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Chapter 24 - Nerve sheath tumors

Published online by Cambridge University Press:  19 October 2016

Markku Miettinen
Affiliation:
National Cancer Institute, Maryland
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Modern Soft Tissue Pathology
Tumors and Non-Neoplastic Conditions
, pp. 637 - 693
Publisher: Cambridge University Press
Print publication year: 2016

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References

Primary Sources

Antonescu, CR, Scheithauer, BW, Woodruff, JM. Tumors of the Peripheral Nervous System. AFIP Atlas of Tumor Pathology, Fourth series, fascicle 19. Silver Spring, Maryland: ARP Press, 2013.CrossRefGoogle Scholar

Secondary Sources

Louhimo, I, Rapola, J. Intraneural muscular hamartoma: a report of two cases in small children. J Pediatr Surg 1972;7:696699.Google Scholar
Markel, SF, Enzinger, FM. Neuromuscular hamartoma: a benign “triton tumor” composed of mature neural and striated muscle elements. Cancer 1982;49:140144.Google Scholar
Bonneau, R, Brochu, P. Neuromuscular choristoma: a clinicopathologic study of two cases. Am J Surg Pathol 1983;7:521528.CrossRefGoogle ScholarPubMed
Mitchell, A, Scheithauer, BW, Ostertag, H, Sepehrnia, A, Sav, A. Neuromuscular choristoma. Am J Clin Pathol 1995;103:460465.Google Scholar
Tiffee, JC, Barnes, EL. Neuromuscular hamartomas of the head and neck. Arch Otolaryngol Head Neck Surg 1998;124: 212216.CrossRefGoogle ScholarPubMed
Azzopardi, JG, Eusebi, V, Tison, V, Betts, BM. Neurofibroma with rhabdomyomatous differentiation: benign “Triton” tumor of the vagina. Histopathology 1983;7:561572.CrossRefGoogle Scholar
Wu, KK. Morton neuroma and metatarsalgia. Curr Opin Rheumatol 2000;12:131142.CrossRefGoogle ScholarPubMed
Bennett, GL, Graham, CE, Mauldin, DM. Morton’s interdigital neuroma: a comprehensive treatment protocol. Foot Ankle Int 1995;16:760763.Google Scholar
Saygi, B, Yildirim, Y, Saygi, EK, Kara, H, Esemenli, T. Morton neuroma: comparative results of two conservative methods. Foot Ankle Int 2005;26:556559.CrossRefGoogle ScholarPubMed
Reed, RJ, Bliss, BO. Morton’s neuroma: regressive and productive intermetatarsal elastofibrositis. Arch Pathol 1973;95:123129.Google Scholar
Lassmann, G, Lassmann, H, Stockinger, L. Morton’s metatarsalgia: light and electron microscopic observations and their relation to entrapment neuropathies. Virchows Arch A Pathol Anat Histopathol 1976;370:307321.CrossRefGoogle ScholarPubMed
Bourke, G, Owen, J, Machet, D. Histological comparison of the third interdigital nerve in patients with Morton’s metatarsalgia and control patients. Aust N Z J Surg 1994;64:421424.Google Scholar
Vernadakis, AJ, Koch, H, Mackinnon, SE. Management of neuromas. Clin Plast Surg 2003;30:247268.Google Scholar
Larson, DM, Storsteen, KA. Traumatic neuroma of the bile ducts with intrahepatic extension causing obstructive jaundice. Hum Pathol 1984;15:287289.Google Scholar
van Gulik, TM, Brummelkamp, WH, Lygidakis, NJ. Traumatic neuroma giving rise to biliary obstruction after reconstructive surgery for iatrogenic lesions of the biliary tract: a report of three cases. Hepatogastroenterology 1989;36:255257.Google Scholar
Carney, JA, Sizemore, GW, Hayles, AB. Multiple endocrine neoplasia type 2b. Pathobiol Annu 1978;8:105153.Google ScholarPubMed
Giangarella, J, Jagirdar, J, Adelman, H, Budzilovich, G, Greco, MA. Mucosal neuromas and plexiform neurofibromas: an immunocytochemical study. Pediatr Pathol 1993;13:281288.Google Scholar
d’Amore, ESG, Manivel, JC, Pettinato, G, Niehans, GA, Snover, DC. Intestinal ganglioneuromatosis: mucosal and transmural types. A clinicopathologic and immunohistochemical study of six cases. Hum Pathol 1991;22:276286.Google Scholar
Shekitka, KM, Sobin, LH. Ganglioneuromas of the gastrointestinal tract: relation to von Recklinghausen’s disease and other multiple tumor syndromes. Am J Surg Pathol 1994;18:250257.Google Scholar
Weidner, N, Flanders, DJ, Mitros, FA. Mucosal ganglioneuromatosis associated with multiple colonic polyps. Am J Surg Pathol 1984;8:779786.Google Scholar
Fletcher, CD, Theaker, JM. Digital pacinian neuroma: a distinctive hyperplastic lesion. Histopathology 1989;15:249256.Google Scholar
Reznik, M, Thiry, A, Fridman, V. Painful hyperplasia and hypertrophy of pacinian corpuscles in the hand: report of two cases with immunohistochemical and ultrastructural studies, and a review of the literature. Am J Dermatopathol 1998;20:203207.CrossRefGoogle Scholar
Satge, D, Nabhan, J, Nandiegou, Y, et al. A pacinian hyperplasia of the foot. Foot Ankle Int 2001;22:342344.Google Scholar
Yan, S, Horangic, NJ, Harris, BT. Hypertrophy of Pacinian corpuscles in a young patient with neurofibromatosis. Am J Dermatopathol 2006;28:202204.Google Scholar
MacDonald, DM, Wilson-Jones, E. Pacinian neurofibroma. Histopathology 1977;1:247255.Google Scholar
Reed, RJ, Fine, RM, Meltzer, HD. Palisaded, encapsulated neuromas of the skin. Arch Dermatol 1972;106:865870.Google Scholar
Fletcher, CD. Solitary circumscribed neuroma (so-called palisaded encapsulated neuroma): a clinicopathologic and immunohistochemical study. Am Surg Pathol 1989;13:574580.Google Scholar
Dover, JS, From, L, Lewis, A. Palisaded encapsulated neuromas: a clinicopathologic study. Arch Dermatol 1989;125:386389.CrossRefGoogle ScholarPubMed
Dakin, MC, Leppard, B, Theaker, JM. The palisaded encapsulated neuroma (solitary circumscribed neuroma). Histopathology 1992;20:405410.Google Scholar
Koutlas, IG, Scheithauer, BW. Palisaded encapsulated (“solitary circumscribed”) neuroma of the oral cavity: a review of 55 cases. Head Neck Pathol 2010;4:1526.Google Scholar
Navarro, M, Vilata, H, Requena, C, Aliaga, A. Palisaded encapsulated neuroma (solitary circumscribed neuroma) of the glans penis. Br J Dermatol 2000;142:10611062.Google Scholar
Argenyi, ZB, Cooper, PH, Santa, Cruz D. Plexiform and other unusual variants of palisaded encapsulated neuroma. J Cutan Pathol 1993;20:3439.CrossRefGoogle ScholarPubMed
Albrecht, S, Kahn, HJ, From, L. Palisaded encapsulated neuroma: an immunohistochemical study. Mod Pathol 1989;2:403406.Google Scholar
Argenyi, ZB. Immunohistochemical characterization of palisaded, encapsulated neuroma. J Cutan Pathol 1990;17:329335.Google Scholar
Reed, ML, Jacoby, RA. Cutaneous neuroanatomy and neuropathology. Am J Dermatopathol 1983;5:335362.Google Scholar
Fletcher, CD. Peripheral nerve sheath tumors: a clinicopathologic update. Pathol Ann 1990;25(Part 1):5374.Google ScholarPubMed
Megahed, M. Histopathological variants of neurofibroma: a study of 114 lesions. Am J Dermatopathol 1994;16:486495.Google Scholar
Requena, L, Sangueza, OP. Benign neoplasms with neural differentiation: a review. Am J Dermatopathol 1995;17:7596.Google Scholar
Michal, M, Fanburg-Smith, JC, Mentzel, T, et al. Dendritic cell neurofibroma with pseudorosettes: a report of 18 cases of a distinct and hitherto unrecognized neurofibroma variant. Am J Surg Pathol 2001;25:587594.Google Scholar
Lin, BT, Weiss, LM, Medeiros, LJ. Neurofibroma and cellular neurofibroma with atypia: a report of 14 tumors. Am J Surg Pathol 1997;21:14431449.CrossRefGoogle ScholarPubMed
Kaiserling, E, Geerts, ML. Tumour of Wagner–Meissner touch corpuscles: a Wagner–Meissner neurilemmoma. Virchows Arch A Pathol Anat Histopathol 1986;409:241250.Google Scholar
Fetsch, JF, Michal, M, Miettinen, M. Pigmented (melanotic) neurofibroma: a clinicopathologic and immunohistochemical analysis of 19 lesions from 17 patients. Am J Surg Pathol 2000;24:331343.Google Scholar
Weiss, SW, Langloss, JM, Enzinger, FM. Value of S100-protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. Lab Invest 1983;49:299308.Google Scholar
Weiss, SW, Nickoloff, BJ. CD34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors and related lesions. Am J Surg Pathol 1993;17:10391045.Google Scholar
Chaubal, A, Paetau, A, Zoltick, P, Miettinen, M. CD34 immunoreactivity in nervous system tumors. Acta Neuropathol 1994;88:454458.Google Scholar
Perentes, E, Rubinstein, LJ. Immunohistochemical recognition of human nerve sheath tumors by anti-Leu 7 antibodies (HNK-1) monoclonal antibody. Acta Neuropathol 1986;69:227233.Google Scholar
Chanoki, M, Ishii, M, Fukai, K, et al. Immunohistochemical localization of type I, III, IV, V and VI collagens and laminin in neurofibroma and neurofibrosarcoma. Am J Dermatopathol 1991;13:365373.Google Scholar
Kindblom, LG, Ahlden, M, Meis-Kindblom, JM, Stenman, G. Immunohistochemical and molecular analysis of p53, MDM2, proliferating cell nuclear antigen and Ki-67 in benign and malignant nerve sheath tumors. Virchows Arch 1995;427:1926.Google Scholar
Halling, KC, Scheithauer, BW, Halling, AC, et al. p53 expression in neurofibroma and malignant peripheral nerve sheath tumor: an immunohistochemical study of sporadic and NF1-associated tumors. Am J Clin Pathol 1996;106:282288.Google Scholar
Erlandson, RA, Woodruff, JM. Peripheral nerve sheath tumors: an electron microscopic study of 43 cases. Cancer 1982;49:273287.Google Scholar
Sorensen, SA, Mulvihill, JJ, Nielsen, A. Long-term follow-up of von Recklinghausen neurofibromatosis: survival and malignant neoplasms. N Engl J Med 1986;314:10101015.Google Scholar
Mulvihill, JJ, Parry, DM, Sherman, JL, et al. NIH conference: neurofibromatosis 1 (Recklinghausen disease) and neurofibromatosis 2 (bilateral acoustic neurofibromatosis). An update. Ann Intern Med 1990;113:3952.Google Scholar
Gutmann, DH, Aylsworth, A, Carey, JC, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997;278:5157.Google Scholar
Shen, MH, Harper, PS, Upadhyay, M. Molecular genetics of neurofibromatosis type 1 (NF1). J Med Genet 1996;22:217.Google Scholar
Rasmussen, SA, Friedman, JM. NF1 gene and neurofibromatosis 1. Am J Epidemiol 2000;151:3340.CrossRefGoogle ScholarPubMed
Serra, E, Puig, S, Otero, D, et al. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. J Med Genet 1997;61:512519.Google Scholar
Sawada, S, Florell, S, Purandare, SM, et al. Identification of NF1 mutations in both alleles of a dermal neurofibroma. Nat Genet 1996;14:110112.Google Scholar
Kluwe, L, Friedrich, R, Mautner, VF. Loss of NF1 allele in schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma. Genes Chromosomes Cancer 1999;24:283285.3.0.CO;2-K>CrossRefGoogle Scholar
Eisenbarth, I, Beyer, K, Krone, W, Assum, G. Toward a survey of somatic mutation of the NF1 gene in benign neurofibromas of patients with neurofibromatosis type 1. Am J Hum Genet 2000;66:393401.CrossRefGoogle Scholar
John, AM, Ruggieri, M, Ferner, R, Upadhyaya, M. A search for evidence of somatic mutations in the NF1 gene. J Med Genet 2000;37:4449.Google Scholar
Messiaen, LM, Callens, T, Mortier, G, et al. Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects. Hum Mutat 2000;15:541555.Google Scholar
Jung, EG. Segmental neurofibromatosis. Neurofibromatosis 1988;1:306311.Google Scholar
Listernick, R, Mancini, AJ, Charrow, J. Segmental neurofibromatosis in childhood. Am J Med Genet A 2003;121A:132135.Google Scholar
Tinschert, S, Naumann, I, Stegmann, E, et al. Segmental neurofibromatosis is caused by somatic mutation of the neurofibromatosis type 1 (NF1) gene. Eur J Hum Genet 2000;8:455459.Google Scholar
Colman, SD, Rasmussen, SA, Ho, VT, Abernathy, CR, Wallace, MR. Somatic mosaicism in a patient with neurofibromatosis type 1. Am J Hum Genet 1996;58:484490.Google Scholar
Das Gupta, TK, Brasfield, RD, Strong, EW, Hajdu, SI. Benign solitary schwannomas (neurilemomas). Cancer 1969;24:355366.Google Scholar
Alvarado-Cabrero, I, Folpe, AL, Srigley, JR, et al. Intararenal schwannoma: a report of four cases including three cellular variants. Mod Pathol 2000;13:851856.Google Scholar
Dahl, I. Ancient neurilemmoma (schwannoma). Acta Pathol Microbiol Scand A 1977;85:812818.Google Scholar
Gould, VE, Moll, R, Moll, I, Lee, I, Schwechheimer, K. The intermediate filament complement of the spectrum of nerve sheath neoplasms. Lab Invest 1986;55:463474.Google Scholar
Kawahara, E, Oda, Y, Ooi, A, et al. Expression of glial fibrillary acidic protein (GFAP) in peripheral nerve sheath tumors: a comparative study of immunoreactivity of GFAP, vimentin, S100-protein and neurofilament in 38 schwannomas and 18 neurofibromas. Am J Surg Pathol 1988;12:115120.Google Scholar
Kaiserling, E, Xiao, JC, Ruck, P, Horny, HP. Aberrant expression of macrophage-associated antigens (CD68 and Ki-M1P) by Schwann cells in reactive and neoplastic neural tissue. Mod Pathol 1994;6:463468.Google Scholar
Gray, MH, Rosenberg, AE, Dickersin, GR, Bhan, AK. Glial fibrillary acidic protein and keratin expression by benign and malignant nerve sheath tumors. Hum Pathol 1989;20:10891096.Google Scholar
Oda, Y, Kawahara, E, Minamoto, T, Tsuenyoshi, M. Immunohistochemical studies on the tissue localization of collagen types I, III, IV, V and VI in schwannomas. Virchows Arch B Cell Pathol Incl Mol Pathol 1988;56:153163.Google Scholar
Waggener, JD. Ultrastructure of benign peripheral nerve sheath tumors. Cancer 1966;19:699709.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Dickersin, GR. The electron microscopic spectrum of nerve sheath neoplasms. Ultrastruct Pathol 1987;11:103146.Google Scholar
Woodruff, JM, Godwin, TA, Erlandson, RA, Susin, M, Martini, N. Cellular schwannoma: a variety of schwannoma sometimes mistaken for a malignant tumor. Am J Surg Pathol 1981;5:733744.Google Scholar
Lodding, P, Kindblom, LG, Angervall, L, Stenman, G. Cellular schwannoma: a clinicopathologic study of 29 cases. Virchows Arch A Pathol Anat Histopathol 1990;416:237244.CrossRefGoogle ScholarPubMed
White, W, Shiu, MH, Rosenblum, MK, Erlandson, RA, Woodruff, JM. Cellular schwannoma: a clinicopathologic study of 57 patients and 58 tumors. Cancer 1990;66:12661275.Google Scholar
Casadei, GR, Scheihauer, BW, Hirose, T, et al. Cellular schwannoma: a clinicopathologic, DNA flow-cytometric and proliferation marker study of 71 cases. Cancer 1995;75:11091119.Google Scholar
Woodruff, JM, Marshall, ML, Goodwin, TA, et al. Plexiform (multinodular) schwannoma: a tumor simulating plexiform neurofibroma. Am J Surg Pathol 1983;7:691697.Google Scholar
Fletcher, CDM, Davies, SE. Benign plexiform (multinodular) schwannoma: a rare tumor unassociated with neurofibromatosis. Histopathology 1986;10:971980.Google Scholar
Iwashita, T, Enjoji, M. Plexiform neurilemmoma: a clinicopathological and immunohistochemical analysis of 23 tumors from 20 patients. Virchows Arch 1987;411:305309.Google Scholar
Kao, GR, Laskin, WB, Olsen, TG. Solitary cutanenous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. Mod Pathol 1989;2:2026.Google Scholar
Hirose, T, Scheithauer, BW, Sano, T. Giant plexiform schwannoma: a report of two cases with soft tissue and visceral involvement. Mod Pathol 1997;10:10751081.Google Scholar
Agaram, NP, Prakash, S, Antonescy, CR. Deep-seated plexiform schwannoma. Am J Surg Pathol 2005;29:10421048.Google Scholar
Ishida, T, Kuroda, M, Motoi, T, et al. Phenotypic diversity of neurofibromatosis 2: association with plexiform schwannoma. Histopathology 1998;32:264270.Google Scholar
Woodruff, JM, Scheithauer, BW, Kurtakaya-Yapicier, O, et al. Congenital and childhood plexiform (multinodular) schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor. Am J Surg Pathol 2003;27:13211329.Google Scholar
Kindblom, LG, Meis-Kindblom, JM, Havel, G, Busch, C. Benign epithelioid schwannoma. Am J Surg Pathol 1998;22:762770.Google Scholar
Goldblum, JR, Beals, TF, Weiss, SW. Neuroblastoma-like neurilemoma. Am J Surg Pathol 1994;18:266273.Google Scholar
Woodruff, JM, Selig, AM, Crowley, K, Allen, RW. Schwannoma (neurilemmoma) with malignant transformation: a rare, distinctive peripheral nerve tumor. Am J Surg Pathol 1994;18:882895.Google Scholar
Joste, NE, Racz, MI, Montgomery, KD, et al. Clonal chromosome abnormalities in a plexiform schwannoma. Cancer Genet Cytogenet 2004;150:7377.Google Scholar
Mentzel, T, Katenkamp, D. Intraneural angiosarcoma and angiosarcoma arising in benign and malignant peripheral nerve sheath tumours: clinicopathological and immunohistochemical analysis of four cases. Histopathology 1999;35:114120.Google Scholar
Ruckert, RI, Fleige, B, Rogalla, P, Woodruff, JM. Schwannoma with angiosarcoma: report of a case and comparison with other types of nerve sheath tumors with angiosarcoma. Cancer 2000;89:15771585.Google Scholar
McMenamin, ME, Fletcher, CD. Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma. A study of 17 cases. Am J Surg Pathol 2001;25:1325.Google Scholar
Rouleau, GA, Merel, P, Lutchman, M, et al. Alteration in a new gene encoding a putative membrane-organizing protein causes neurofibromatosis type 2. Nature 1993;363:515521.Google Scholar
Trofatter, JA, MacCollin, MM, Rutter, JL, et al. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 1993;72:791800.Google Scholar
Louis, DN, Ramesh, V, Gusella, JF. Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors. Brain Pathol 1995;5:163172.Google Scholar
Evans, DG, Sainio, M, Baser, ME. Neurofibromatosis type 2. J Med Genet 2000;37:897904.Google Scholar
Giovannini, M, Robanus-Maandag, E, Niwa-Kawakita, M, et al. Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein. Genes Dev 1999;15:978986.Google Scholar
Ruttledge, MH, Andermann, AA, Phelan, CM, et al. Type of mutation in the neurofibromatosis 2 gene frequently determines severity of disease. Am J Hum Genet 1996;59:331342.Google Scholar
Parry, DM, McCollin, MM, Kaiser-Kupfer, MI, et al. Germ-line mutations in the neurofibromatosis 2 gene: correlations with disease severity and retinal abnormalities. Am J Hum Genet 1996;59:529539.Google Scholar
Kimura, Y, Saya, H, Nakao, M. Calpain-dependent proteolysis of NF2 protein: involvement in schwannomas and meningiomas. Neuropathology 2000;20:153160.Google Scholar
Purcell, SM, Dixon, SL. Schwannomatosis: an unusual variant of neurofibromatosis or a distinct clinical entitity. Arch Dermatol 1989;125:390393.CrossRefGoogle ScholarPubMed
MacCollin, M, Woodfin, W, Kronn, D, Short, MP. Schwannomatosis: a clinical and pathologic study. Neurology 1996;46:10721079.Google Scholar
Evans, DG, Mason, S, Huson, SM, et al. Spinal and cutaneous schwannomatosis is a variant form of type 2 neurofibromatosis: a clinical and molecular study. J Neurol Neurosurg Psychiatry 1997;62:361366.Google Scholar
Jacoby, LB, Jones, D, Davis, K, et al. Molecular analysis of NF2 tumor-suppressor gene in schwannomatosis. Am J Hum Genet 1997;61:12931302.Google Scholar
Seppälä, MT, Sainio, MA, Haltia, MJ, et al. Multiple schwannomas: schwannomatosis or neurofibromatosis type 2? J Neurosurg 1998;89:3641.Google Scholar
Hulsebos, TJ, Plomp, AS, Wolterman, RA, et al. Germline mutation of INI1/SMARCB1 in familial schwannomatosis. Am J Hum Genet 2007;80:805810.Google Scholar
Sestini, R, Bacci, C, Provenzano, A, Genuardi, M, Papi, L. Evidence of a four-hit mechanism involving SMARCB1 and NF2 in schwannomatosis-associated schwannomas. Hum Mutat 2008;29:227231.Google Scholar
Boyd, C, Smith, MJ, Kluwe, L, et al. Alterations in the SMARCB1 (INI1) tumor suppressor gene in familial schwannomatosis. Clin Genet 2008;74:358366.Google Scholar
Swensen, JJ, Keyser, J, Coffin, CM, et al. Familial occurrence of schwannomas and malignant rhabdoid tumour associated with a duplication in SMARCB1. J Med Genet 2009;46:6872.Google Scholar
Rousseau, G, Noguchi, T, Bourdon, V, Sobol, H, Olschwang, S. SMARCB1/INI1 germline mutations contribute to 10% of sporadic schwannomatosis. BMC Neurol 2011;11:9.Google Scholar
Piotrowski, A, Xie, J, Lu, YF, et al. Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas. Nat Genet 2014;46:182187.Google Scholar
Feany, MB, Anthony, DC, Fletcher, CD. Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge. Histopathology 1998;32:405410.Google Scholar
Harder, A, Wesemann, M, Hagel, C, et al. Hybrid neurofibroma/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients. Am J Surg Pathol 2012;36:702709.Google Scholar
Michal, M, Kazakov, DV, Belousova, I, et al. A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. Virchows Arch 2004;445:347353.Google Scholar
Hornick, JL, Bundock, EA, Fletcher, CD. Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol 2009;33:15541561.Google Scholar
Kazakov, DV, Pitha, J, Sima, R, et al. Hybrid peripheral nerve sheath tumors: schwannoma-perineurioma and neurofibroma-perineurioma. A report of three cases in extradigital locations. Ann Diagn Pathol 2005;9:1623.Google Scholar
Daimaru, Y, Kido, H, Hashimoto, H, Enjoji, M. Benign schwannoma of the gastrointestinal tract: a clinicopathologic and immunohistochemical study. Hum Pathol 1988;19:257264.Google Scholar
Sarlomo-Rikala, M, Miettinen, M. Gastric schwannoma: a clinicopathologic analysis of six cases. Histopathology 1995;27:355360.Google Scholar
Prevot, S, Bienvenu, L, Vaillant, JC, de Saint-Maur, PP. Benign schwannoma of the digestive tract: a clinicopathologic and immunohistochemical study of five cases, including a case of esophageal tumor. Am J Surg Pathol 1999;23:431436.Google Scholar
Miettinen, M, Shekitka, KM, Sobin, LH. Schwannomas in the colon and rectum: clinicopathologic and immunohistochemical study of 20 cases. Am J Surg Pathol 2001;25:846855.Google Scholar
Voltaggio, L, Murray, R, Lasota, J, Miettinen, M. Gastric schwannoma: a clinicopathologic study of 51 cases and critical review of the literature. Hum Pathol 2012;43:650659.Google Scholar
Tozbikian, G, Shen, R, Suster, S. Signet ring cell gastric schwannoma: report of a new distinctive morphological variant. Ann Diagn Pathol 2008;12:146152.CrossRefGoogle ScholarPubMed
Liegl, B, Bennett, MW, Fletcher, CD. Microcystic/reticular schwannoma: a distinct variant with predilection for visceral locations. Am J Surg Pathol 2008;32:10801087.Google Scholar
Lewin, MR, Dilworth, HP, Abu Alfa, AK, Epstein, JI, Montgomery, E. Mucosal benign epithelioid nerve sheath tumors. Am J Surg Pathol 2005;29:13101315.Google Scholar
Lasota, J, Wasag, B, Dansonka-Mieskzkowska, A, et al. Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: a study of 20 cases. Lab Invest 2003;83:13611371.CrossRefGoogle ScholarPubMed
Carney, JA. Psammomatous melanotic schwannoma: a distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. Am J Surg Pathol 1990;14:206222.Google Scholar
Thornton, CM, Handley, J, Bingham, EA, Toner, PG, Walsh, MY. Psammomatous melanotic schwannoma arising in the dermis in a patient with Carney’s complex. Histopathology 1992;20:7173.Google Scholar
Torres-Mora, J, Dry, S, Li, X, et al. Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of “melanotic schwannoma”. Am J Surg Pathol 2014;38:94105.Google Scholar
Myers, JL, Bernreuter, W, Dunham, W. Melanotic schwannoma of bone: clinicopathologic, immunohistochemical and ultrastructural features of a rare primary bone tumor. Am J Clin Pathol 1990;93:424429.Google Scholar
Laskin, WB, Fetsch, JF, Lasota, J, Miettinen, M. Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases. Am J Surg Pathol 2005;29:3951.Google Scholar
Harkin, JC, Reed, RJ. Myxoma of nerve sheath: tumors of the peripheral nervous system. In Atlas of Tumor Pathology, 2nd series, fascicle 3. Washington, DC: AFIP; 1969: 6065.Google Scholar
Laskin, WB, Fetsch, JF, Miettinen, M. The “neurothekeoma”. Immunohistochemical analysis distinguishes the true nerve sheath myxoma from its mimics. Hum Pathol 2000;31:12301241.Google Scholar
Fetsch, JF, Laskin, WB, Miettinen, M. Nerve sheath myxoma: a clinicopathological and immunohistochemical analysis of 57 morphologically distinctive, S100 protein- and GFAP-positive, myxoid peripheral nerve sheath tumors with a predilection for the extremities and a high recurrence rate. Am J Surg Pathol 2005;29:16151624.Google Scholar
Gallager, RL, Helwig, EB. Neurothekeoma: a benign cutaneous tumor of neural origin. Am J Clin Pathol 1980;74:759764.Google Scholar
Holden, CA, Wilson-Jones, E, MacDonald, DM. Cutaneous lobular neuromyxoma. Br J Dermatol 1982;106:211215.Google Scholar
Angervall, L, Kindblom, LG, Haglid, K. Dermal nerve sheath myxoma: a light and electron microscopic, histochemical and immunohistochemical study. Cancer 1984;53:17521759.Google Scholar
Pulitzer, DR, Reed, RJ. Nerve sheath myxoma (perineurial myxoma). Am J Dermatopathol 1985;7:409421.Google Scholar
Mincer, HH, Spears, KD. Nerve sheath myxoma in the tongue. Oral Surg Oral Med Oral Pathol 1974;37:428430.Google Scholar
Perentes, E, Nakagawa, Y, Ross, GW, Stanton, C, Rubinstein, LJ. Expression of epithelial membrane antigen in perineurial cells and their derivatives: an immunohistochemical study with multiple markers. Acta Neuropathol 1987;75:160165.Google Scholar
Ariza, A, Bilbao, JM, Rosai, J. Immunohistochemical detection of epithelial membrane antigen in normal perineurial cells and perineurioma. Am J Surg Pathol 1988;12:678683.Google Scholar
Theaker, JM, Fletcher, CD. Epithelial membrane antigen expression by the perineurial cell: further studies of peripheral nerve lesions. Histopathology 1989;14:581591.Google Scholar
Macarenko, RS, Oliveira, AM. A distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med 2007;131:625636.Google Scholar
Lazarus, SS, Trombetta, LD. Ultrastructural identification of a benign perineurial cell tumor. Cancer 1978;41:18231829.Google Scholar
Erlandson, RA. The enigmatic perineurial cell and its participation in tumors and tumorlike entities. Ultrastruct Pathol 1991;15:335351.Google Scholar
Bilbao, JM, Khoury, NJS, Hudson, AR, Briggs, SJ. Perineurioma (localized hypertrophic neuropathy). Arch Pathol Lab Med 1984;108:557560.Google Scholar
Boyanton, BL, Jones, JK, Shenaq, SM, Hicks, MJ, Bhattacharjee, MB. Intraneural perineurioma: a systematic review with illustrative cases. Arch Pathol Lab Med 2007;131:13821392.Google Scholar
Emory, TS, Scheithauer, BW, Hirose, T, et al. Intraneural perineurioma: a clonal neoplasm associated with abnormalities of chromosome 22. Am J Clin Pathol 1995;103:696704.Google Scholar
Fetsch, JF, Miettinen, M. Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults. Am J Surg Pathol 1997;21:14331442.CrossRefGoogle Scholar
Yamaguchi, U, Hasegawa, T, Hirose, T, et al. Sclerosing perineurioma: a clinicopathologic study of five cases and diagnostic utility of immunohistochemical staining for GLUT1. Virchows Arch 2003;443:159163.Google Scholar
Sciot, R, Dal, Cin P. Cutaneous sclerosing perineurioma with cryptic NF2 gene deletion. Am J Surg Pathol 1999;23:849853.Google Scholar
Lasota, J, Fetsch, JF, Wozniak, A, et al. The neurofibromatosis type 2 gene is mutated in perineurial cell tumors: a molecular genetic study of eight cases. Am J Pathol 2001;158:12231229.CrossRefGoogle ScholarPubMed
Brock, JE, Perez-Atayde, AR, Kozakewich, PW, et al. Cytogenetic aberrations in perineurioma: variation with subtype. Am J Surg Pathol 2005;29:11641169.Google Scholar
Ushigome, S, Takakuwa, T, Hyuga, M, Tadokoro, M, Shinagawa, T. Perineurial cell tumor and the significance of the perineurial cells in neurofibroma. Acta Pathol Jpn 1986;36:973987.Google Scholar
Michal, M. Extraneural retiform perineuriomas: a report of four cases. Pathol Res Pract 1999;195:759763.Google Scholar
Graadt van Roggen, JF, McMenamin, ME, Belchis, DA, et al. Reticular perineurioma: a distinctive variant of soft tissue perineurioma. Am J Surg Pathol 2001;25:485493.Google Scholar
Mentzel, T, Kutzner, H. Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of skin and soft tissues. Virchows Arch 2005;447:677682.Google Scholar
Tsang, WY, Chan, JKC, Chow, LTC, Tse, CCH. Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. Am J Surg Pathol 1992;16:756763.Google Scholar
Mentzel, T, Dei Tos, AP, Fletcher, CDM. Perineurioma (storiform perineurial fibroma): clinicopathological analysis of four cases. Histopathology 1994;25:261267.Google Scholar
Giannini, C, Scheithauer, BW, Jenkins, RB, et al. Soft tissue perineurioma: evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol 1997;21:164173.Google Scholar
Rankine, AJ, Filion, PR, Plattewn, MA, Spagnolo, DV. Perineurioma: a clinicopathologic study of eight cases. Pathology 2004;36:309315.Google Scholar
Hornick, JL, Fletcher, CDM. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol 2005;29:845858.Google Scholar
Folpe, AL, Billings, SD, McKenney, JK, et al. Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimics. Am J Surg Pathol 2002;26:16201626.Google Scholar
Hirose, T, Scheithauer, BW, Sano, T. Perineurial malignant peripheral nerve sheath tumor (MPNST): a clinicopathologic, immunohistochemical, and ultrastructural study of seven cases. Am J Surg Pathol 1998;22:13681378.Google Scholar
Zamecnik, M, Michal, M. Malignant peripheral nerve sheath tumor with perineurial cell differentiation (malignant perineurioma). Pathol Int 1999;49:6973.Google Scholar
Rosenberg, AS, Langee, CL, Stevens, GL, Morgan, MB. Malignant peripheral nerve sheath tumor with perineurial cell differentiation: malignant perineurioma. J Cutan Pathol 2002;29:362367.Google Scholar
Lack, EE, Worsham, GF, Callihan, MD, et al. Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol 1980;13:301316.Google Scholar
Ordonez, NG. Granular cell tumor: a review and update. Adv Anat Pathol 1999;6:186203.Google Scholar
Damiani, S, Koerner, FC, Dickersin, GR, Cook, MG, Eusebi, V. Granular cell tumour of the breast. Virchows Arch A Pathol Anat Histopathol 1992;420:219226.Google Scholar
Wolber, RA, Talerman, A, Wilinson, EJ, Clement, PB. Vulvar granular cell tumors with pseudocarcinomatous hyperplasia: a comparative analysis with well-differentiated squamous carcinoma. Int J Gynecol Pathol 1991;10:5966.Google Scholar
Chaudhry, AP, Jacobs, MS, SunderRaj, M, et al. A clinicopathologic study of 50 adult oral granular cell tumors. J Oral Med 1984;39:97103.Google Scholar
Johnston, J, Helwig, EB. Granular cell tumors of the gastrointestinal tract and perianal region: a study of 74 cases. Dig Dis Sci 1981;26:807816.Google Scholar
Compagno, J, Hyams, VJ, Sainte-Marie, P. Benign granular cell tumors of the larynx: a review of 36 cases with clinicopathologic data. Ann Otol Rhinol Laryngol 1975;84:308314.Google Scholar
Deavers, M, Guinee, D, Koss, MN, Travis, WD. Granular cell tumors of the lung: clinicopathologic study of 20 cases. Am J Surg Pathol 1995;19:627635.Google Scholar
Murakata, LA, Ishak, KG. Expression of inhibin-alpha by granular cell tumors of the gallbladder and extrahepatic bile ducts. Am J Surg Pathol 2001;25:12001203.Google Scholar
Melo, CR, Melo, IS, Schmitt, FC, Fagundes, R, Amendola, D. Multicentric granular cell tumor of the colon: report of a patient with 52 tumors. Am J Gastroenterol 1993;88:17851787.Google Scholar
Rifkin, RH, Blocker, SH, Palmer, JO, Ternberg, JL. Multiple granular cell tumors. A familial occurrence in children. Arch Surg 1986;121:945947.Google Scholar
Nakazato, Y, Ishizeki, J, Takahashi, K, Yamaguchi, H. Immunohistochemical localization of S100-protein in granular cell myoblastoma. Cancer 1982;49:16241628.Google Scholar
Mazur, MT, Schultz, JJ, Myers, JL. Granular cell tumor: immunohistochemical analysis of 21 benign tumors and one malignant tumor. Arch Pathol Lab Med 1990;114:692696.Google Scholar
Filie, AC, Lage, JM, Azumi, N. Immunoreactivity of S100-protein, alpha-1-antitrypsin, and CD68 in adult and congenital granular cell tumors. Mod Pathol 1996;9:888892.Google Scholar
Miettinen, M, Lehtonen, E, Lehtola, H, et al. Histogenesis of granular cell tumour: an immunohistochemical and ultrastructural study. J Pathol 1984;142:221229.Google Scholar
Le, BH, Boyer, PJ, Lewis, JE, Kapadia, SB. Granular cell tumor: immunohistochemical assessment of inhibin-α, protein gene product 9.5, S100 protein, CD68, and Ki67 proliferative index with clinical correlation. Arch Pathol Lab Med 2004;128:771775.Google Scholar
Carstens, PH, Yacoub, O. Importance of the angulate bodies in the diagnosis of granular cell tumors (schwannomas). Ultrastruct Pathol 1993;17:271278.Google Scholar
Mentzel, T, Wadden, C, Fletcher, CD. Granular cell change in smooth muscle tumours of skin and soft tissue. Histopathology 1994;24:223231.Google Scholar
Fanburg-Smith, JC, Meis-Kindblom, JM, Fante, R, Kindblom, LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998;22:779794.Google Scholar
Cruz-Mojarrieta, J, Navarro, S, Gomez-Cabrera, E, et al. Malignant granular cell tumor of soft tissues: a study of two new cases. Int J Surg Pathol 2001;9:255259.Google Scholar
Custer, RP, Fust, JA. Congenital epulis. Am J Clin Pathol 1952;2:10441053.Google Scholar
Lack, EE, Worsham, GF, Callihan, MD, Crawford, BE, Vawter, GF. Gingival granular cell tumors of the newborn (congenital “epulis”): a clinical and pathologic study of 21 patients. Am J Surg Pathol 1981;5:3746.Google Scholar
Childers, EL, Fanburg-Smith, JC. Congenital epulis of the newborn: 10 new cases of a rare oral tumor. Ann Diagn Pathol 2011;15:157161.Google Scholar
Park, SH, Kim, TJ, Chi, JG. Congenital granular cell tumor with systemic involvement: immunohistochemical and ultrastructural study. Arch Pathol Lab Med 1991;115:934938.Google Scholar
Rohrer, MD, Young, SK. Congenital epulis (gingival granular cell tumor): ultrastructural evidence of origin from pericytes. Oral Surg Oral Med Oral Pathol 1982;53:5663.Google Scholar
Zarbo, RJ, Lloyd, RV, Beals, TF, McClatchey, KD. Congenital gingival granular cell tumor with smooth muscle cytodifferentiation. Oral Surg Oral Med Oral Pathol 1983;56: 512520.Google Scholar
Takahashi, H, Fujita, S, Satoh, H, Okade, H. Immunohistochemical study of congenital gingival granular cell tumor (congenital epulis). J Oral Pathol Med 1990;19:492496.Google Scholar
Tucker, MC, Rusnock, EJ, Azumi, N, Hoy, GR, Lack, EE. Gingival granular cell tumors of the newborn: an ultrastructural and immunohistochemical study. Arch Pathol Lab Med 1990;114:895898.Google Scholar
Schaefer, IM, Fletcher, CD, Hornicle, JL. Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumor from histologic mimics. Mod Path 2016;29:413.Google Scholar
Ghosh, BC, Ghosh, L, Huvos, AG, Fortner, JG. Malignant schwannoma: a clinicopathologic study. Cancer 1973;31:184190.Google Scholar
Guccion, JG, Enzinger, FM. Malignant schwannoma associated with von Recklinghausen’s neurofibromatosis. Virchows Arch A Pathol Anat Histol 1979;383:4357.Google Scholar
Tsuneyoshi, M, Enjoji, M. Primary malignant peripheral nerve tumors (malignant schwannomas): a clinicopathologic and electron microscopic study. Acta Pathol Jpn 1979;29:363375.Google Scholar
Matsunou, H, Shimoda, T, Kakimoto, S, et al. Histopathologic and immunohistochemical study of malignant tumors of peripheral nerve sheaths (malignant schwannoma). Cancer 1985;56:22692279.Google Scholar
Ducatman, BS, Scheithauer, BW, Piepgras, DW, Reiman, HM, Ilstrup, DM. Malignant peripheral nerve sheath tumors: a clinicopathologic study of 120 cases. Cancer 1986; 57:20062021.Google Scholar
Vauthey, JN, Woodruff, JM, Brennan, MF. Extremity malignant peripheral nerve sheath tumors (neurogenic sarcomas): a 10-year experience. Ann Surg Oncol 1995;2:126131.Google Scholar
Hruban, RH, Shiu, MH, Senie, RT, Woodruff, JM. Malignant peripheral nerve sheath tumors of the buttock and lower extremity: a study of 43 cases. Cancer 1990;66:12531265.Google Scholar
Ducatman, BS, Scheithauer, BW, Piepgras, DG, Reiman, HM. Malignant peripheral nerve sheath tumors in childhood. J Neurooncol 1984;2:241248.Google Scholar
Meis, JM, Enzinger, FM, Martz, KL, Neal, JA. Malignant peripheral nerve sheath tumors (malignant schwannomas) in children. Am J Surg Pathol 1992;16:694707.Google Scholar
Ramanathan, RC, Thomas, JM. Malignant peripheral nerve sheath tumors associated with von Recklinghausen’s neurofibromatosis. Eur J Surg Oncol 1999;25:190193.Google Scholar
Kourea, HP, Bilsky, MH, Leung, DHY, Lewis, JJ, Woodruff, JM. Subdiaphragmatic and intrathoracic paraspinal malignant peripheral nerve sheath tumors: a clinicopathologic study of 25 patients and 26 tumors. Cancer 1998;82:21912203.Google Scholar
Foley, KM, Woodruff, JM, Ellis, FT, Posner, JB. Radiation-induced malignant and atypical peripheral nerve sheath tumors. Ann Neurol 1980;7:311318.Google Scholar
Ducatman, BS, Scheithauer, BW. Postirradiation neurofibrosarcoma. Cancer 1983;51:10281033.Google Scholar
Meis-Kindblom, JM, Enzinger, FM. Plexiform malignant peripheral nerve sheath tumor of infancy and childhood. Am J Surg Pathol 1994;18:479485.Google Scholar
Woodruff, JM, Erlandson, RA, Scheithauer, BW. Nerve sheath tumors: letter to the editor. Am J Surg Pathol 1995;19:608609.Google Scholar
Daimaru, Y, Hashimoto, H, Enjoji, M. Malignant peripheral nerve sheath tumors (malignant schwannomas): an immunohistochemical study of 29 cases. Am J Surg Pathol 1985;9:434444.Google Scholar
Wick, MR, Swanson, PE, Scheithauer, BW, Manivel, JC. Malignant peripheral nerve sheath tumors: an immunohistochemical study of 62 cases. Am J Clin Pathol 1987;87:425433.Google Scholar
Herrera, GA, de Moraes, PH. Neurogenic sarcoma in patients with neurofibromatosis (von Recklinghausen’s disease): light, electron microscopy and immunohistochemistry study. Virchows Arch A Pathol Anat Histopathol 1984;403:361376.Google Scholar
Jhanwar, SC, Chen, Q, Li, FP, Brennan, MF, Woodruff, JM. Cytogenetic analysis of soft tissue sarcomas: recurrent chromosome abnormalities in malignant peripheral nerve sheath tumors (MPNST). Cancer Genet Cytogenet 1994;78:138144.Google Scholar
Plaat, BEC, Molenaar, WM, Mastik, MF, et al. Computer-assisted cytogenetic analysis of 51 malignant peripheral-nerve-sheath tumors: sporadic versus neurofibromatosis-type-1 associated malignant schwannomas. Int J Cancer 1999;83:171178.Google Scholar
Mertens, F, Dal Cin, P, de Wever, I, et al. Cytogenetic characterization of peripheral nerve sheath tumours: a report of the CHAMP study group. J Pathol 2000;190:3138.Google Scholar
Kourea, HP, Orlow, I, Scheithauer, BW, Cordon-Cardo, C, Woodruff, JM. Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas. Am J Pathol 1999;155:18551860.Google Scholar
Nielsen, GP, Stemmer-Rachamimov, AO, Ino, Y, et al. Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation. Am J Pathol 1999;155:18791884.Google Scholar
Kourea, HP, Cordon-Cardo, C, Dudas, M, Leung, D, Woodruff, JM. Expression of p27 (kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27 (kip) in malignant transformation of neurofibroma. Am J Pathol 1999;155:18851891.Google Scholar
Brooks, JSJ, Freeman, M, Enterline, HT. Malignant “Triton” tumors: natural history and immunohistochemistry of nine new cases with literature review. Cancer 1985;55:25432549.Google Scholar
Woodruff, JM, Chernik, NL, Smith, MC, Millett, WB, Foote, FW. Peripheral nerve tumors with rhabdomyosarcomatous differentiation (malignant “triton” tumors). Cancer 1973;32:426439.Google Scholar
Daimaru, Y, Hashimoto, H, Enjoji, M. Malignant “triton” tumors: a clinicopathologic and immunohistochemical study of nine cases. Hum Pathol 1984;15:768778.Google Scholar
Ducatman, BS, Scheithauer, BW. Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer 1984;54:10491057.Google Scholar
Woodruff, JM. Peripheral nerve sheath tumors showing glandular differentiation (glandular schwannomas). Cancer 1976;37:23992413.Google Scholar
Christensen, WN, Strong, EW, Bains, MS, Woodruff, JM. Neuroendocrine differentiation in glandular peripheral nerve sheath tumor: pathologic distinction from the biphasic synovial sarcoma with glands. Am J Surg Pathol 1988;12:417426.Google Scholar
Lodding, P, Kindblom, LG, Angervall, L. Epithelioid malignant schwannoma: a study of 14 cases. Virchows Arch A Pathol Anat Histopathol 1986;409:433451.Google Scholar
DiCarlo, EF, Woodruff, JM, Bansal, M, Erlandson, RA. The purely epithelioid malignant peripheral nerve sheath tumor. Am J Surg Pathol 1986;10:478490.Google Scholar
Laskin, WB, Weiss, SW, Bratthauer, GL. Epithelioid variant of malignant peripheral nerve sheath tumor (malignant epithelioid schwannoma). Am J Surg Pathol 1991;15:11361145.Google Scholar
Jo, VY, Fletcher, CD. Epithelioid malignant peripheral nerve sheath tumor: clinicopathologic analysis of 53 cases. Am J Surg Pathol 2015;39:673682.Google Scholar
Ricci, A, Parham, DM, Woodruff, JM, et al. Malignant peripheral nerve sheath tumors arising from ganglioneuromas. Am J Surg Pathol 1984;8:1929.Google Scholar
Fletcher, CD, Fernando, IN, Braimbridge, MV, McKee, PH, Lyall, JR. Malignant nerve sheath tumor arising in a ganglioneuroma. Histopathology 1988;12:445448.Google Scholar
Damiani, S, Manetto, V, Carrillo, G, et al. Malignant peripheral nerve sheath tumor arising in a de novo ganglioneuroma. Tumori 1991;77:9093.Google Scholar
Min, KW, Clemens, A, Bell, J, Dick, H. Malignant peripheral nerve sheath tumor and pheochromocytoma: a composite tumor of the adrenal. Arch Pathol Lab Med 1988;112:266270.Google Scholar
Miettinen, M, Saari, A. Pheochromocytoma combined with malignant schwannoma: unusual neoplasm of the adrenal medulla. Ultrastruct Pathol 1988;12:513527.Google Scholar

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