Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 A short history of latent inhibition research
- Current topics in latent inhibition research
- 2 Latent inhibition and extinction: their signature phenomena and the role of prediction error
- 3 Inter-stage context and time as determinants of latent inhibition
- 4 Latent inhibition: acquisition or performance deficit?
- 5 Latent inhibition and learned irrelevance in human contingency learning
- 6 Associative and nonassociative processes in latent inhibition: an elaboration of the Pearce–Hall model
- 7 From latent inhibition to retrospective revaluation: an attentional-associative model
- 8 Latent inhibition and habituation: evaluation of an associative analysis
- 9 Latent inhibition and creativity
- 10 The phylogenetic distribution of latent inhibition
- 11 The genetics of latent inhibition: studies of inbred and mutant mice
- 12 A comparison of mechanisms underlying the CS–US association and the CS–nothing association
- 13 The pharmacology of latent inhibition and its relevance to schizophrenia
- 14 Parahippocampal region–dopaminergic neuron relationships in latent inhibition
- 15 Latent inhibition and other salience modulation effects: same neural substrates?
- 16 What the brain teaches us about latent inhibition (LI): the neural substrates of the expression and prevention of LI
- 17 Latent inhibition in schizophrenia and schizotypy: a review of the empirical literature
- 18 A cautionary note about latent inhibition in schizophrenia: are we ignoring relevant information?
- 19 Latent inhibition as a function of anxiety and stress: implications for schizophrenia
- 20 Nicotinic modulation of attentional deficits in schizophrenia
- 21 Latent inhibition and schizophrenia: the ins and outs of context
- Summary and conclusions
- Index
- References
11 - The genetics of latent inhibition: studies of inbred and mutant mice
from Current topics in latent inhibition research
Published online by Cambridge University Press: 04 August 2010
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 A short history of latent inhibition research
- Current topics in latent inhibition research
- 2 Latent inhibition and extinction: their signature phenomena and the role of prediction error
- 3 Inter-stage context and time as determinants of latent inhibition
- 4 Latent inhibition: acquisition or performance deficit?
- 5 Latent inhibition and learned irrelevance in human contingency learning
- 6 Associative and nonassociative processes in latent inhibition: an elaboration of the Pearce–Hall model
- 7 From latent inhibition to retrospective revaluation: an attentional-associative model
- 8 Latent inhibition and habituation: evaluation of an associative analysis
- 9 Latent inhibition and creativity
- 10 The phylogenetic distribution of latent inhibition
- 11 The genetics of latent inhibition: studies of inbred and mutant mice
- 12 A comparison of mechanisms underlying the CS–US association and the CS–nothing association
- 13 The pharmacology of latent inhibition and its relevance to schizophrenia
- 14 Parahippocampal region–dopaminergic neuron relationships in latent inhibition
- 15 Latent inhibition and other salience modulation effects: same neural substrates?
- 16 What the brain teaches us about latent inhibition (LI): the neural substrates of the expression and prevention of LI
- 17 Latent inhibition in schizophrenia and schizotypy: a review of the empirical literature
- 18 A cautionary note about latent inhibition in schizophrenia: are we ignoring relevant information?
- 19 Latent inhibition as a function of anxiety and stress: implications for schizophrenia
- 20 Nicotinic modulation of attentional deficits in schizophrenia
- 21 Latent inhibition and schizophrenia: the ins and outs of context
- Summary and conclusions
- Index
- References
Summary
Latent inhibition (LI) refers to the phenomenon of reduced conditioning seen after nonreinforced stimulus preexposure. Animal studies of LI typically employ a between-subject procedure to demonstrate LI. In such procedures, one group of subjects is preexposed (PE) to the to-be-conditioned stimulus (CS), whereas another group of subjects is not preexposed (NPE). The CS is subsequently paired with an unconditioned stimulus (US). LI is measured by the difference in some index of learning (e.g., conditioned fear) of the CS–US association between the PE and NPE groups, and is manifested as poorer learning in the PE group. As detailed in several chapters in the present volume by Weiner, Lubow, Kumari and Ettinger, Escobar and Miller and others, a number of theories have been put forward to explain LI as a form of learned inattention in which subjects learn to ignore or reduce attention to irrelevant stimuli (Lubow,1989). LI has also been characterized as a form of proactive interference in which the inattentional response (acquired as a consequence of a “CS–no-consequence” association) interferes with, or competes for, the expression or retrieval of the conditioned response (resulting from an effective CS–US association) (Miller & Escobar, 2009; Weiner, 1990, 2003, 2009).
Deficits in attention and information processing are central features in schizophrenia, and these deficits may lead to stimulus overload, cognitive fragmentation and thought disorder common in this disorder (Freedman et al., 1991; Perry et al., 1999; Strauss et al., 1993).
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- Chapter
- Information
- Latent InhibitionCognition, Neuroscience and Applications to Schizophrenia, pp. 225 - 251Publisher: Cambridge University PressPrint publication year: 2010
References
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