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Case 39 - A 25-Year-Old Woman Who Has Received a Letter from an Aunt Recommending Lynch Testing (Cascade Testing)

from Section VI - Cancer Screening and Prevention

Published online by Cambridge University Press:  20 February 2019

David Chelmow
Affiliation:
Virginia Commonwealth University
Nicole W. Karjane
Affiliation:
Virginia Commonwealth University
Hope A. Ricciotti
Affiliation:
Harvard Medical School
Amy E. Young
Affiliation:
University of Texas, Austin
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Office Gynecology
A Case-Based Approach
, pp. 118 - 121
Publisher: Cambridge University Press
Print publication year: 2019

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References

American College of Obstetricians and Gynecologists. Lynch syndrome. Practice bulletin No. 147. Obstet Gynecol 2014;124:10421054.CrossRefGoogle Scholar
Barrow, E, Hill, J, Evans, DG. Cancer risk in Lynch syndrome. Fam Cancer 2013;12(2):229240.Google Scholar
Nakamura, K, Banno, K, Yanokura, M et al. Features of ovarian cancer in Lynch syndrome. Mol Clin Oncol. 2014;2(6):909916.Google Scholar
Lu, KH, Dinh, M, Kohlmann, W et al. Gynecologic cancer as a “sentinel cancer” for women with hereditary nonpolyposis colorectal cancer syndrome. Obstet Gynecol 2005;105:569574.Google Scholar
Vasen, H, Watson, P, Mecklin, JP, Lynch, H. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology 1999;116(6):14531456.CrossRefGoogle Scholar
Umar, A, Boland, CR, Terdiman, JP et al. Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 2004;96(4):261268.Google Scholar
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Lindor, NM, Petersen, GM, Hadley, DW et al. Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review. JAMA 2006;296:15071517.Google Scholar
Burn, J, Gerdes, AM, Macrae, F et al. CAPP2 Investigators: long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet 2011;378:20812087.Google Scholar
Schmeler, K, Lynch, HT, Chen, L et al. Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch Syndrome. N Engl J Med 2006;354:261269.CrossRefGoogle ScholarPubMed
Hampel, H. Genetic counseling and cascade genetic testing in Lynch syndrome. Fam Cancer 2016;15:423427.CrossRefGoogle ScholarPubMed
Stoffel, EM, Ford, B, Mercado, RC et al. Sharing genetic test results in Lynch syndrome: communication with close and distant relatives. Clin Gastroenterol Hepatol 2008;6(3):333338.CrossRefGoogle ScholarPubMed
American Medical Association, Code of Medical Ethics. Opinion E-2.131: Disclosure of Familial Risk in Genetic Testing. www.ama-assn.org/ama/pub/physician-resources/medical-ethics/code-medical-ethics/opinion2131.page. Accessed 11 January 2013.Google Scholar

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