
Weissferdt, A, Moran, CA. Pax8 expression in thymic epithelial neoplasms: an immunohistochemical analysis. Am J Surg Pathol. 2011;35:1305–10.CrossRefGoogle ScholarPubMed
Cornea, R, Cimpean, AM, Simu, M et al. Clinical, morphological and immunohistochemical characterization of a recurrent B1 type thymoma. Rom J Morphol Embryol. 2012;53:639–43.Google ScholarPubMed
Chu, PG, Weiss, LM. Expression of cytokeratin 5/6 in epithelial neoplasms: an immunohistochemical study of 509 cases. Mod Pathol. 2002;15:6–10.CrossRefGoogle ScholarPubMed
Cimpean, AM, Raica, M, Encica, S. Overexpression of cytokeratin 34beta E12 in thymoma: could it be a poor prognosis factor?Rom J Morphol Embryol. 1999;45:153–7.Google ScholarPubMed
Kojika, M, Ishii, G, Yoshida, J et al. Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms. Mod Pathol. 2009;22:1341–50.CrossRefGoogle ScholarPubMed
Shiraishi, J, Nomori, H, Orikasa, H et al. Atypical thymoma (WHO B3) with neuroendocrine differentiation: report of a case. Virchows Arch. 2006;449:234–7.CrossRefGoogle ScholarPubMed
Giaccone, G, Rajan, A, Ruijter, R et al. Imatinib mesylate in patients with WHO B3 thymomas and thymic carcinomas. J Thorac Oncol. 2009;4:1270–3.CrossRefGoogle ScholarPubMed
Kaira, K, Murakami, H, Serizawa, M et al. MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. Virchows Arch. 2011;458:615–20.CrossRefGoogle ScholarPubMed
Khoury, T, Chandrasekhar, R, Wilding, G et al. Tumour eosinophilia combined with an immunohistochemistry panel is useful in the differentiation of type B3 thymoma from thymic carcinoma. Int J Exp Pathol. 2011;92:87–96.CrossRefGoogle ScholarPubMed
Kojika, M, Ishii, G, Yoshida, J et al. Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms. Mod Pathol. 2009;22:1341–50.CrossRefGoogle ScholarPubMed
Laeng, RH, Eimoto, T, Kuo, TT et al. Corpuscular thymoma: entity or variant of organotypical thymomas WHO B2/B3?Pathol Res Pract. 2006;202:697–704.CrossRefGoogle ScholarPubMed
Shiraishi, J, Nomori, H, Orikasa, H et al. Atypical thymoma (WHO B3) with neuroendocrine differentiation: report of a case. Virchows Arch. 2006;449:234–7.CrossRefGoogle ScholarPubMed
Yoshino, N, Kubokura, H, Yamauchi, S et al. Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. Ann Thorac Cardiovasc Surg. 2009;15:324–7.Google Scholar
Verghese, ET, den Bakker, MA, Campbell, A et al. Interobserver variation in the classification of thymic tumours–a multicentre study using the WHO classification system. Histopathology. 2008;53:218–23.CrossRefGoogle ScholarPubMed
Rieker, RJ, Muley, T, Klein, C et al. An institutional study on thymomas and thymic carcinomas: experience in 77 patients. Thorac Cardiovasc Surg. 2008;56:143–7.CrossRefGoogle ScholarPubMed
Kendall, MD. The morphology of perivascular spaces in the thymus. Thymus. 1989;13:157–64.Google ScholarPubMed
Nonaka, D, Rosai, J. Is there a spectrum of cytologic atypia in type A thymomas analogous to that seen in type B thymomas? A pilot study of 13 cases. Am J Surg Pathol 2012;36:889–94.CrossRefGoogle Scholar
Vladislav, IT, Gokmen-Polar, Y, Kesler, KA, et al. The role of histology in predicting recurrence of type A thymomas: a clinicopathologic correlation of 23 cases. Mod Pathol 2013 Aug; 26(8):1059–64.CrossRefGoogle ScholarPubMed
Kirchner, T, Schalke, B, Buchwald, J et al. Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. Am J Surg Pathol. 1992;16:1153–69.CrossRefGoogle ScholarPubMed
Nobre, AR, Albergaria, A, Schmitt F. p40: a p63 isoform useful for lung cancer diagnosis – a review of the physiological and pathological role of p63. Acta Cytol. 2013;57:1–8.CrossRefGoogle ScholarPubMed
Moran, CA, Suster, S. On the histologic heterogeneity of thymic epithelial neoplasms. Impact of sampling in subtyping and classification of thymomas. Am J Clin Pathol. 2000;114:760–6.CrossRefGoogle ScholarPubMed
Moran, CA, Walsh, G, Suster, S et al. Thymomas II: a clinicopathologic correlation of 250 cases with a proposed staging system with emphasis on pathologic assessment. Am J Clin Pathol. 2012;137:451–61.CrossRefGoogle ScholarPubMed
Detterbeck, FC, Moran, C, Huang, J et al. Which way is up? Policies and procedures for surgeons and pathologists regarding resection specimens of thymic malignancy. J Thorac Oncol. 2011;6:S1730–S1738.CrossRefGoogle ScholarPubMed
Marchevsky, A, Marx, A, Strobel, P et al. Policies and reporting guidelines for small biopsy specimens of mediastinal masses. J Thorac Oncol. 2011;6:S1724–S1729.CrossRefGoogle ScholarPubMed
Cho, KJ, Ha, CW, Koh, JS et al. Thymic carcinoid tumor combined with thymoma–neuroendocrine differentiation in thymoma?J Korean Med Sci. 1993;8:458–63.CrossRefGoogle ScholarPubMed
Steger, C, Steiner, HJ, Moser, K et al. A typical thymic carcinoid tumour within a thymolipoma: report of a case and review of combined tumours of the thymus. BMJ Case Rep. 2010. .
Suster, S, Moran, CA. Primary thymic epithelial neoplasms showing combined features of thymoma and thymic carcinoma. A clinicopathologic study of 22 cases. Am J Surg Pathol. 1996;20:1469–80.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA, Chan, JK. Thymoma with pseudosarcomatous stroma: report of an unusual histologic variant of thymic epithelial neoplasm that may simulate carcinosarcoma. Am J Surg Pathol. 1997;21:1316–23.CrossRefGoogle ScholarPubMed
Kang, G, Yoon, N, Han, J et al. Metaplastic thymoma: report of 4 cases. Korean J Pathol. 2012;46:92–5.CrossRefGoogle ScholarPubMed
Liu, B, Rao, Q, Zhu, Y et al. Metaplastic thymoma of the mediastinum. A clinicopathologic, immunohistochemical, and genetic analysis. Am J Clin Pathol. 2012;137:261–9.CrossRefGoogle ScholarPubMed
Lu, HS, Gan, MF, Zhou, T et al. Sarcomatoid thymic carcinoma arising in metaplastic thymoma: a case report. Int J Surg Pathol. 2011;19:677–80.CrossRefGoogle ScholarPubMed
Moritani, S, Ichihara, S, Mukai, K et al. Sarcomatoid carcinoma of the thymus arising in metaplastic thymoma. Histopathology. 2008;52:409–11.CrossRefGoogle ScholarPubMed
Poorabdollah, M, Mehdizadeh, E, Mohammadi, F et al. Metaplastic thymoma: report of an unusual thymic epithelial neoplasm arising in the wall of a thymic cyst. Int J Surg Pathol. 2009;17:51–4.CrossRefGoogle ScholarPubMed
Yoneda, S, Marx, A, Muller-Hermelink, HK. Low-grade metaplastic carcinomas of the thymus: biphasic thymic epithelial tumors with mesenchymal metaplasia–an update. Pathol Res Pract. 1999;195:555–63.CrossRefGoogle ScholarPubMed
Strobel, P, Marino, M, Feuchtenberger, M et al. Micronodular thymoma: an epithelial tumour with abnormal chemokine expression setting the stage for lymphoma development. J Pathol. 2005;207:72–82.CrossRefGoogle ScholarPubMed
Suster, S, Moran, CA. Micronodular thymoma with lymphoid B-cell hyperplasia: clinicopathologic and immunohistochemical study of eighteen cases of a distinctive morphologic variant of thymic epithelial neoplasm. Am J Surg Pathol. 1999;23:955–62.CrossRefGoogle ScholarPubMed
El, MF, Braham, E, Ayadi, A et al. Micronodular thymoma with lymphoid stroma: report of two cases and particular association with thymic lymphoid hyperplasia in one case. Pathology. 2006;38:586–8.Google ScholarPubMed
Mende, S, Moschopulos, M, Marx, A et al. Ectopic micronodular thymoma with lymphoid stroma. Virchows Arch. 2004;444:397–9.CrossRefGoogle ScholarPubMed
Moran, CA, Koss, MN. Rhabdomyomatous thymoma. Am J Surg Pathol. 1993;17:633–6.CrossRefGoogle ScholarPubMed
de Queiroga, EM, Chikota, H, Bacchi, CE et al. Rhabdomyomatous carcinoma of the thymus. Am J Surg Pathol. 2004;28:1245–50.Google ScholarPubMed
Salih, DM, Ceyhan, K, Deveci, G et al. Pericardial rhabdomyomatous spindle cell thymoma with mucinous cystic degeneration. Histopathology. 2001;38:479–81.CrossRefGoogle Scholar
Moran, CA, Suster, S. “Ancient” (sclerosing) thymomas: a clinicopathologic study of 10 cases. Am J Clin Pathol. 2004;121:867–71.CrossRefGoogle ScholarPubMed
Kuo, T. Sclerosing thymoma–a possible phenomenon of regression. Histopathology. 1994;25:289–91.CrossRefGoogle Scholar
Weissferdt, A, Moran, CA. Thymomas with prominent glandular differentiation: a clinicopathologic and immunohistochemical study of 12 cases. Hum Pathol. 2013; 44:1612–16.CrossRefGoogle ScholarPubMed
Kalhor, N, Suster, S, Moran, CA. Spindle cell thymomas (WHO Type A) with prominent papillary and pseudopapillary features: a clinicopathologic and immunohistochemical study of 10 cases. Am J Surg Pathol. 2011;35:372–7.CrossRefGoogle ScholarPubMed
Onuki, T, Iguchi, K, Inagaki, M et al. [Lipofibroadenoma of the thymus]. Kyobu Geka. 2009;62:395–8.Google Scholar
Moran, CA, Suster, S, Gil, J et al. Morphometric analysis of germinal centers in nonthymomatous patients with myasthenia gravis. Arch Pathol Lab Med. 1990;114:689–91.Google ScholarPubMed
Sherer, Y, Bardayan, Y, Shoenfeld, Y. Thymoma, thymic hyperplasia, thymectomy and autoimmune diseases (Review). Int J Oncol. 1997;10:939–43.Google Scholar
Willcox, N, Schluep, M, Ritter, MA et al. Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial cell subset?Am J Pathol. 1987;127:447–60.Google ScholarPubMed
Hofmann, WJ, Moller, P, Otto, HF. Thymic hyperplasia. II. Lymphofollicular hyperplasia of the thymus. An immunohistologic study. Klin Wochenschr. 1987;65:53–60.CrossRefGoogle ScholarPubMed
Alpert, LI, Papatestas, A, Kark, A et al. A histologic reappraisal of the thymus in myasthenia gravis. A correlative study of thymic pathology and response to thymectomy. Arch Pathol. 1971;91:55–61.Google ScholarPubMed
Papatestas, AE, Alpert, LI, Osserman, KE et al. Studies in myasthenia gravis: effects of thymectomy. Results on 185 patients with nonthymomatous and thymomatous myasthenia gravis, 1941–1969. Am J Med. 1971;50:465–74.CrossRefGoogle ScholarPubMed
Pascoe, HR, Miner, MS. An ultrastructural study of nine thymomas. Cancer. 1976;37:317–26.3.0.CO;2-8>CrossRefGoogle ScholarPubMed
Pedraza, MA. Thymoma immunological and ultrastructural characterization. Cancer. 1977;39:1455–61.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Bloodworth, JM, Hiratsuka, H, Hickey, RC et al. Ultrastructure of the human thymus, thymic tumors, and myasthenia gravis. Pathol Annu. 1975;10:329–91.Google ScholarPubMed
Low, TL. Biochemical characterization of thymic hormones in thymoma tissues. Thymus. 1990;15:93–105.Google ScholarPubMed
Low, TL, Goldstein, AL. Thymic hormones: an overview. Methods Enzymol. 1985;116:213–19.CrossRefGoogle ScholarPubMed
Chollet, P, Plagne, R, Fonck, Y et al. Thymoma with hypersecretion of thymic hormone. Thymus. 1981;3:321–34.Google ScholarPubMed
Ranelletti, FO, Iacobelli, S, Carmignani, M et al. Glucocorticoid receptors and in vitro corticosensitivity in human thymoma. Cancer Res. 1980;40:2020–5.Google ScholarPubMed
Ranelletti, FO, Carmignani, M, Marchetti, P et al. Estrogen binding by neoplastic human thymus cytosol. Eur J Cancer. 1980;16:951–5.CrossRefGoogle ScholarPubMed
Davies, SE, Macartney, JC, Camplejohn, RS et al. DNA flow cytometry of thymomas. Histopathology. 1989;15:77–83.CrossRefGoogle ScholarPubMed
Kristoffersson, U, Heim, S, Mandahl, N et al. Multiple clonal chromosome aberrations in two thymomas. Cancer Genet Cytogenet. 1989;41:93–8.CrossRefGoogle ScholarPubMed
Abraham, KM, Levin, SD, Marth, JD et al. Thymic tumorigenesis induced by overexpression of p56lck. Proc Natl Acad Sci U S A. 1991;88:3977–81.CrossRefGoogle ScholarPubMed
Barthlott, T, Keller, MP, Krenger, W et al. A short primer on early molecular and cellular events in thymus organogenesis and replacement. Swiss Med Wkly. 2007;137 Suppl 155:9S–13S.Google Scholar
Girard, N. Chemotherapy and targeted agents for thymic malignancies. Expert Rev Anticancer Ther. 2012;12:685–95.CrossRefGoogle ScholarPubMed
Manley, NR. Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation. Semin Immunol. 2000;12:421–8.CrossRefGoogle ScholarPubMed
Sasaki, H, Ide, N, Fukai, I et al. Gene expression analysis of human thymoma correlates with tumor stage. Int J Cancer. 2002;101:342–7.CrossRefGoogle ScholarPubMed
Weissferdt, A, Wistuba, II, Moran, CA. Molecular aspects of thymic carcinoma. Lung Cancer. 2012;78:127–32.CrossRefGoogle ScholarPubMed
Girard, N. Thymic tumors: relevant molecular data in the clinic. J Thorac Oncol. 2010;5:S291–S295.CrossRefGoogle ScholarPubMed
Mentzer, SJ, Swanson, SJ, DeCamp, MM et al. Mediastinoscopy, thoracoscopy, and video-assisted thoracic surgery in the diagnosis and staging of lung cancer. Chest. 1997;112:239S–241S.CrossRefGoogle ScholarPubMed
Vilmann, P, Puri, R. The complete ‘‘medical’’ mediastinoscopy (EUS-FNA + EBUS-TBNA). Minerva Med. 2007;98:331–8.Google Scholar
Zakkar, M, Tan, C, Hunt, I. Is video mediastinoscopy a safer and more effective procedure than conventional mediastinoscopy?Interact Cardiovasc Thorac Surg. 2012;14:81–4.CrossRefGoogle ScholarPubMed
Girard, N, Shen, R, Guo, T et al. Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas. Clin Cancer Res. 2009;15:6790–9.CrossRefGoogle ScholarPubMed
Zakowski, MF, Huang, J, Bramlage, MP. The role of fine needle aspiration cytology in the diagnosis and management of thymic neoplasia. J Thorac Oncol. 2010;5:S281–S285.CrossRefGoogle ScholarPubMed
Bergh, NP, Gatzinsky, P, Larsson, S et al. Tumors of the thymus and thymic region: I. Clinicopathological studies on thymomas. Ann Thorac Surg. 1978;25:91–8.CrossRefGoogle ScholarPubMed
Masaoka, A. Staging system of thymoma. J Thorac Oncol. 2010;5:S304–S312.CrossRefGoogle ScholarPubMed
Gupta, R, Marchevsky, AM, McKenna, RJ et al. Evidence-based pathology and the pathologic evaluation of thymomas: transcapsular invasion is not a significant prognostic feature. Arch Pathol Lab Med. 2008;132:926–30.Google Scholar
Blumberg, D, Port, JL, Weksler, B et al. Thymoma: a multivariate analysis of factors predicting survival. Ann Thorac Surg. 1995;60:908–13.CrossRefGoogle ScholarPubMed
Koppitz, H, Rockstroh, JK, Schuller, H et al. State-of-the-art classification and multimodality treatment of malignant thymoma. Cancer Treat Rev. 2012;38:540–8.CrossRefGoogle ScholarPubMed
Lucchi, M, Mussi, A. Surgical treatment of recurrent thymomas. J Thorac Oncol. 2010;5:S348–S351.CrossRefGoogle ScholarPubMed
Detterbeck, FC. Evaluation and treatment of stage I and II thymoma. J Thorac Oncol. 2010;5:S318–S322.CrossRefGoogle Scholar
Eng, TY, Thomas, CR. Radiation therapy in the management of thymic tumors. Semin Thorac Cardiovasc Surg. 2005;17:32–40.CrossRefGoogle ScholarPubMed
Gomez, D, Komaki, R. Technical advances of radiation therapy for thymic malignancies. J Thorac Oncol. 2010;5:S336–S343.CrossRefGoogle ScholarPubMed
Mangi, AA, Wain, JC, Donahue, DM et al. Adjuvant radiation of stage III thymoma: is it necessary?Ann Thorac Surg. 2005;79:1834–9.CrossRefGoogle ScholarPubMed
Vasamiliette, J, Hohenberger, P, Schoenberg, S et al. Treatment monitoring with 18F-FDG PET in metastatic thymoma after 90Y-Dotatoc and selective internal radiation treatment (SIRT). Hell J Nucl Med. 2009;12:271–3.Google Scholar
Weksler, B, Shende, M, Nason, KS et al. The role of adjuvant radiation therapy for resected stage III thymoma: a population-based study. Ann Thorac Surg. 2012;93:1822–8.CrossRefGoogle ScholarPubMed
Chahinian, AP. Chemotherapy of thymomas and thymic carcinomas. Chest Surg Clin N Am. 2001;11:447–56.Google ScholarPubMed
Chahinian, AP, Holland, JF, Bhardwaj, S. Chemotherapy for malignant thymoma. Ann Intern Med. 1983;99:736.Google ScholarPubMed
Dosios, T, Nikou, GC, Toubanakis, C et al. Multimodality treatment of neuroendocrine tumors of the thymus. Thorac Cardiovasc Surg. 2005;53:305–9.CrossRefGoogle ScholarPubMed
Filosso, PL, Actis Dato, GM, Ruffini, E et al. Multidisciplinary treatment of advanced thymic neuroendocrine carcinoma (carcinoid): report of a successful case and review of the literature. J Thorac Cardiovasc Surg. 2004;127:1215–19.CrossRefGoogle ScholarPubMed
Loehrer, PJ, Wang, W, Johnson, DH et al. Octreotide alone or with prednisone in patients with advanced thymoma and thymic carcinoma: an Eastern Cooperative Oncology Group Phase II Trial. J Clin Oncol. 2004;22:293–9.CrossRefGoogle ScholarPubMed
Loehrer, PJ, Wick, MR. Thymic malignancies. Cancer Treat Res. 2001;105:277–302.CrossRefGoogle ScholarPubMed
Schmitt, J, Loehrer, PJ. The role of chemotherapy in advanced thymoma. J Thorac Oncol. 2010;5:S357–S360.CrossRefGoogle ScholarPubMed
Nikolic, DM, Nikolic, AV, Lavrnic, DV et al. Childhood-onset myasthenia gravis with thymoma. Pediatr Neurol. 2012;46:329–31.CrossRefGoogle ScholarPubMed
Iorio, R, Evoli, A, Lauriola, L et al. A B3 type-thymoma in a 7-year-old child with myasthenia gravis. J Thorac Oncol. 2012;7:937–8.CrossRefGoogle Scholar
Dehner, LP, Martin, SA, Sumner, HW. Thymus related tumors and tumor-like lesions in childhood with rapid clinical progression and death. Hum Pathol. 1977;8:53–66.CrossRefGoogle ScholarPubMed
Welch, KJ, Tapper, D, Vawter, GP. Surgical treatment of thymic cysts and neoplasms in children. J Pediatr Surg. 1979;14:691–8.CrossRefGoogle ScholarPubMed
Bowie, PR, Teixeira, OH, Carpenter, B. Malignant thymoma in a nine-year-old boy presenting with pleuropericardial effusion. J Thorac Cardiovasc Surg. 1979;77:777–81.Google Scholar

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