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Chapter 73 - Transfusion

from Section 7 - Blood and Immune System

Published online by Cambridge University Press:  31 July 2019

David Chambers ,
Christopher Huang  and
Gareth Matthews
David Chambers
Affiliation:
Salford Royal NHS Foundation Trust
Christopher Huang
Affiliation:
University of Cambridge
Gareth Matthews
Affiliation:
University of Cambridge
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Summary

As discussed in Chapter 8, red blood cells (RBCs) can be thought of as ‘bags of haemoglobin’ (Hb). However, the composition of the ‘bag’ itself differs between patients. The RBCs have surface antigens that act as markers, identifying the RBC to the immune system. RBC surface antigens may be polypeptides, polysaccharides or glycoproteins. Which specific antigens are expressed is determined genetically.

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Chapter
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Basic Physiology for Anaesthetists , pp. 350 - 355
Publisher: Cambridge University Press
Print publication year: 2019

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References

Further reading

Overfield, J., Dawson, M. M., Hamer, D.. Transfusion Science, 2nd edition. Banbury, Scion, 2007.Google Scholar
Thakrar, S. V., Clevenger, B., Mallett, S.. Patient blood management and perioperative anaemia. BJA Education 2017; 17(1): 28–34.Google Scholar
Klein, A. A., Arnold, P.. Bingham, R. M., et al. AAGBI guidelines: the use of blood components and their alternatives. Anaesthesia 2016; 71(7): 829–42.Google Scholar
Orlov, D., Karkouti, K.. The pathophysiology and consequences of red blood cell storage. Anaesthesia 2015; 70(Suppl. 1): 29–37.Google Scholar
Cata, J. P., Wang, H., Gottumukkala, V., et al. Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth 2013; 110(5): 690–701.Google Scholar

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