Skip to main content Accessibility help
×
Hostname: page-component-745bb68f8f-l4dxg Total loading time: 0 Render date: 2025-01-09T21:26:59.885Z Has data issue: false hasContentIssue false

Chapter 57 - Clinical Neurophysiology in Movement Disorders

from Section 5: - Objectifying Movement Disorders

Published online by Cambridge University Press:  07 January 2025

Erik Ch. Wolters
Affiliation:
Universität Zürich
Christian R. Baumann
Affiliation:
Universität Zürich
Get access

Summary

Movement disorders arise from dysfunctional physiology within the motor and movement systems of the nervous system, and can involve multiple anatomic locations. A myriad of electrophysiologic manifestations can be detected in electromyography (EMG), electroencephalography (EEG), and other methods. Technical factors must be carefully considered and technical quality should be monitored throughout. Surface EMG provides the basis for the electrophysiologic examination of movement disorders. EEG is important for establishing cortical genesis as well as consciousness state determination during the movement disorder. Tremors of different etiologies may have different frequencies and activation characteristics that are best discovered on analysis of surface EMG characteristics. Also, classification of myoclonus physiology needs electrophysiologic testing. Proper myoclonus classification forms the best approach to symptomatic treatment strategy. Results from this testing provide important supplemental information, which can be used for a more exact diagnosis that leads to treatment.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2025

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Klassen, BT, Caviness, JN, Bower, JH. Electrophysiology testing of movement disorders. In: Rubin, DI, ed., Clinical Neurophysiology, fifth ed. Oxford: Oxford University Press; 2021: 845868.Google Scholar
Hallett, M, Shahani, BT, Young, RR. EMG analysis of stereotyped voluntary movements in man. J Neurol Neurosurg Psychiatry 1975;38:11541162.CrossRefGoogle ScholarPubMed
Berardelli, A, Dick, JP, Rothwell, JC, Day, BL, Marsden, CD. Scaling of the size of the first agonist EMG burst during rapid wrist movements in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 1986;49:12731279.CrossRefGoogle ScholarPubMed
Jahanshahi, M, Brown, RG, Marsen, CD. A comparative study of simple and choice reaction time in Parkinson’s, Huntington’s and cerebellar disease. J Neurol Neurosurg Psychiatry 1993;56:11691177.CrossRefGoogle ScholarPubMed
Benecke, R, Rothwell, JC, Dick, JP, Day, BL, Marsden, CD. Performance of simultaneous movements in patients with Parkinson’s disease. Brain 1986;109:739757.CrossRefGoogle ScholarPubMed
Benecke, R, Rothwell, JC, Dick, JP, Day, BL, Marsden, CD. Disturbance of sequential movements in patients with Parkinson’s disease. Brain 1987;110:361379.CrossRefGoogle ScholarPubMed
Benecke, R, Rothwell, JC, Dick, JP, Day, BL, Marsen, CD. Simple and complex movements off and on treatment in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 1987;50:296303.CrossRefGoogle ScholarPubMed
Brown, P, Corscos, DM, Rothwell, JC. Does parkinsonian action tremor contribute to muscle weakness in Parkinson’s disease? Brain 1997;120:401408.CrossRefGoogle ScholarPubMed
Brown, P, Corscos, DM, Rothwell, JC. Action tremor and weakness in Parkinson’s disease: a study of the elbow extensors. Mov Disord 1998;13:5660.CrossRefGoogle ScholarPubMed
Caviness, JN, Lue, L, Adler, CH, Walker, DG. Parkinson’s disease dementia and potential therapeutic strategies. CNS Neurosci Ther 2011;17:3244.CrossRefGoogle ScholarPubMed
Caviness, JN, Hentz, JG, Evidente, VGH, et al. Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson’s disease. Parkinsonism Rel Disord 2007;13:348354.CrossRefGoogle ScholarPubMed
Klassen, B, Hentz, J, Shill, H, et al. Quantitative electroencephalography as a predictor for Parkinson’s disease dementia. Neurology 2011;77:118124.CrossRefGoogle Scholar
Caviness, JN, Adler, CH, Beach, T, Wetjen, K, Caselli, RJ. Myoclonus in Lewy body disorders. Adv Neurol 2002;89:2330.Google ScholarPubMed
Caviness, JN, Lue, LF, Beach, TG, et al. Parkinson’s disease, cortical dysfunction, and alpha-synuclein. Mov Disord 2001;26:14361442.CrossRefGoogle Scholar
Mansur, PHG, Cury, LKP, Andrade, CAO, et al. A review on techniques for tremor recording and quantification. Crit Rev Biomed Eng 2007;35:343362.CrossRefGoogle ScholarPubMed
Deuschl, G, Bain, P, Brin, M. Consensus statement of the Movement Disorder Society on tremor. Ad Hoc Scientific Committee. Mov Disord 1998;13(S3):223.CrossRefGoogle Scholar
Sabra, AF, Hallett, M. Action tremor with alternating activity in antagonist muscles. Neurology 1984;34:151156.CrossRefGoogle ScholarPubMed
Milanov, I. Clinical and electromyographic examinations of patients with essential tremor. Can J Neurol Sci 2000;27:6570.CrossRefGoogle ScholarPubMed
Caviness, JN, Adler, CH, Hentz, JG, et al. Electrophysiological biomarkers of incidental Lewy body disease. Clin Neurophysiol 2011;122:24262432.CrossRefGoogle Scholar
Heilman, KM. Orthostatic tremor. Arch Neurol 1984;41:880881.CrossRefGoogle ScholarPubMed
Glass, GA, Ahlskog, JE, Matsumoto, JY. Orthostatic myoclonus: a contributor to gait decline in selected elderly. Neurology 2007;68:18261830.CrossRefGoogle ScholarPubMed
Rigby, HB, Rigby, MH, Caviness, JN. Orthostatic tremor: a spectrum of fast and slow frequencies or distinct entities? Tremor Other Hyperkinet Mov (N Y) 2015;5:324.CrossRefGoogle ScholarPubMed
Kamble, NL, Pal, PK. Electrophysiological evaluation of psychogenic movement disorders. Parkinsonism Relat Disord 2016;22:S153S158.CrossRefGoogle ScholarPubMed
Caviness, JN, Brown, P. Myoclonus: current concepts and recent advances. Lancet Neurol 2004;3:598607.CrossRefGoogle ScholarPubMed
Marsden, CD, Hallett, M, Fahn, S. The nosology and pathophysiology of myoclonus. In: Marsden, CD, Fahn, S, eds., Movement Disorders. Oxford: Butterworths; 1982: 196248.Google Scholar
Pena, AB, Caviness, JN. Physiology-based treatment of myoclonus. Neurotherapeutics 2020;17:16651680.CrossRefGoogle ScholarPubMed
Caviness, JN. Clinical neurophysiology of myoclonus. In: Hallett, M, ed., Handbook of Clinical Neurophysiology. Oxford: Elsevier; 2003: 521548.CrossRefGoogle Scholar
Zutt, R, Elting, JW, van Zijl, JC, et al. Electrophysiologic testing aids diagnosis and subtyping of myoclonus. Neurology 2018;90(8):e647e657.CrossRefGoogle ScholarPubMed
Shibasaki, H. Electrophysiologic studies of myoclonus. AAEE Minimonograph 30. Muscle Nerve 2000;23:321335.3.0.CO;2-3>CrossRefGoogle Scholar
Caviness, JN, Kurth, M. Cortical myoclonus in Huntington’s disease associated with an enlarged somatosensory evoked potential. Mov Disord 1997;12:10461051.CrossRefGoogle ScholarPubMed
Caviness, JN. Epileptic myoclonus. In: Sirven, JI, Stern, JM, eds., Atlas of Video-EEG Monitoring. New York: McGraw-Hill Medical; 2011: 309328.Google Scholar
Guerrini, R, Bonanni, P, Parmeggiani, L, et al. Pathophysiology of myoclonic epilepsies. Adv Neurol 2005;95:2346.Google ScholarPubMed
Roze, E, Apartis, E, Clot, F, et al. Myoclonus-dystonia: clinical and electrophysiologic pattern related to SGCE mutations. Neurology 2008;70:10101016.CrossRefGoogle ScholarPubMed
Hallett, M, Chadwick, D, Adam, J, Marsden, CD. Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus. J Neurol Neurosurg Psychiatry 1977;40:253264.CrossRefGoogle ScholarPubMed
Caviness, JN, Forsyth, PJ, McPhee, T, Layton, DD. The movement disorder syndrome of adult opsoclonus. Mov Disord 1995;10:2227.CrossRefGoogle ScholarPubMed
Gwinn, KA, Caviness, JN. Electrophysiological observations in idiopathic opsoclonus–myoclonus syndrome. Mov Disord 1997;12:438442.CrossRefGoogle ScholarPubMed
Brown, P, Thompson, PD, Rothwell, JC, Day, BL, Marsden, CD. Axial myoclonus of propriospinal origin. Brain 1991;114:197214.Google ScholarPubMed
Roze, E, Bounolleau, P, Ducreux, D, et al. Propriospinal myoclonus revisited: clinical, neurophysiologic, and neuroradiologic findings. Neurology 2009;72:13011309.CrossRefGoogle ScholarPubMed
Caviness, JN. Segmental myoclonus. In: Albanese, A, Jankovic, J, eds., Hyperkinetic Movement Disorders: Differential Diagnosis and Treatment. Oxford: Wiley-Blackwell; 2012: 221235.Google Scholar
Westmoreland, BF, Sharbrough, FW, Stockard, JJ, et al. Brainstem auditory evoked potentials in 20 patients with palatal myoclonus. Arch Neurol 1983;40:155158.CrossRefGoogle ScholarPubMed
Deuschl, G, Toro, C, Valls-Sole, J, et al. Symptomatic and essential palatal tremor. 1. Clinical, physiological and MRI analysis. Brain 1994;117:775788.CrossRefGoogle ScholarPubMed
Calancie, B. Spinal myoclonus after spinal cord injury. J Spinal Cord Med 2006;29:413424.CrossRefGoogle ScholarPubMed
Brown, P, Thompson, PD. Electrophysiological aids to the diagnosis of psychogenic jerks, spasms, and tremor. Mov Disord 2001;16:595599.CrossRefGoogle Scholar
Van der Salm, M, Tijssen, MAJ, Kowlman, JHTM, van Rootselaar, AF. The bereitschaftspotential in jerky movement disorders. J Neurol Neurosurg Psychiatry 2012;83:11621167.CrossRefGoogle ScholarPubMed
Brown, P, Rothwell, JC, Thompson, PD, et al. New observations on the normal auditory startle reflex in man. Brain 1991;114;18911902.CrossRefGoogle ScholarPubMed
Wilkins, DE, Hallett, M, Wess, MM. Audiogenic startle reflex of man and its relationship to startle syndromes. A review. Brain 1986;109:561573.CrossRefGoogle ScholarPubMed
Grigoriu, AI, Dinomais, M, Remy-Neris, O, Brochard, S. Impact of injection-guiding techniques on the effectiveness of botulinum toxin for the treatment of focal spasticity and dystonia: a systematic review. Arch Phys Med Rehabil 2015;96:20672078.CrossRefGoogle ScholarPubMed
Yianni, J, Yan Wang, S, Liu, X, et al. A dominant bursting electromyography pattern in dystonic conditions predicts an early response to pallidal stimulation. J Clin Neurosci 2006;13:738746.CrossRefGoogle Scholar
Deuschl, G, Heinen, F, Kleedorfer, B, et al. Clinical and polymyographic investigation of spasmodic torticollis. J Neurol 1992;239:915.CrossRefGoogle ScholarPubMed
Caviness, JN. Clinical neurophysiology. In: Wolters, ECh, Baumann, CR, eds., Movement Disorders. Parkinson Disease and Other Movement Disorders. Amsterdam: VU University Press; 2014: 771787.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×