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Chapter 60 - Hepatitis B and C Virus Infections in Pregnancy

from Section 11 - Infectious Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Amira El-Messidi  and
Maged Peter Ghali
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

You are seeing a new patient in consultation for transfer of care to your high-risk obstetrics unit at a tertiary center. She is a 27-year-old primigravida at 14+3 weeks’ gestation with an incidentally positive surface antigen to the hepatitis B virus (HBsAg) on routine prenatal testing. A copy of the original laboratory report has been provided to you. Although detailed serological investigations were performed, results are not available. The patient is aware of the results. Referral to a hepatologist has also been instigated. The patient’s first-trimester sonogram and aneuploidy screen were unremarkable. She has no obstetric complaints.

Keywords

Hepatitis B virus infection, hepatitis C virus infection, pregnancyClinical manifestationsComorbiditiesPhysical examinationInvestigationsPrenatal screening, serology analysisInvasive diagnostic procedures, considerationsCounselingTreatment, tenofovir fumaratePerinatal risks, complications, maternal-fetal morbidity, adverse outcomeMother-to-child, perinatal transmissionAntepartum, intrapartum, postpartum managementObstetric deliveryPercutaneous exposure, hepatitis B infection
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 774 - 786
Publisher: Cambridge University Press
Print publication year: 2023

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References

Primary Sources

Castillo, E, Murphy, K, van Schalkwyk, J. No. 342 – hepatitis B and pregnancy. J Obstet Gynaecol Can. 2017 Mar;39(3):181–190.CrossRefGoogle ScholarPubMed
CDC guidance for evaluating health-care personnel for hepatitis B virus protection and for administering postexposure management. MMWR Recomm Reports 2013; 62(RR-10):1–19.Google Scholar
European Association for the Study of the Liver. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 2017 Aug;67(2):370–398.CrossRefGoogle Scholar
Gagnon, A, Davies, G, Wilson, RD. Genetics Committee. Prenatal invasive procedures in women with hepatitis B, hepatitis C, and/or human immunodeficiency virus infections. J Obstet Gynecol Can 2014;36: 648–653.Google Scholar
National Institute for Health and Care Excellence. Hepatitis B (chronic): diagnosis and management of chronic hepatitis B in children, young people and adults. Clinical guideline 165. 2013. Available at http://guidance.nice.org.uk/CG165. Accessed April 22, 2022.Google Scholar
Schillie, S, Vellozzi, C, Reingold, A, et al. Prevention of hepatitis B virus infection in the united States: recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2018 Jan 12;67(1):1–31.CrossRefGoogle ScholarPubMed
Society for Maternal-Fetal Medicine (SMFM), Dionne-Odom, J, Tita, AT, Silverman, NS. No. 38: Hepatitis B in pregnancy screening, treatment, and prevention of vertical transmission. Am J Obstet Gynecol. 2016 Jan;214(1):6–14.Google Scholar
Terrault, NA, Lok, ASF, McMahon, BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018 Apr;67(4):1560–1599.Google Scholar
World Health Organization. Prevention of mother-to-child transmission of hepatitis B virus: guidelines on antiviral prophylaxis in pregnancy, 2020 Jul. PMID: 32833415.Google Scholar

Secondary Sources

ACOG Practice Advisory: Routine hepatitis C virus screening in pregnant individuals. May 2021. Available at www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2021/05/routine-hepatitis-c-virus-screening-in-pregnant-individuals. Accessed October 26, 2021.Google Scholar
Havens, PL, Anderson, JR. Updated CDC recommendations for universal hepatitis C virus screening among adults and pregnant women: implications for clinical practice. JAMA. 2020 Jun 9;323(22):2258–2259.Google Scholar
Hepatitis C guidance: recommendations for testing, managing, and treating hepatitis C virus. American Association for the Study of Liver Diseases and the Infectious Diseases Society of America (AASLD-IDSA). Available at www.hcvguidelines.org/sites/default/files/full-guidance-pdf/AASLD-IDSA_HCVGuidance_January_21_2021.pdf. Accessed October 26, 2021.Google Scholar
Jhaveri, R, Broder, T, Bhattacharya, D, et al. Universal screening of pregnant women for hepatitis C: the time is now. Clin Infect Dis. 2018 Oct 30;67(10):1493–1497.Google Scholar
Schillie, S, Wester, C, Osborne, M, et al. CDC recommendations for hepatitis C screening among adults – United States, 2020. MMWR Recomm Rep. 2020 Apr 10;69(2):1–17.Google Scholar
Society for Maternal-Fetal Medicine (SMFM). Dotters-Katz, SK, Kuller, JA, Hughes, BL. Society for Maternal-Fetal Medicine Consult Series No. 56: Hepatitis C in pregnancy-updated guidelines: Replaces Consult No. 43, November 2017. Am J Obstet Gynecol. 2021;225(3):B8–B18.Google Scholar
US Preventive Services Task Force Recommendation Statement. Screening for Hepatitis C Virus Infection in Adolescents and Adults. JAMA 2020;323(10):970–975.CrossRefGoogle Scholar

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