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Chapter 22 - Hemangioendotheliomas, angiosarcomas, and Kaposi’s sarcoma

Published online by Cambridge University Press:  19 October 2016

Markku Miettinen
Affiliation:
National Cancer Institute, Maryland
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Modern Soft Tissue Pathology
Tumors and Non-Neoplastic Conditions
, pp. 593 - 623
Publisher: Cambridge University Press
Print publication year: 2016

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References

Primary Sources

Dabska, M. Malignant endovascular papillary angioendothelioma of the skin in childhood: clinicopathologic study of six cases. Cancer 1969;24:503510.Google Scholar
Schwartz, RA, Dabski, C, Dabska, M. The Dabska tumor: a thirty-year retrospective. Dermatology 2000;201:15.CrossRefGoogle Scholar
Fanburg-Smith, JC, Michal, M, Partanen, TA, Alitalo, K, Miettinen, M. Papillary intralymphatic angioendothelioma (PILA): a report of twelve cases of a distinctive vascular tumor with phenotypic features of lymphatic vessels. Am J Surg Pathol 1999;23:10041010.Google Scholar
Emanuel, PO, Lin, R, Silver, L, et al. Dabska tumor arising in lymphangioma circumscriptum. J Cutan Pathol 2008;35:6569.Google Scholar
Calonje, E, Fletcher, CD, Wilson-Jones, E, Rosai, J. Retiform hemangioendothelioma: a distinctive form of low-grade angiosarcoma delineated in a series of 15 cases. Am J Surg Pathol 1994;18:115125.Google Scholar
Kempson, RL, Fletcher, CDM, Evans, HL, Hendrickson, MR, Sibley, RK. Vascular tumors. In Atlas of Soft Tissue Tumors. Washington, DC: AFIP; 2001: 307370.Google Scholar
Duke, D, Dvorak, AM, Harris, TJ, Cohen, LM. Multiple retiform hemangioendotheliomas: a low grade angiosarcoma. Am J Dermatopathol 1996;18:606610.Google Scholar
Parsons, A, Sheehan, DJ, Sangueza, OP. Retiform hemangioendotheliomas usually do not express D2–40 and VEGFR-3. Am J Dermatopathol 2008;30:3133.Google Scholar

Secondary Sources

Weiss, SW, Enzinger, FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer 1982;50:970981.Google Scholar
Weiss, SW, Ishak, KG, Dail, DH, Sweet, DE, Enzinger, FM. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol 1986;3:259287.Google Scholar
Mentzel, T, Beham, A, Calonje, E, Katenkamp, D, Fletcher, CD. Epithelioid hemangioendothelioma of skin and soft tissues: clinicopathologic and immunohistochemical study of 30 cases. Am J Surg Pathol 1997;21:363374.CrossRefGoogle ScholarPubMed
Ishak, KG, Sesterhenn, IA, Goodman, ZD, Rabin, L, Stromeyer, FW. Epithelioid hemangioendothelioma of the liver: a clinicopathologic and follow-up study of 32 cases. Hum Pathol 1984;15:839852.Google Scholar
Kelleher, MB, Iwatsuki, S, Sheahan, DG. Epithelioid hemangioendothelioma of liver: clinicopathological correlations of 10 cases treated by orthotopic liver transplantation. Am J Surg Pathol 1989;13:9991008.Google Scholar
Makhlouf, HR, Ishak, KG, Goodman, ZD. Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer 1999;85:562582.Google Scholar
Dail, DH, Liebow, AA. Gmelich, JT. Intravascular bronchioloalveolar tumor of lung: an analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer 1983;51:452464.Google Scholar
Bagan, P, Hassan, M, Le Pimpec Barthes, F, et al. Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature. Ann Thorac Surg 2006;82:20102013.Google Scholar
Verbeken, E, Beyls, J, Moerman, P, et al. Lung metastasis of malignant epithelioid hemangioendothelioma mimicking a primary intravascular bronchioalveolar tumor: a histologic, ultrastructural, and immunohistochemical study. Cancer 1985;55:17411746.Google Scholar
Sortini, A, Santini, M, Carcoforo, P, et al. Primary lung epithelioid hemangioendothelioma with multiple bilateral metachronous localizations: case report and review. Int Surg 2000;85:336338.Google Scholar
Attanoos, RL, Suvarna, SK, Rhead, E, et al. Malignant vascular tumours of the pleura in “asbestos” workers and endothelial differentiation in malignant mesothelioma. Thorax 2000;55:860863.Google Scholar
Deyrup, AT, Tighiouart, M, Montag, AG, Weiss, SW. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol 2008;32:924927.Google Scholar
Miettinen, M, Fetsch, JF. Distribution of keratins in normal endothelial cells and in a spectrum of vascular tumors: implications in tumor diagnosis. Hum Pathol 2000;31:10621067.Google Scholar
Errani, C, Zhang, L, Sung, YS, et al. A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer 2011;50:644653.Google Scholar
Tanas, MR, Sboner, A, Oliveira, AM, et al. Identification of a disease-defining gene fusion epithelioid hemangioendothelioma. Sci Transl Med 2011;3:98ra82.Google Scholar
Mendlick, MR, Nelson, M, Pickering, D, et al. Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma. Am J Surg Pathol 2001;25:684687.Google Scholar
Antonescu, CR, Le Loarer, F, Mosquera, JM, et al. Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma. Genes Chromosomes Cancer 2013;52:775784.Google Scholar
Flucke, U, Vogels, RJ, de Saint Aubain Somerhausen, N, et al. Epithelioid hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol 2014;9:131.Google Scholar
Billings, SD, Folpe, AL, Weiss, SW. Epithelioid sarcoma-like hemangioendothelioma. Am J Surg Pathol 2003;27:4857.Google Scholar
Hornick, JL, Fletcher, CD. Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent behavior. Am J Surg Pathol 2011;35:190201.Google Scholar
Amary, MF, O'Donnell, P, Berisha, F, et al. Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma: characterization of five cases. Skeletal Radiol 2013;42:947957.CrossRefGoogle ScholarPubMed
Trombetta, D, Magnusson, L, von Steyern, FV, et al. Translocation t(7;19)(q22;q13): a recurrent chromosome aberration in pseudomyogenic hemangioendothelioma? Cancer Genet 2011;204:211215.Google Scholar
Toro, JR, Travis, LB, Wu, HJ, et al. Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology, and end results program, 1978–2001: an analysis of 26,758 cases. Int J Cancer 2006;119:29222930.Google Scholar
Fury, MG, Antonescu, CR, Van Zee, KJ, Brennan, MF, Maki, RG. A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy. Cancer J 2005;11:241247.Google Scholar
Abraham, JA, Hornicek, EJ, Kaufman, AM, et al. Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol 2007;14:19531967.Google Scholar
Bocklage, T, Leslie, KO, Yousem, S, Colby, T. Extracutaneous angiosarcoma metastatic to lungs: clinical and pathologic features of twenty-one cases. Mod Pathol 2001;14:12161225.CrossRefGoogle ScholarPubMed
Fayette, J, Martin, E, Piperno-Neumann, S, et al. Angiosarcoma: a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases. Ann Oncol 2007;18:20302036.Google Scholar
Hodgkinson, DJ, Soule, EH, Woods, JE. Cutaneous angiosarcoma of the head and neck. Cancer 1979;44:11061113.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Maddox, JC, Evans, HL. Angiosarcoma of skin and soft tissue: a study of forty-four cases. Cancer 1981;51:19071921.Google Scholar
Pawlik, TM, Paulino, AF, McGinn, CJ, et al. Cutaneous angiosarcoma of the scalp: a multidisciplinary approach. Cancer 2003;98:17161726.Google Scholar
Morgan, MB, Swann, M, Somach, S, Eng, W, Smoller, B. Cutaneous angiosarcoma: a case series with prognostic correlation. J Am Acad Dermatol 2004;50:867874.Google Scholar
Deyrup, AT, McKenney, JK, Tighiouart, M, Folpe, AL, Weiss, SW. Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 89 cases. Am J Surg Pathol 2008;32:7277.Google Scholar
Guadagnolo, BA, Zagars, GK, Araujo, D, et al. Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp. Head Neck 2011;33:661667.Google Scholar
Lindet, C, Neuville, A, Penel, N, et al. Localised angiosarcomas: the identification of prognostic factors and analysis of treatment impact. A retrospective analysis from the French Sarcoma Group (GSF/GETO). Eur J Cancer 2013;49:369376.Google Scholar
Perez, MC, Padhya, TA, Messina, JL, et al. Cutaneous angiosarcoma: a single-institution experience. Ann Surg Oncol 2013;20:33913397.Google Scholar
Otis, CN, Perschel, R, McKhann, C, Merino, MJ, Duray, PH. The rapid onset of cutaneous angiosarcoma after radiotherapy for breast cancer. Cancer 1986;57:21302134.Google Scholar
Monroe, AT, Feigenberg, SJ, Mendenhall, NP. Angiosarcoma after breast-conserving therapy. Cancer 2003;97:18321840.CrossRefGoogle ScholarPubMed
Billings, SD, McKenney, JK, Folpe, AL, Hardacre, MC, Weiss, SW. Cutaneous angiosarcoma following breast-conserving surgery and radiation: an analysis of 27 cases. Am J Surg Pathol 2004;28:781788.Google Scholar
Fodor, J, Orosz, Z, Szabo, E, et al. Angiosarcoma after conservation treatment for breast carcinoma: our experience and review of the literature. J Am Acad Dermatol 2006;54:499504.Google Scholar
Morgan, EA, Kozono, DE, Wang, Q, et al. Cutaneous radiation-associated angiosarcoma of the breast: poor prognosis in a rare secondary malignancy. Ann Surg Oncol 2012;19:38013808.Google Scholar
Seinen, JM, Styring, E, Verstappen, V, et al. Radiation-associated angiosarcoma after breast cancer: high recurrence rate and poor survival despite surgical treatment with R0 resection. Ann Surg Oncol 2012;19:27002706.Google Scholar
D'Angelo, SP, Antonescu, CR, Kuk, D, et al. High-risk features in radiation-associated breast angiosarcomas. Br J Cancer 2013;109:23402346.Google Scholar
Fineberg, S, Rosen, PP. Cutaneous angiosarcoma and atypical vascular lesions of the skin and breast after radiation therapy for breast carcinoma. Am J Clin Pathol 1994;102:757763.Google Scholar
Sener, SF, Milos, S, Feldman, JL, et al. The spectrum of vascular lesions in the mammary skin, including angiosarcoma, after breast conservation treatment for breast cancer. J Am Coll Surg 2001;193:2228.Google Scholar
Brenn, T, Fletcher, CD. Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathological analysis of 42 cases. Am J Surg Pathol 2005;29:983996.Google Scholar
Patton, KT, Deyrup, AT, Weiss, SW. Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma. Am J Surg Pathol 2008;32:943950.Google Scholar
Wolov, RB, Sato, N, Azumi, N, Lack, EE. Intra-abdominal “angiosarcomatosis”: report of two cases after pelvic irradiation. Cancer 1991;67:22752279.Google Scholar
Suzuki, F, Saito, A, Ishi, K, et al. Intra-abdominal angiosarcomatosis after radiotherapy. J Gastroenterol Hepatol 1999;14:289292.Google Scholar
Aitola, P, Poutiainen, A, Nordback, I. Small-bowel angiosarcoma after pelvic irradiation: a report of two cases. Int J Colorect Dis 1999;14:308310.Google Scholar
Yamamoto, T, Iwasaki, Y, Kurosaka, M, Minami, R. Angiosarcoma arising from skeletal hemangiomatosis in an atomic bomb survivor. J Clin Pathol 2001;54:716717.Google Scholar
Rossi, S, Fletcher, CD. Angiosarcoma arising in hemangioma/vascular malformation: report of four cases and review of the literature. Am J Surg Pathol 2002;26:13191329.Google Scholar
Stewart, FW, Treves, N. Lymphangiosarcoma in postmastectomy lymphedema. Cancer 1948;1:16741678.Google Scholar
Woodward, AH, Ivins, JC, Soule, EH. Lymphangiosarcoma arising in chronic lymphedematous extremities. Cancer 1972;30:562572.Google Scholar
Sordillo, P, Chapman, R, Hajdu, SI, Magill, GB, Golbey, RB. Lymphangiosarcoma. Cancer 1981;48:16741679.Google Scholar
Grobmyer, SJ, Daly, JM, Glotzback, RE, Grobmyer, AJ 3rd. Role of surgery in the management of postmastectomy extremity angiosarcoma (Stewart–Treves syndrome). J Surg Oncol 2000;73:182188.Google Scholar
Roy, P, Clark, MA, Thomas, JM. Stewart–Treves syndrome: treatment and outcome in six patients from a single centre. Eur J Surg Oncol 2004;30:982986.Google Scholar
Shon, W, Ida, CM, Boland-Froemming, JM, Rose, PS, Folpe, A. Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature. J Cutan Pathol 2011;38:560564.Google Scholar
Schreiber, H, Barry, FM, Russell, WC, et al. Stewart–Treves syndrome: a lethal complication of postmastectomy lymphedema and regional immune deficiency. Arch Surg 1979;114:8285.Google Scholar
Steingaszner, LC, Enzinger, FM, Taylor, HB. Hemangiosarcoma of the breast. Cancer 1965;18:352361.Google Scholar
Merino, MJ, Berman, M, Carter, D. Angiosarcoma of the breast. Am J Surg Pathol 1983;7:5360.Google Scholar
Rosen, PP, Kimmel, M, Ernsberger, D. Mammary angiosarcoma: the prognostic significance of tumor differentiation. Cancer 1988;62:21452151.Google Scholar
Nascimento, AF, Raut, CP, Fletcher, CD. Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol 2008;32:18961904.Google Scholar
Sher, T, Hennessy, BT, Valero, V, et al. Primary angiosarcomas of the breast. Cancer 2007;110:173178.Google Scholar
Hodgson, NC, Bowen-Wells, C, Moffat, F, Franceschi, D, Avisar, E. Angiosarcoma of the breast: a review of 70 cases. Am J Clin Oncol 2007;30:570573.Google Scholar
Jozefczyk, MA, Rosen, PP. Vascular tumors of the breast. II. Perilobular hemangiomas and hemangiomas. Am J Surg Pathol 1985;9:491503.CrossRefGoogle ScholarPubMed
Lesueur, GC, Brown, RW, Bhathal, PS. Incidence of perilobular hemangioma in the female breast. Arch Pathol Lab Med 1983;107:308310.Google Scholar
Meis-Kindblom, JM, Kindblom, LG. Angiosarcoma of soft tissue: a study of 80 cases. Am J Surg Pathol 1998;22:683697.Google Scholar
Fletcher, CD, Beham, A, Bekir, S, Clarke, AM, Marley, NJ. Epithelioid angiosarcoma of deep soft tissue: a distinctive tumor readily mistaken for an epithelial neoplasm. Am J Surg Pathol 1991;15:915924.Google Scholar
Byers, RJ, McMahon, RF, Freemont, AJ, Parrott, NR, Newstead, CG. Epithelioid angiosarcoma arising in an arteriovenous fistula. Histopathology 1992;21:8789.Google Scholar
Keane, MM, Carney, DN. Angiosarcoma arising from a defunctionalized arteriovenous fistula. J Urol 1993;149:364365.Google Scholar
Wehrli, BM, Janzen, DL, Shokeir, O, et al. Epithelioid angiosarcoma arising in a surgically constructed arteriovenous fistula: a rare complication of chronic immunosuppression in the setting of renal transplantation. Am J Surg Pathol 1998;22:11541159.Google Scholar
Faraq, R, Schulak, JA, Abdul-Karim, FW, Wasman, JK. Angiosarcoma arising in an arteriovenous fistula site in a renal transplant patient: a case report and literature review. Clin Nephrol 2005;63:408412.Google Scholar
Ahmed, I, Hamacher, KL. Angiosarcoma in a chronically immunosuppressed renal transplant recipient: report of a case and review of the literature. Am J Dermatopathol 2002;24:330335.Google Scholar
Neshiwat, LF, Friedland, ML, Suhorr-Lesnick, B, et al. Hepatic angiosarcoma. Am J Med 1992;93:219222.Google Scholar
Popper, H, Thomas, LB, Telles, NC. Development of hepatic angiosarcoma in man induced by vinyl chloride, thorotrast and arsenic. Am J Pathol 1978;92:349376.Google Scholar
Alrenga, DP. Primary angiosarcoma of the liver. Int Surg 1975;60:198203.Google Scholar
Kojiro, M, Nakashima, T, Ito, Y. Thorium dioxide-related angiosarcoma of the liver: pathomorphologic study of 29 autopsy cases. Arch Pathol Lab Med 1985;109:853857.Google Scholar
Lander, JJ, Stanley, RJ, Sumner, HW. Angiosarcoma of the liver associated with Fowler’s solution (potassium arsenate). Gastroenterology 1975;68:15821586.Google Scholar
Selby, DM, Stocker, JT, Ishak, KG. Angiosarcoma of the liver in childhood: a clinicopathologic and follow-up study of 10 cases. Pediatr Pathol 1992;12:485498.Google Scholar
Falk, S, Krishnan, J, Meis, JM. Primary angiosarcoma of the spleen: a clinicopathologic study of 40 cases. Am J Surg Pathol 1993;17:959970.Google Scholar
Neuhauser, T, Derringer, G, Thompson, LDR, et al. Splenic angiosarcoma: a clinicopathologic and immunohistochemical study of 27 cases. Mod Pathol 2000;13:978987.Google Scholar
Mikami, T, Saegusa, M, Akino, F, et al. A Kaposi-like variant of splenic angiosarcoma lacking association with human herpesvirus 8. Arch Pathol Lab Med 2002;126:191194.Google Scholar
Burke, AP, Cowan, D, Virmani, R. Primary sarcoma of the heart. Cancer 1992;69:387395.3.0.CO;2-N>CrossRefGoogle Scholar
Murinello, A, Mendonca, P, Abreu, A, et al. Cardiac angiosarcoma: a review. Rev Port Cardiol 2007;28:577584.Google Scholar
Booth, AM, LeGallo, RD, Stoler, MH, Waldron, PE, Cerilli, LA. Pediatric angiosarcoma of the heart: a unique presentation and metastatic pattern. Pediatr Dev Pathol 2001;4:490495.Google Scholar
Hottenrott, G, Mentzel, T, Peters, A, Schröder, A, Katenkamp, D. Intravascular (“intimal”) epithelioid angiosarcoma: clinicopathological and immunohistochemical analysis of three cases. Virchows Arch 1999;435:473478.Google Scholar
Mena, H, Ribas, JL, Enzinger, FM, Parisi, JE. Primary angiosarcoma of the central nervous system: study of eight cases and review of the literature. J Neurosurg 1991;75:7376.CrossRefGoogle ScholarPubMed
Eusebi, V, Carcangiu, ML, Dina, R, Rosai, J. Keratin-positive epithelioid angiosarcoma of thyroid: a report of four cases. Am J Surg Pathol 1990;14:737747.Google Scholar
Fanburg-Smith, JC, Furlong, MA, Childers, EL. Oral and salivary gland angiosarcoma: a clinicopathologic study of 29 cases. Mod Pathol 2003;16:263271.Google Scholar
Favia, G, Lo Muzio, L, Serpico, R, Maiorano, E. Angiosarcoma of the head and neck with intra-oral presentation: a clinicopathological study of four cases. Oral Oncol 2002;38:757762.Google Scholar
Wenig, BM, Abbondanzo, SL, Heffess, CS. Epithelioid angiosarcoma of the adrenal glands: a clinicopathologic study of nine cases with a discussion of the implications of finding “epithelial-specific” markers. Am J Surg Pathol 1994;18:6273.Google Scholar
Taxy, JB, Battifora, H. Angiosarcoma of the gastrointestinal tract: a report of three cases. Cancer 1988;62:210216.Google Scholar
Allison, KH, Yoder, BJ, Bronner, MP, Goldblum, JR, Rubin, BP. Angiosarcoma involving the gastrointestinal tract: a series of primary and metastatic cases. Am J Surg Pathol 2004;28:298307.Google Scholar
McCaughey, WTE, Dardick, I, Barr, R. Angiosarcoma of serous membranes. Arch Pathol Lab Med 1983;107:304307.Google Scholar
Lin, BT, Colby, T, Gown, AM, et al. Malignant vascular tumors of the serous membranes mimicking mesothelioma: a report of 14 cases. Am J Surg Pathol 1996;20:14311439.Google Scholar
Zhang, PJ, Livolsi, VA, Brooks, JJ. Malignant epithelioid vascular tumors of the pleura: report of a series and literature review. Hum Pathol 2000;31:2934.Google Scholar
Del Frate, C, Mortele, K, Zanardi, R, et al. Pseudomesotheliomatous angiosarcoma of the chest wall and pleura. J Thorac Imaging 2003;18:200203.Google Scholar
Trassard, M, Le Doussal, V, Bui, BN, Coindre, JM. Angiosarcoma arising in a solitary schwannoma (neurilemmoma) of the sciatic nerve. Am J Surg Pathol 1996;20:14121417.Google Scholar
Mentzel, T, Katenkamp, D. Intraneural angiosarcoma and angiosarcoma arising in benign and malignant nerve sheath tumours: clinicopathological and immunohistochemical analysis of four cases. Histopathology 1999;35:114120.Google Scholar
Rückert, RI, Fleige, B, Rogalla, P, Woodruff, JM. Schwannoma with angiosarcoma: report of a case and comparison with other type of nerve sheath tumors with angiosarcoma. Cancer 2000;89:15771585.Google Scholar
McMenamin, ME, Fletcher, CD. Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma. A study of 17 cases. Am J Surg Pathol 2001;25:1325.Google Scholar
Lee, FY, Wen, MC, Wang, J. Epithelioid angiosarcoma arising in a deep-seated plexiform schwannoma: a case report and literature review. Hum Pathol 2007;38:10961101.Google Scholar
Macaulay, RA. Neurofibrosarcoma of the radial nerve in von Recklinghausen’s disease with metastatic angiosarcoma. J Neurol Neurosurg Psychiatry 1978;41:474478.Google Scholar
Millstein, DI, Tang, CK, Campvell, EW Jr. Angiosarcoma developing in a patient with neurofibromatosis (von Recklinghausen’s disease). Cancer 1981;47:950954.Google Scholar
Ducatman, BS, Scheithauer, BW. Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer 1984;54:10491057.Google Scholar
Riccardi, VM, Wheeler, TM, Pickard, LR, King, B. The pathophysiology of neurofibromatosis: II. Angiosarcoma as a complication. Cancer Genet Cytogenet 1984;12:275280.Google Scholar
Lederman, SM, Martin, EC, Laffey, KT, Lefkowitch, JH. Hepatic neurofibromatosis, malignant schwannoma, and angiosarcoma in von Recklinghause’s disease. Gastroenterology 1987;92:234239.Google Scholar
Brown, RW, Tornos, C, Evans, HL. Angiosarcoma arising from malignant schwannoma in a patient with neurofibromatosis. Cancer 1992;70:11411144.Google Scholar
Morphopoulos, GD, Banerjee, SS, Ali, HH, et al. Malignant peripheral nerve sheath tumour with vascular differentiation: a report of four cases. Histopathology 1996;28:401410.Google Scholar
Elli, M, Can, B, Ceyhan, M, et al. Intrathoracic malignant peripheral nerve sheath tumor with angiosarcoma in a child with NF1. Tumori 2007;93:641644.Google Scholar
Malagon, HD, Valdez, AM, Moran, CA, Suster, S. Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol 2007;31:13561362.Google Scholar
den Bakker, MA, Ansink, AC, Ewing-Graham, PC. “Cutaneous-type” angiosarcoma arising in a mature cystic teratoma of the ovary. J Clin Pathol 2006;59:658660.Google Scholar
Sahoo, S, Ryan, CW, Recant, WM, Yang, XJ. Angiosarcoma masquerading as embryonal carcinoma in the metastasis from a mature testicular teratoma. Arch Pathol Lab Med 2003;127:360363.Google Scholar
Nielsen, GP, Young, RH, Prat, J, Scully, RR. Primary angiosarcoma of the ovary: a report of seven cases and review of the literature. Int J Gynecol Pathol 1997;16:378382.Google Scholar
Jylling, AM, Jörgensen, L, Holund, B. Mucinous cystadenocarcinoma in combination with hemangiosarcoma in the ovary. Pathol Oncol Res 1999;5:318319.Google Scholar
Pillay, K, Essa, AS, Chetty, R. Borderline serous cystadenocarcinoma with coexistent angiosarcoma: an unusual form of ovarian carcinoma. Int J Surg Pathol 2001;9:317321.Google Scholar
Jennings, TA, Peterson, L, Axiotis, CA, et al. Angiosarcoma associated with foreign body material: a report of three cases. Cancer 1988;62:24362444.Google Scholar
Ben-Izhak, O, Kerner, H, Brenner, B, Lichtig, C. Angiosarcoma of the colon developing in a capsule of a foreign body: report of a case with associated hemorrhagic diathesis. Am J Clin Pathol 1992;97:416420.Google Scholar
Ben-Izhak, O, Vlodavsky, E, Ofer, A, et al. Epithelioid angiosarcoma associated with a Dacron vascular graft. Am J Surg Pathol 1999;23:14181422.Google Scholar
Cokelaere, K, Vanvuchelen, J, Michielsen, P, Sciot, R. Epithelioid angiosarcoma of the splenic capsule: report of a case reiterating the concept of inert foreign body tumorigenesis. Virchows Arch 2001;438:398403.Google Scholar
Folpe, Al, Johnston, CA, Weiss, SW. Cutaneous angiosarcoma arising in a gouty tophus: report of a unique case and review of foreign material-associated angiosarcomas. Am J Dermatopathol 2000;22:418421.Google Scholar
Lezama-del Valle, P, Gerald, WL, Tsai, J, Meyers, P, La Quaglia, MP. Malignant vascular tumors in young patients. Cancer 1998;83:16341639.Google Scholar
Ferrari, A, Casanova, M, Bisogno, G, et al. Malignant vascular tumors in children and adolescents: a report from the Italian and German Soft Tissue Sarcoma Cooperative Group. Med Pediatr Oncol 2002;39:109114.Google Scholar
Leake, J, Sheehan, MP, Rampling, D, Ramani, P, Atherton, DJ. Angiosarcoma complicating xeroderma pigmentosum. Histopathology 1992;21:179181.Google Scholar
Deyrup, AT, Miettinen, M, North, PE, et al. Pediatric cutaneous angiosarcomas: a clinicopathologic study of 10 cases. Am J Surg Pathol 2011;35:7075.Google Scholar
Deyrup, AT, Miettinen, M, North, PE, et al. Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol 2009;33:264269.Google Scholar
Kuzu, I, Bicknell, R, Harris, AL, et al. Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumours. J Clin Pathol 1992;45:143148.Google Scholar
Miettinen, M, Lindenmayer, AE, Chaubal, A. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens: evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand’s factor. Mod Pathol 1994;7:8290.Google Scholar
DeYoung, BR, Swanson, PE, Angenyi, ZB, et al. CD31 immunoreactivity in mesenchymal neoplasms of the skin and subcutis: report of 145 cases and review of putative immunohistologic markers of endothelial cell differentiation. J Cutan Pathol 1995;22:215222.Google Scholar
Traweek, ST, Kandalaft, P, Mehta, P, Battifora, H. The human progenitor cell antigen (CD34) in vascular neoplasia. Am J Clin Pathol 1991;96:2531.Google Scholar
Miettinen, M, Wang, ZF, Paetau, A, et al. ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma. Am J Surg Pathol 2011;35:432441.Google Scholar
Appleton, MA, Attanoos, RL, Jasani, B. Thrombomodulin as a marker of vascular and lymphatic tumours. Histopathology 1996;29:153157.Google Scholar
Partanen, TA, Alitalo, K, Miettinen, M. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors. Cancer 1999;86:24062412.Google Scholar
Itakura, E, Yamamoto, H, Oda, Y, Tsuneyoshi, M. Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas. J Surg Oncol 2008;97:7481.Google Scholar
Breiteneder-Geleff, S, Soleiman, A, Kowalski, H, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 1999;154:385394.Google Scholar
Kahn, HJ, Bailey, D, Marks, A. Monoclonal antibody D2–40, a new marker of lymphatic endothelium, reacts with Kaposi sarcoma and a subset of angiosarcomas. Mod Pathol 2002;15:434440.Google Scholar
Folpe, AL, Chand, EM, Goldblum, JR, Weiss, SW. Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics. Am J Surg Pathol 20001;25:10611066.Google Scholar
Miettinen, M, Fetsch, JF. Distribution of keratins in normal endothelial cells and in a spectrum of vascular tumors: implications in tumor diagnosis. Hum Pathol 2000;31:10621067.CrossRefGoogle Scholar
Al-Abbadi, MA, Almasri, NM, Al-Quran, S, Wilkinson, EJ. Cytokeratin and epithelial membrane antigen expression in angiosarcomas: an Immunohistochemical study of 33 cases. Arch Pathol Lab Med 2007;131:288292.Google Scholar
Miettinen, M, Lasota, J. KIT expression in angiosarcomas and in fetal endothelial cells: lack of c-kit mutations in exons 11 and 17 in angiosarcoma. Mod Pathol 2000;13:536541.CrossRefGoogle Scholar
Manner, J, Radlwimmer, B, Hohenberger, P, et al. MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema. Am J Pathol 2010;176:3439.Google Scholar
Guo, T, Zhang, L, Chang, NE, et al. Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. Genes Chromosomes Cancer 2011;50:2533.Google Scholar
Mentzel, T, Schildhaus, HU, Palmedo, G, Büttner, R, Kutzner, H. Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol 2012;25:7585.CrossRefGoogle ScholarPubMed
Fernandez, AP, Sun, Y, Tubbs, RR, Goldblum, JR, Billings, SD. FISH for MYC amplification and anti-MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations. J Cutan Pathol 2012;39:234242.Google Scholar
Shon, W, Sukov, WR, Jenkins, SM, Folpe, AL. MYC amplification and overexpression in primary cutaneous angiosarcoma: a fluorescence in-situ hybridization and immunohistochemical study. Mod Pathol 2014;27:509515.Google Scholar
Antonescu, CR, Yoshida, A, Guo, T, et al. KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors. Cancer Res 2009;69:71757179.Google Scholar
Behjati, S, Tarpey, PS, Sheldon, H, et al. Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat Genet 2014;46:376379.Google Scholar
Kindblom, LG, Stenman, G, Angervall, L. Morphological and cytogenetic studies of angiosarcoma in Stewart-Treves syndrome. Virchows Arch A Pathol Anat Histopathol 1991;419:439445.Google Scholar
Gill-Benso, R, Lopez-Gines, C, Soriano, P, et al. Cytogenetic study of angiosarcoma of the breast. Genes Chromosomes Cancer 1994;10:210212.Google Scholar
Schuborg, C, Mertens, F, Rydholm, A, et al. Cytogenetic analysis of four angiosarcomas from deep and superficial soft tissue. Cancer Genet Cytogenet 1998;100:5256.Google Scholar
Wong, KF, So, CC, Wong, N, et al. Sinonasal angiosarcoma with marrow involvement at presentation mimicking malignant lymphoma: cytogenetic analysis using multiple techniques. Cancer Genet Cytogenet 2001;129:6468.Google Scholar
Zu, Y, Pele, MA, Yan, Z, et al. Chromosomal abnormalities and p53 gene mutation in a cardiac angiosarcoma. Appl Immunohistochem Mol Morphol 2001;9:2428.Google Scholar
Oriel, JD. Moritz Kaposi (1837–1902). Int J STD AIDS 1997;8:715717.Google Scholar
Tappero, JW, Conant, MA, Wolfe, SF, Berger, TG. Kaposi’s sarcoma: epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy. J Am Acad Dermatol 1993;28:371395.Google Scholar
Uldrick, TS, Whitby, D. Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi Sarcoma. Cancer Lett 2011;305:150162.Google Scholar
Ganem, D. KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J Clin Invest 2010;120:939949.Google Scholar
Chang, Y, Cesarman, E, Pessin, MS, et al. Identification of herpes virus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994;266:18651869.Google Scholar
Moore, PJ, Chang, Y. Detection of Herpes virus-like DNA sequences in Kaposi’s sarcoma patients with and those without HIV-infection. N Engl J Med 1995;332:11811185.Google Scholar
Ambroziak, JA, Blackbourn, DJ, Herndier, BG, et al. Herpes-like sequences in HIV-infected and uninfected Kaposi’s sarcoma patients. Science 1995;268:582583.Google Scholar
Du, MQ, Bacon, CM, Isaacson, PG. Kaposi sarcoma-associated herpesvirus/ human herpesvirus 8 and lymphoproliferative disorders. J Clin Pathol 2007;60:13501357.Google Scholar
Duprez, R, Lacoste, V, Briere, J, et al. Evidence for a multifocal origin of multicentric advanced lesions of Kaposi sarcoma. J Natl Cancer Inst 2007;99:10861094.Google Scholar
Iscovich, J, Boffetta, P, Franceschi, S, Azizi, E, Sarid, R. Classic Kaposi sarcoma: epidemiology and risk factors. Cancer 2000;88:500517.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
Hiatt, KM, Nelson, AM, Lichy, J, Fanburg-Smith, JC. Classic Kaposi sarcoma in the United States over the last two decades: a clinicopathologic and molecular study of 438 non-HIV-related Kaposi sarcoma patients with comparison to HIV-related Kaposi sarcoma. Mod Pathol 2008;21:572582.Google Scholar
Gottlieb, GJ, Ackerman, AB. Kaposi’s sarcoma: an extensively disseminated form in young homosexual men. Hum Pathol 1982;13:882892.CrossRefGoogle ScholarPubMed
Niedt, GW, Myskowski, PL, Urmacher, C, et al. Histologic predictors of survival in acquired immunodeficiency syndrome-associated Kaposi’s sarcoma. Hum Pathol 1992;23:14191426.Google Scholar
Moskowitz, LB, Hensley, GT, Gould, EW, Weiss, SD. Frequency and anatomic distribution of lymphadenopathic Kaposi’s sarcoma in the acquired immunodeficiency syndrome. Hum Pathol 1985;16:447456.Google Scholar
Ioachim, HL, Adsay, V, Giancotti, FR, Dorsett, B, Melamed, J. Kaposi’s sarcoma of internal organs: a multiparameter study of 86 cases. Cancer 1995;75:13761385.Google Scholar
O’Connell, KM. Kaposi’s sarcoma: histopathological study of 159 cases from Malawi. J Clin Pathol 1977;30:687695.Google Scholar
Slavin, G, Cameron, HM, Forbes, C, Mitchell, RM. Kaposi’s sarcoma in East African children: a report of 51 cases. J Pathol 1970;100:198199.Google Scholar
Taylor, JF, Templeton, AC, Vogel, CL, Ziegler, JL, Kyalwazi, SK. Kaposi’s sarcoma in Uganda: a clinicopathological study. Int J Cancer 1971;8:122135.Google Scholar
Penn, I. Kaposi’s sarcoma in transplant recipients. Transplantation 1997;64:669673.Google Scholar
Farge, D, Lebbe, C, Marjanovic, Z, et al. Human herpes virus-8 and other risk factors for Kaposi’s sarcoma in kidney transplant recipients. Transplantation 1999;67:12361242.Google Scholar
Lebbé, C, Legendre, C, Francès, C. Kaposi sarcoma in transplantation. Transplant Rev (Orlando) 2008;22:252261.Google Scholar
Ackerman, AB. Subtle clues to diagnosis by conventional microscopy: the patch stage of Kaposi’s sarcoma. Am J Dermatopathol 1979;1:165172.Google Scholar
Radu, O, Pantanowitz, L. Kaposi sarcoma. Arch Pathol Lab Med 2013;137:289294.Google Scholar
Kao, G, Johnson, FB, Sulica, VI. The nature of hyaline (eosinophilic) globules and vascular slits in Kaposi’s sarcoma. Am J Dermatopathol 1990;12:256267.Google Scholar
Nickoloff, BJ. The human progenitor cell antigen (CD34) is localized on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferatin endothelial cells and stromal spindle-shaped cells in Kaposi’s sarcoma. Arch Dermatol 1991;127:523529.Google Scholar
Cheuk, W, Wong, KO, Wong, CS, et al. Immunostaining for human herpesvirus 8 latent nuclear antigen-1 helps distinguish Kaposi sarcoma from its mimickers. Am J Clin Pathol 2004;121:335342.Google Scholar
Patel, RM, Goldblum, JR, Hsi, ED. Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma. Mod Pathol 2004;17:456460.Google Scholar
Beckstead, JH, Wood, GS, Fletcher, V. Evidence for the origin of Kaposi’s sarcoma from lymphatic endothelium. Am J Pathol 1985;119;294300.Google ScholarPubMed
Jussila, L, Valtola, R, Partanen, TA, et al. Lymphatic endothelium and Kaposi’s sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3. Cancer Res 1998;58:15991604.Google Scholar
Weninger, WA, Partanen, TA, Breiteneder-Geleff, S, et al. Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi’s sarcoma tumor cells. Lab Invest 1999;79:243251.Google ScholarPubMed
McDonagh, DP, Liu, J, Gaffey, MJ, et al. Detection of Kaposi’s sarcoma-associated herpesvirus-like DNA sequence in angiosarcoma. Am J Pathol 1996;149:13631368.Google Scholar
Ishak, KG, Bijwaard, KE, Makhlouf, HR, et al. Absence of human herpesvirus 8 DNA sequences in vascular tumors of the liver. Liver 1998;18:124127.Google Scholar
Lasota, J, Miettinen, M. Absence of Kaposi’s sarcoma-associated virus (human herpesvirus-8) sequences in angiosarcoma. Virchows Arch 1999; 434:5156.Google Scholar
Schmid, H, Zietz, C. Human herpesvirus 8 and angiosarcoma: analysis of 40 cases and review of the literature. Pathology 2005;37:284287.Google Scholar
Haferkamp, O, Rosenau, W, Lennert, K. Vascular transformation of lymph node sinuses due to venous obstruction. Arch Pathol 1971;92:8183.Google Scholar
Cook, PD, Czerniak, B, Chan, JK, et al. Nodular spindle-cell vascular transformation of lymph nodes: a benign process occurring predominantly in retroperitoneal lymph nodes draining carcinomas that can simulate Kaposi’s sarcoma or metastatic tumor. Am J Surg Pathol 1995;19:10101020.Google Scholar
Chan, JK, Frizzera, G, Fletcher, CD, Rosai, J. Primary vascular tumors of the lymph nodes other than Kaposi’s sarcoma: analysis of 39 cases and delineation of two new entities. Am J Surg Pathol 1992;16:335358.Google Scholar

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