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Chapter 9 - Psychiatric Causes of Agitation: Exacerbation of Mood and Psychotic Disorders

Published online by Cambridge University Press:  09 March 2017

By
Marina Garriga ,
Isabella Pacchiarotti ,
Miquel Bernardo  and
Eduard Vieta
Edited by
Scott L. Zeller ,
Kimberly D. Nordstrom  and
Michael P. Wilson
Scott L. Zeller
Affiliation:
University of California, Riverside
Kimberly D. Nordstrom
Affiliation:
Denver Health Medical Center, Colorado
Michael P. Wilson
Affiliation:
University of California, San Diego
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The Diagnosis and Management of Agitation , pp. 126 - 143
Publisher: Cambridge University Press
Print publication year: 2017

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References

Advokat, C. (2010). A brief overview of iatrogenic akathisia. Clin Schizophr Relat Psychoses. 3, 226–236.CrossRefGoogle Scholar
Alderfer, B. S., Allen, M. H. (2003). Treatment of agitation in bipolar disorder across the life cycle. J Clin Psychiatry. 64 Suppl 4, 3–9.Google ScholarPubMed
Allen, M. H., Currier, G. W., Carpenter, D., Ross, R. W., Docherty, J. P. (2005). The expert consensus guideline series. Treatment of behavioral emergencies 2005. J Psychiatr Pract. 11 (Suppl 1), 5–108, quiz 110–112.CrossRefGoogle ScholarPubMed
Allen, M. H., Currier, G. W., Hughes, D. H., Docherty, J. P., Carpenter, D., Ross, R. (2003). Treatment of behavioral emergencies: a summary of the expert consensus guidelines. J Psychiatr Pract. 9, 16–38.CrossRefGoogle ScholarPubMed
Allen, M. H., Currier, G. W., Hughes, D. H., Reyes-Harde, M., Docherty, J. P. (2001). The Expert Consensus Guideline Series. Treatment of behavioral emergencies. Postgrad Med. (Spec No), 1–88, quiz 89–90.Google Scholar
American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. American Psychiatric Publishing, Inc. Available at: http://dx.doi.org/10.1176/appi.books.9780890425596 (Accessed May 13, 2016).Google Scholar
Angst, J., Gamma, A., Benazzi, F., Ajdacic, V., Rössler, W. (2009). Does psychomotor agitation in major depressive episodes indicate bipolarity? Evidence from the Zurich Study. Eur Arch Psychiatry Clin Neurosci. 259, 55–63.CrossRefGoogle ScholarPubMed
Battaglia, J. Pharmacological management of acute agitation. Drugs (2005 Jan). [cited 2014 Nov 25]; 65(9):1207–22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15916448.CrossRefGoogle ScholarPubMed
Baker, S. N. (2012) Management of acute agitation in the emergency department. Adv Emerg Nurs J. 34, 306–18, quiz 319–320.CrossRefGoogle ScholarPubMed
Buckley, P., Citrome, L., Nichita, C., Vitacco, M. (2011). Psychopharmacology of aggression in schizophrenia. Schizophr Bull. 37, 930–936.CrossRefGoogle ScholarPubMed
Citrome, L. (2002). Atypical antipsychotics for acute agitation. New intramuscular options offer advantages. Postgrad Med. 112, 85–8, 94–6.CrossRefGoogle ScholarPubMed
Citrome, L., Krakowski, M., Greenberg, W. M., Andrade, E., Volavka, J. (2001). Antiaggressive effect of quetiapine in a patient with schizoaffective disorder. J Clin Psychiatry. 62, 901.CrossRefGoogle Scholar
Citrome, L., Volavka, J. (2011). Pharmacological management of acute and persistent aggression in forensic psychiatry settings. CNS Drugs. 25, 1009–1021.CrossRefGoogle ScholarPubMed
Citrome, L., Volavka, J. (2014). The psychopharmacology of violence: making sensible decisions. CNS Spectr. 19, 411–418.CrossRefGoogle ScholarPubMed
Cohen-Mansfield, J., Werner, P., Marx, M. S. (1989). An observational study of agitation in agitated nursing home residents. Int Psychogeriatr. 1, 153–165.CrossRefGoogle ScholarPubMed
Coid, J. W., Ullrich, S., Kallis, C., et al. (2013). The relationship between delusions and violence: findings from the East London first episode psychosis study. JAMA Psychiatry. 70, 465–471.CrossRefGoogle ScholarPubMed
Cornaggia, C. M., Beghi, M., Pavone, F., Barale, F. (2011). Aggression in psychiatry wards: a systematic review. Psychiatry Res. 189, 10–20.CrossRefGoogle ScholarPubMed
Fazel, S., Gulati, G., Linsell, L., Geddes, J. R., Grann, M. (2009). Schizophrenia and violence: systematic review and meta-analysis. PLoS Med. 6: e1000120.CrossRefGoogle ScholarPubMed
Fisher, W. A. (1994). Restraint and seclusion: a review of the literature. Am J Psychiatry. 151, 1584–1591.Google ScholarPubMed
Fishkind, A. Calming agitation with words, not drugs: 10 commandments for safety. Current Psych. Philadelphia: PA: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2002;1(4).Google Scholar
Garriga, M., Pacchiarotti, I., Kasper, S., et al. (2016). Assessment and management of agitation in psychiatry: expert consensus. World J Biol Psychiatry. 17, 86–128.CrossRefGoogle ScholarPubMed
Hankin, C., Bronstone, A., Koran, L. (2011). Agitation in the inpatient psychiatric setting: a review of clinical presentation, burden, and treatment. J Psychiatr Pract. 17, 170–185.CrossRefGoogle ScholarPubMed
Hasan, A., Falkai, P., Wobrock, T., et al. (2012). World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance. World J Biol Psychiatry. 13, 318–378.CrossRefGoogle ScholarPubMed
Huber, C. G., Lambert, M., Naber, D., et al. (2008). Validation of a Clinical Global Impression Scale for Aggression (CGI-A) in a sample of 558 psychiatric patients. Schizophr Res. 100, 342–348.CrossRefGoogle Scholar
Huf, G., Alexander, J., Allen, M. H. (2005). Haloperidol plus promethazine for psychosis induced aggression. Cochrane Database Syst Rev. (1), CD005146.Google ScholarPubMed
Iwanami, T., Maeshima, H., Baba, H., et al. (2015). Psychomotor agitation in major depressive disorder is a predictive factor of mood-switching. J Affect Disord. 170, 185–189.CrossRefGoogle ScholarPubMed
Jarema, M. R. (2015). Leczenie pacjentów pobudzonych. In: Medica, V, editor. Standardy leczenia farmakologicznego niektórych zaburzeń psychicznych. Gdańsk. 49–51.Google Scholar
Kasper, S., Baranyi, A., Eisenburger, P., et al. (2013). Die Behandlung der Agitation beim psychiatrischen Notfall. Konsensus-Statement – State of the art 2013. Clin Neuropsy Sonderausgabe. 1–15.Google Scholar
Kay, S. R., Fiszbein, A., Opler, L. A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia bulletin (1987 Jan) [cited 2014 Nov 10];13(2):261–76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3616518.CrossRefGoogle ScholarPubMed
Knox, D. K., Holloman, G. H. (2012). Use and avoidance of seclusion and restraint: consensus statement of the American Association for Emergency Psychiatry Project BETA seclusion and restraint workgroup. West J Emerg Med. 13, 35–40.CrossRefGoogle Scholar
Krakowski, M., Czobor, P. (1997). Violence in psychiatric patients: the role of psychosis, frontal lobe impairment, and ward turmoil. Compr Psychiatry. 38, 230–236.CrossRefGoogle Scholar
Linaker, O. M., Busch-Iversen, H. Predictors of imminent violence in psychiatric inpatients. Acta psychiatrica Scandinavica [Internet]. 1995 Oct [cited 2014 Nov 26];92(4):250–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8848948.CrossRefGoogle ScholarPubMed
Lindenmayer, J. P. (2000). The pathophysiology of agitation. J Clin Psychiatry. 61 Suppl 1, 5–10.Google ScholarPubMed
Marder, S. R. (2006). A review of agitation in mental illness: treatment guidelines and current therapies. J Clin Psychiatry. 67 Suppl 1, 13–21.Google ScholarPubMed
McNiel, D. E., Binder, R. L. (1994). The relationship between acute psychiatric symptoms, diagnosis, and short-term risk of violence. Hosp Community Psychiatry. 45, 133–137.Google ScholarPubMed
Mohr, W. K., Petti, T. A., Mohr, B. D. (2003). Adverse effects associated with physical restraint. Can J Psychiatry. 48, 330–337.CrossRefGoogle ScholarPubMed
Nelson, R. J., Trainor, B. C. (2007). Neural mechanisms of aggression. Nat Rev Neurosci. 8, 536–46.CrossRefGoogle ScholarPubMed
Ng, A. T., Zeller, S. L., Rhoades, R. W. (2010). Clinical challenges in the pharmacologic management of agitation. Prim Psychiatry. 17, 46–52.Google Scholar
Noble, P., Rodger, S. (1989). Violence by psychiatric in-patients. Br J Psychiatry. 155, 384–390.CrossRefGoogle ScholarPubMed
Nolan, K. A., Volavka, J., Czobor, P., et al. (2005). Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder. J Psychiatr Res. 39, 109–115.CrossRefGoogle ScholarPubMed
Nordstrom, K., Allen, M. H. (2007). Managing the acutely agitated and psychotic patient. CNS Spectr [Internet]. 12(10 Suppl 17), 5–11.CrossRefGoogle ScholarPubMed
Nordstrom, K., Zun, L. S., Wilson, M. P., et al. (2012). Medical evaluation and triage of the agitated patient: consensus statement of the American Association for Emergency Psychiatry Project BETA Medical Evaluation Workgroup. West J Emerg Med [Internet]. 13, 3–10.CrossRefGoogle Scholar
Nourse, R., Reade, C., Stoltzfus, J., Mittal, V. (2014). Demographics, clinical characteristics, and treatment of aggressive patients admitted to the acute behavioral unit of a community general hospital: a prospective observational study. Prim Care Companion CNS Disord. 16.CrossRefGoogle Scholar
Osser, D. N., Sigadel, R. (2001). Short-term inpatient pharmacotherapy of schizophrenia. Harv Rev Psychiatry. 9, 89–104.CrossRefGoogle ScholarPubMed
Pacchiarotti, I., Bond, D. J., Baldessarini, R. J., et al. (2013). The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. Am J Psychiatry. 170, 1249–1262.CrossRefGoogle ScholarPubMed
Palmstierna, T., Wistedt, B. (1987). Staff observation aggression scale, SOAS: presentation and evaluation. Acta Psychiatr Scand. 76, 657–663.CrossRefGoogle ScholarPubMed
Peiró, S., Gómez, G., Navarro, M., et al. (2004). Length of stay and antipsychotic treatment costs of patients with acute psychosis admitted to hospital in Spain. Description and associated factors. The Psychosp study. Soc Psychiatry Psychiatr Epidemiol. 39, 507–513.CrossRefGoogle ScholarPubMed
Perugi, G., Akiskal, H. S., Micheli, C., Toni, C., Madaro, D. (2001). Clinical characterization of depressive mixed state in bipolar-I patients: Pisa-San Diego collaboration. J Affect Disord. [Internet]. 67, 105–114.CrossRefGoogle Scholar
Perugi, G., Angst, J., Azorin, J. M., et al. (2015). Mixed features in patients with a major depressive episode: the BRIDGE-II-MIX study. J Clin Psychiatry. 76, e351–8.CrossRefGoogle Scholar
Petit, J. R. (2005). Management of the acutely violent patient. Psychiatr Clin North Am 28, 701–711, 710.CrossRefGoogle ScholarPubMed
Piechniczek-Buczek, J. (2006). Psychiatric emergencies in the elderly population. Emerg Med Clin North Am. 24, 467–490, viii.CrossRefGoogle ScholarPubMed
Pilowsky, L. S., Ring, H., Shine, P. J., Battersby, M., Lader, M. (1992). Rapid tranquillisation. A survey of emergency prescribing in a general psychiatric hospital. Br J Psychiatry. 160, 831–835.CrossRefGoogle Scholar
Popovic, D., Vieta, E., Azorin, J. M., et al. (2015). Suicide attempts in major depressive episode: evidence from the BRIDGE-II-Mix study. Bipolar Disord. 17, 795–803.CrossRefGoogle ScholarPubMed
Pratts, M., Citrome, L., Grant, W., Leso, L., Opler, L. A. (2014). A single-dose, randomized, double-blind, placebo-controlled trial of sublingual asenapine for acute agitation. Acta psychiatrica Scandinavica [Internet]. 2014 Jul [cited 2015 Jan 21];130(1):61–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24606117CrossRefGoogle ScholarPubMed
Ribeiro, J. D., Bender, T. W., Selby, E. A., Hames, J. L., Joiner, T. E. (2011). Development and validation of a brief self-report measure of agitation: the Brief Agitation Measure. J Pers Assess. 93, 597–604.CrossRefGoogle ScholarPubMed
Richmond, J. S., Berlin, J. S., Fishkind, A. B., et al. (2012). Verbal de-escalation of the agitated patient: consensus statement of the American Association for Emergency Psychiatry Project BETA De-escalation Workgroup. West J Emerg Med. 13, 17–25.CrossRefGoogle Scholar
Rosell, D. R., Siever, L. J. (2015). The neurobiology of aggression and violence. CNS Spectr. 20, 254–279.CrossRefGoogle ScholarPubMed
Sani, G., Tondo, L., Koukopoulos, A., Reginaldi, D., Kotzalidis, G. Dk, Koukopoulos, A. E., et al. Suicide in a large population of former psychiatric inpatients. Psychiatry and clinical neurosciences [Internet]. 2011 Apr; 65(3):286–295. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21507136.CrossRefGoogle Scholar
Schleifer, J. J. Management of acute agitation in psychosis: an evidence-based approach in the USA. Advances in Psychiatric Treatment [Internet]. 2011 Feb 28 [cited 2014 Nov 21];17(2):91–100. Available from: http://apt.rcpsych.org/cgi/doi/10.1192/apt.bp.109.007310CrossRefGoogle Scholar
Shim, I. H., Woo, Y. S., Jun, T. Y, Bahk, W. M. (2014). Mixed-state bipolar I and II depression: time to remission and clinical characteristics. J Affect Disord. 152–154, 340–346.CrossRefGoogle ScholarPubMed
Siever, L. J. (2008). Neurobiology of aggression and violence. Am J Psychiatry. 165, 429–442.CrossRefGoogle ScholarPubMed
Silver, J. M., Yudofsky, S. C. (1991). The Overt Aggression Scale: overview and guiding principles. J Neuropsychiatry Clin Neurosci. 3, S22–9.Google ScholarPubMed
Soyka, M. (2002). Aggression in schizophrenia: assessment and prevalence. Br J Psychiatry. 80, 278–279.CrossRefGoogle Scholar
Stevenson, S., Otto, M. P. (1998). Finding ways to reduce violence in psychiatric hospitals. J Healthc Qual. 20, 28–32.CrossRefGoogle ScholarPubMed
Stowell, K. R., Florence, P., Harman, H. J., Glick, R. L. (2012). Psychiatric evaluation of the agitated patient: consensus statement of the American Association for Emergency Psychiatry Project BETA Psychiatric Evaluation Workgroup. West J Emerg Med. 13, 11–16.CrossRefGoogle Scholar
Strout, T. D. (2014). Psychometric testing of the Agitation Severity Scale for acute presentation behavioral management patients in the emergency department. Adv Emerg Nurs J. 36, 250–270.CrossRefGoogle ScholarPubMed
Swann, A. C. (2013). Activated depression: mixed bipolar disorder or agitated unipolar depression? Curr Psychiatry Rep. 15, 376.CrossRefGoogle ScholarPubMed
Swanson, J. W., Swartz, M. S., Van Dorn, R. A., et al. (2006). A national study of violent behavior in persons with schizophrenia. Arch Gen Psychiatry. 63, 490–499.CrossRefGoogle ScholarPubMed
Swift, R. H., Harrigan, E. P., Cappelleri, J. C., Kramer, D., Chandler, L. P. (2002). Validation of the behavioral activity rating scale (BARS): a novel measure of activity in agitated patients. J Psychiatr Res. 36, 87–95.CrossRefGoogle Scholar
Vassos, E., Collier, D. A., Fazel, S. (2014). Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression. Mol Psychiatry. 19, 471–477.CrossRefGoogle ScholarPubMed
Vieta, E., Grunze, H., Azorin, J. M., Fagiolini, A. (2014). Phenomenology of manic episodes according to the presence or absence of depressive features as defined in DSM-5: Results from the IMPACT self-reported online survey. J Affect Disord. 156, 206–213.CrossRefGoogle ScholarPubMed
Vieta, E., Valentí, M. (2013). Pharmacological management of bipolar depression: acute treatment, maintenance, and prophylaxis. CNS Drugs. 27, 515–529.CrossRefGoogle ScholarPubMed
Volavka, J., Citrome, L. (2011). Pathways to aggression in schizophrenia affect results of treatment. Schizophr Bull. 37, 921–929.CrossRefGoogle ScholarPubMed
Volavka, J., Czobor, P., Citrome, L., Van Dorn, R. A. (2014). Effectiveness of antipsychotic drugs against hostility in patients with schizophrenia in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study. CNS Spectr. 19, 374–381.CrossRefGoogle ScholarPubMed
Warnke, I., Rössler, W., Herwig, U. (2011). Does psychopathology at admission predict the length of inpatient stay in psychiatry? Implications for financing psychiatric services. BMC Psychiatry. 11, 120.CrossRefGoogle ScholarPubMed
Webster, C., Douglas, K., Eaves, D., Hart, S. (1997). HCR-20: Assessing the Risk for Violence (Version 2). Vancouver: Mental Health, Law, and Policy Institute, Simon Fraser University.Google Scholar
Yildiz, A., Sachs, G. S., Turgay, A. (2003). Pharmacological management of agitation in emergency settings. Emerg Med J. 20, 339–346.CrossRefGoogle ScholarPubMed
Yudofsky, S. C., Silver, J. M., Jackson, W., Endicott, J., Williams, D. (1986). The Overt Aggression Scale for the objective rating of verbal and physical aggression. Am J Psychiatry. 143, 35–39.Google ScholarPubMed
Zeller, S. L., Citrome, L. (2016). Managing agitation associated with schizophrenia and bipolar disorder in the emergency setting. West J Emerg Med. 17, 165–172.CrossRefGoogle ScholarPubMed
Zeller, S. L., Rhoades, R. W. (2010). Systematic reviews of assessment measures and pharmacologic treatments for agitation. Clin Ther. 32, 403–425.CrossRefGoogle ScholarPubMed
Zimbroff, D. L., Marcus, R. N., Manos, G., et al. (2007). Management of acute agitation in patients with bipolar disorder: efficacy and safety of intramuscular aripiprazole. J Clin Psychopharmacol. 27, 171–176.CrossRefGoogle ScholarPubMed

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