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Chapter 24 - When Amoxicillin Just Doesn’t Cover It

Published online by Cambridge University Press:  17 December 2021

By
Michael Carter  and
Marilyn McDougall
Edited by
Shelley Riphagen  and
Sam Fosker
Shelley Riphagen
Affiliation:
Evelina Children’s Hospital, London and South Thames Retrieval Service
Sam Fosker
Affiliation:
Evelina Children’s Hospital, London
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Summary

A previously healthy 15-year-old boy presented to his local A&E with a 24-hour history of cough, sore throat and difficulty in breathing. He had seen his GP that morning, who had prescribed a short course of oral amoxicillin. He had taken his first dose of amoxicillin 2 hours before presentation to the A&E and subsequently became progressively tachypnoeic and tachycardic, with some suggestion his lips looked more swollen.

Type
Chapter
Information
Cases in Paediatric Critical Care Transfer and Retrieval Medicine , pp. 127 - 134
Publisher: Cambridge University Press
Print publication year: 2022

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References

Further Reading

Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301–8.Google Scholar
ARDS Definition Task Force, Ranieri, VM, Rubenfeld, GD, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012;307, 2526–33, .Google ScholarPubMed
Briel, M, Meade, M, Mercat, A, et al. Higher vs lower positive end-experiatory pressure in patients with acute lung injury and acute respiratory distress syndrome. JAMA 2010;303: 865–73.CrossRefGoogle Scholar
Combes, A, Hajage, D, Capellier, D, et al. Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. N Engl J Med 2018;378:1965–75.CrossRefGoogle ScholarPubMed
Goldstein, ., Giroir, ., Randolp, A, & International Consensus Conference on Pediatric, S. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005;6:2–8, doi:10.1097/01.PCC.0000149131.72248.E6.CrossRefGoogle ScholarPubMed
Goligher, EC, Tomlinson, G, Hajage, D, et al. Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc Bayesian analysis of a randomized clinical trial. JAMA 2018;320:2251–9.CrossRefGoogle Scholar
Griffiths, MJD, McAuley, DF, Perkins, GD, et al. Guidelines on the management of acute respiratory distress syndrome. BMJ Open Respir Res 2019;6:e000420.CrossRefGoogle ScholarPubMed
Khemani, RG, Smith, L, Lopez-Fernandez, YM, et al. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. Lancet Resp Med 2019;7:115–28.Google ScholarPubMed
Levy, MM, Fink, MP, Marshall, JC, et al. SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2001;29: 530–8, doi:10.1007/s00134-003-1662-x.Google Scholar
Maitland, K, Kiguli, S, Opoka, RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med 2011;364:2483–95.CrossRefGoogle ScholarPubMed
Matics, TJ, Sanchez-Pinto, LN. Adaptation and validation of a Pediatric Sequential Organ Failure Assessment Score and evaluation of the Sepsis-3 definitions in critically ill children. JAMA Pediatr 2017;171:e172352.CrossRefGoogle ScholarPubMed
National Institute for Health and Clinical Excellence (NICE). Sepsis: recognition, diagnosis and early management (NG51). (NICE, London, 2016).Google Scholar
Obonyo, NG, Schlapbach, LJ, Fraser, JF. Sepsis: changing definitions, unchanging treatment. Front Pediatr 2018; 425.Google ScholarPubMed
Pediatric Acute Lung Injury Consensus Conference Group. Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med 16, 428–39, doi:10.1097/PCC.00000000000003502015.Google Scholar
Raith, EP, Udy, AA, Bailey, M, et al.Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit. JAMA 2017;317:290–300.CrossRefGoogle ScholarPubMed
Schlapbach, LJ, Straney, L, Bellomo, R, et al. Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit. Intensive Care Med 2018;44:179–88.CrossRefGoogle ScholarPubMed
Sepsis Trust. The UK Sepsis Trust: Clinical Tools, https://sepsistrust.org/professional-resources/clinical-tools/ (2020).Google Scholar
Shankar-Hari, M, Harrison, DA, Rowan, K M. Differences in impact of definitional elements on mortality precludes international comparisons of sepsis epidemiology-a cohort study illustrating the need for standardized reporting. Crit Care Med 2016;44:2223–30, doi:10.1097/CCM.0000000000001876CrossRefGoogle ScholarPubMed
Shankar-Hari, M, Harrison, DA, Rubenfeld, GD, Rowan, K. Epidemiology of sepsis and septic shock in critical care units: comparison between sepsis-2 and sepsis-3 populations using a national critical care database. Br J Anaesth 2017;119:62636.CrossRefGoogle ScholarPubMed
Shankar-Hari, M. Phillips, GS, Levy, ML, et al. Developing a new definition and assessing new clinical criteria for septic shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016;315:775–87, doi:10.1001/jama.2016.0289.CrossRefGoogle ScholarPubMed
Singer, M, Deutschman, CS, Seymour, CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016;315:801–10.CrossRefGoogle ScholarPubMed
South Thames Retrieval Service. 2020 Clinical Guidance. Paediatric Critical Care: Acute Respiratory Distress Syndrome(ARDS). (www.evelinalondon.nhs.uk/resources/our-services/hospital/south-thames-retrieval-service/acute-respiratory.pdf, 2019).Google Scholar
Weiss, SL, Peter, MJ, Alhazzani, W, et al. Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med 2018;21:52–e106.CrossRefGoogle Scholar
Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial, I. et al. Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: A Randomized Clinical Trial. JAMA 2017;318:1335–45.Google Scholar

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