Book contents
- Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction
- Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction
- Copyright page
- Contents
- Contributors
- Foreword
- Chapter 1 In Vitro Fertilization and Micromanipulation
- Chapter 2 Development of ICSI in Human Assisted Reproduction
- Chapter 3 Current ICSI Applications and Clinical Outcomes
- Chapter 4 Rescue ICSI of IVF Failed-Fertilized Oocytes
- Chapter 5 Morphological Sperm Selection Before ICSI
- Chapter 6 Laser-Assisted ICSI
- Chapter 7 Piezo: The Add-On to Standardize ICSI Procedure
- Chapter 8 Artificial Oocyte Activation After ICSI
- Chapter 9 Health of Children Born after Intracytoplasmic Sperm Injections (ICSI)
- Chapter 10 Examining the Safety of ICSI Using Animal Models
- Chapter 11 Cellular and Molecular Events after ICSI in Clinically Relevant Animal Models
- Chapter 12 Micromanipulation, Micro-Injection Microscopes and Systems for ICSI
- Chapter 13 Automation Techniques and Systems for ICSI
- Chapter 14 Germline Nuclear Transfer Technology to Overcome Mitochondrial Diseases and Female Infertility
- Chapter 15 Nuclear Transfer Technology and Its Use in Reproductive Medicine
- Chapter 16 The Prospects of Infertility Treatment Using “Artificial” Eggs
- Index
- Plate Section (PDF Only)
- References
Chapter 1 - In Vitro Fertilization and Micromanipulation
The History That Changed the Treatment of Male Factor Infertility
Published online by Cambridge University Press: 02 December 2021
- Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction
- Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction
- Copyright page
- Contents
- Contributors
- Foreword
- Chapter 1 In Vitro Fertilization and Micromanipulation
- Chapter 2 Development of ICSI in Human Assisted Reproduction
- Chapter 3 Current ICSI Applications and Clinical Outcomes
- Chapter 4 Rescue ICSI of IVF Failed-Fertilized Oocytes
- Chapter 5 Morphological Sperm Selection Before ICSI
- Chapter 6 Laser-Assisted ICSI
- Chapter 7 Piezo: The Add-On to Standardize ICSI Procedure
- Chapter 8 Artificial Oocyte Activation After ICSI
- Chapter 9 Health of Children Born after Intracytoplasmic Sperm Injections (ICSI)
- Chapter 10 Examining the Safety of ICSI Using Animal Models
- Chapter 11 Cellular and Molecular Events after ICSI in Clinically Relevant Animal Models
- Chapter 12 Micromanipulation, Micro-Injection Microscopes and Systems for ICSI
- Chapter 13 Automation Techniques and Systems for ICSI
- Chapter 14 Germline Nuclear Transfer Technology to Overcome Mitochondrial Diseases and Female Infertility
- Chapter 15 Nuclear Transfer Technology and Its Use in Reproductive Medicine
- Chapter 16 The Prospects of Infertility Treatment Using “Artificial” Eggs
- Index
- Plate Section (PDF Only)
- References
Summary
This chapter reviews the short period between the exploration of male factor treatment using standard in vitro fertilization in small clinical series initiated in the early 1980s and subsequent development of micromanipulation technologies before ICSI. Instrumental fertilization was developed to improve the incidence of fertilization as well as apply the technology to patients with extreme male factor. A decade later, the Brussels team introduced ICSI, with fertilization rates that were at least twice as high compared to those of earlier micromanipulation approaches. A short history of male factor infertility and the biased views medical specialists showed in favor of solely treating the female partner is discussed in the context of discovery of gametes and the process of fertilization in the nineteenth century. The condition of infertility in men was basically considered untreatable until the 1970s, but as a clinical concept, it was also largely ignored. The possibility of using IVF for effectively treating less fertile men was considered experimental in 1980. The technical and physiological background as well as ambiguous animal models before clinical ICSI are evaluated particularly in the context of why early micromanipulation methods such as partial zona dissection and sub-zonal sperm insertion ultimately failed.
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- Manual of Intracytoplasmic Sperm Injection in Human Assisted ReproductionWith Other Advanced Micromanipulation Techniques to Edit the Genetic and Cytoplasmic Content of the Oocyte, pp. 1 - 10Publisher: Cambridge University PressPrint publication year: 2021