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Chapter 19 - Fertility considerations and methods of fertility preservation in patients undergoing treatment for cancer

from Section 3 - Management of maternal complications during treatment

Published online by Cambridge University Press:  05 December 2011

By
Avi Leader
Edited by
Gideon Koren  and
Michael Lishner
Gideon Koren
Affiliation:
University of Toronto
Michael Lishner
Affiliation:
Tel-Aviv University
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Summary

Even when confronted with life-threatening illness, patients understandably place emphasis on fertility preservation. This is compounded with the fact that a substantial proportion of patients with certain malignancies, such as testicular cancer (TC), acute lymphoblastic leukemia (ALL), and Hodgkin's lymphoma (HL) have pretreatment reproductive potential. This chapter reviews the main effects of cancer treatment on fertility and presents the contemporary approach to fertility preservation. There are several mechanisms of treatment-induced fertility impairment. Several successful pregnancies after female and male use of second generation tyrosine kinase inhibitors have recently been reported; however, there is still limited experience with imatinib drugs. Fertility preservation is an integral component of contemporary treatment plans for patients with cancer. The chapter discusses the naturally methods of fertility preservation which differ between male and females. The probability of treatment-induced fertility impairment should be weighed up against the potential side effects and efficacy of fertility preservation.

Keywords

carboplatinchemotherapyDoppler ultrasound technologypaclitaxelpregnancyovarian cancerlactationMRIsonographic scoring systems
Type
Chapter
Information
Cancer in Pregnancy and Lactation
The Motherisk Guide
 , pp. 143 - 156
Publisher: Cambridge University Press
Print publication year: 2011

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