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Transthoracic intracardiac lines provide a unique access point for postoperative monitoring and management in paediatric cardiothoracic surgeries, particularly within the single ventricle population where preserving vasculature is crucial for future interventions. This retrospective review examined paediatric single ventricle patients undergoing cardiothoracic surgeries at a tertiary children’s hospital between 2011 and 2018, focusing on the use of and factors associated with transthoracic line complications (infection, thrombosis, malfunction, and migration). A total of 338 lines were placed during the study period, with the majority occurring during palliative surgeries (86.5%). Lines remained in place for a median of 14 days postoperatively. Complications occurred in 21 lines (6.2%), comprising 8 migrations (2.4%), 7 thrombosis (2.1%), 4 malfunctions (1.2%), and 2 infections (0.6%). The presence of a surgical shunt was significantly associated with line complications (odds ratio 2.58, confidence interval 1.05 – 6.31; P 0.03). The use of transthoracic intracardiac lines seems to be safe and should be considered as a primary alternative to other central lines in the single ventricle population. A prospective assessment of transthoracic line complications, along with delineation of unit protocols, may further enhance outcomes in this complex population.
The acoustic receptivity of Tollmien–Schlichting (TS) waves due to two-dimensional sharp-edged rectangular bumps and gaps in a compressible boundary layer was investigated by direct numerical simulations. The conclusions were based on a new procedure proposed for obtaining the receptivity amplitudes which appeared to be more robust and accurate than previous ones. The procedure is particularly important for the correct evaluation of the receptivity of gaps. The receptivity amplitudes for gaps were smaller than those for bumps, except for the nominally zero height/depth roughness element, where, consistent with a linear behaviour, they had the same absolute value. The procedure also revealed in detail the behaviour in the region downstream of the roughness element where the TS wave is formed (the formation region). This region extends for approximately $50\delta ^*_{b}$, regardless of bump height or gap depth. For bumps, the receptivity scaled superlinearly with bump height while for the gaps it scaled sublinear with depth. This behaviour is associated with the different velocity profiles caused by bumps and gaps in the formation region. We also discussed issues regarding comparison with experiments. Investigation of the effect of compressibility confirmed that, in the subsonic regime, the receptivity reduces with Mach number. Finally, we addressed the receptivity scaling with the acoustic wave amplitude. It was found that the receptivity scales linearly with the acoustic wave amplitude in a range for which experiments available in the literature indicated a superlinearly scaling. Reasons for these conflicting results are discussed.
Certification marks are a type of trademark used to show that a product or service meets specific standards or qualities set by an independent organization (not by the manufacturer or seller). Certification marks could enhance the quality perception and oversight of generic drugs. Despite the FDA’s rigorous regulatory framework, skepticism about generic drug quality persists among patients and prescribers, partly due to the FDA’s limited ability to inspect manufacturing facilities. Independent certification marks — similar to USDA Organic or Energy Star labels — could help communicate drug quality information more effectively to consumers, incentivize manufacturers to exceed baseline standards, and bolster trust in generics. Such a system could operate without legislative changes and offer a cost-effective supplement to existing FDA inspections, particularly given the challenges posed by an increasingly globalized drug supply chain and current FDA resource constraints.
The Society for Healthcare Epidemiology of America, the Association of Professionals in Infection Control and Epidemiology, the Infectious Diseases Society of America, and the Pediatric Infectious Diseases Society represent the core expertise regarding healthcare infection prevention and infectious diseases and have written multisociety statement for healthcare facility leaders, regulatory agencies, payors, and patients to strengthen requirements and expectations around facility infection prevention and control (IPC) programs. Based on a systematic literature search and formal consensus process, the authors advocate raising the expectations for facility IPC programs, moving to effective programs that are:
• Foundational and influential parts of the facility’s operational structure
• Resourced with the correct expertise and leadership
• Prioritized to address all potential infectious harms
This document discusses the IPC program’s leadership—a dyad model that includes both physician and infection preventionist leaders—its reporting structure, expertise, and competencies of its members, and the roles and accountability of partnering groups within the healthcare facility. The document outlines a process for identifying minimum IPC program medical director support. It applies to all types of healthcare settings except post-acute long-term care and focuses on resources for the IPC program. Long-term acute care hospital (LTACH) staffing and antimicrobial stewardship programs will be discussed in subsequent documents.
In 1952, Erik Jarvik diagnosed and offered a brief description of the large-bodied, highly nested tristichopterid taxon Eusthenodon, and its type species E. wangsjoi, from fossils recovered from the Britta Dal Formation (Famennian) of Gauss Halvø ( = Peninsula) and Ymer Ø ( = Island) in East Greenland. The original diagnosis for Eusthenodon only needed to distinguish the tristichopterid taxon from the two others known at the time, Eusthenopteron and Tristichopterus, both of them small-bodied forms with anatomy now recognised to be primitive within the clade. Following that publication, no new large-bodied tristichopterids with Eusthenodon-like characteristics would be introduced until the description of Mandageria fairfaxi in 1997. In the 45 interim years, the limited descriptive details and insufficient diagnosis of Eusthenodon turned the name into a broadly applicable taxonomic label for large-bodied tristichopterid discoveries. Recent efforts to rediagnose the taxon and reconsider its global distribution of referred materials have improved the taxonomic utility of the name. However, no complete description of type species E. wangsjoi has yet been written. This is despite a type series of specimens that includes complete and articulated skulls that remain available for study in the collections of the Natural History Museum of Denmark (NHMD). The work presented here fulfils the need for a complete comparative description of E. wangsjoi in the context of the many highly nested tristichopterid species that have been described in the last three decades. New figures of the E. wangsjoi type series of specimens are the first to offer views of the fossils unobscured by the superimposition of interpretive line drawings. The new description is accompanied by a descriptive inventory of all the potential E. wangsjoi fossils at the NHMD and a new phylogenetic analysis of clade Tristichopteridae that includes revised character data for E. wangsjoi and adds one recently described species.
Notwithstanding their increased participation in the labour market, women across the world continue to bear family care responsibilities disproportionately, and, consequently, often find it difficult to balance effectively their dual roles as workers and caregivers. This is particularly the case for women working in the informal economy. Too often they have limited or no access to maternity protection. This situation is a potential barrier to the achievement of, among others, Sustainable Development Goals (SDG) 5 and 8, specifically target 5.c which calls for the adoption and strengthening of policies and legislation to promote gender equality as well as targets 8.5 (achievement of full and productive employment and decent work for all) and 8.8 (protection of labour rights and promotion of secure working environments for all workers, including those in precarious employment). Thus, as this Themed Collection posits, it is crucial to get a deeper understanding of obstacles to gender equality in the labour market, and the extent to which these are effectively addressed. This paper draws largely on qualitative data from recent (2022) case studies of three countries in sub-Saharan Africa—the region with the highest proportion of women working in this economy— in order to highlight some of the structural barriers to maternity protection for women in the informal economy. Particular focus is on legislative and institutional frameworks, workers’ union membership, and the financing of maternity protection. Strategic recommendations for achieving both gender equality and decent work through improved access to maternity protection conclude the paper.
It is known that the complex eigenfrequencies of one-dimensional systems of large but finite extent are concentrated near the asymptotic curve determined by the dispersion relation of an infinite system. The global instability caused by uppermost pieces of this curve was studied in various problems, including hydrodynamic stability and fluid–structure interaction problems. In this study, we generalise the equation for the asymptotic curve to arbitrary frequencies. We analyse stable local topology of the curve and prove that it can be a regular point, branching point or dead-end point of the curve. We give a classification of unstable local tolopogies, and show how they break up due to small changes of the problem parameters. The results are demonstrated on three examples: supersonic panel flutter, flutter of soft fluid-conveying pipe, and the instability of rotating flow in a pipe. We show how the elongation of the system yields the attraction of the eigenfrequencies to the asymptotic curve, and how each locally stable curve topology is reflected on the interaction of eigenfrequencies.
Given a countable group G and two subshifts X and Y over G, a continuous, shift-commuting map $\phi : X \to Y$ is called a homomorphism. Our main result states that if G is locally virtually nilpotent, X is aperiodic, and Y has the finite extension property, then there exists a homomorphism $\phi : X \to Y$. By combining this theorem with the main result of [1], we obtain that if the same conditions hold, and if additionally the topological entropy of X is less than the topological entropy of Y and Y has no global period, then X embeds into Y.
The motion and deformation of a neutrally buoyant drop in a rectangular channel experiencing a pressure-driven flow at a low Reynolds number has been investigated both experimentally and numerically. A moving-frame boundary-integral algorithm was used to simulate the drop dynamics, with a focus on steady-state drop velocity and deformation. Results are presented for drops of varying undeformed diameters relative to channel height ($D/H$), drop-to-bulk viscosity ratio ($\lambda$), capillary number ($Ca$, ratio of deforming viscous forces to shape-preserving interfacial tension) and initial position in the channel in a parameter space larger than considered previously. The general trend shows that the drop steady-state velocity decreases with increasing drop diameter and viscosity ratio but increases with increasing $Ca$. An opposite trend is seen for drops with small viscosity ratio, however, where the steady-state velocity increases with increasing $D/H$ and can exceed the maximum background flow velocity. Experimental results verify theoretical predictions. A deformable drop with a size comparable to the channel height when placed off centre migrates towards the centreline and attains a steady state there. In general, a drop with a low viscosity ratio and high capillary number experiences faster cross-stream migration. With increasing aspect ratio, there is a competition between the effect of reduced wall interactions and lower maximum channel centreline velocity at fixed average velocity, with the former helping drops attain higher steady-state velocities at low aspect ratios, but the latter takes over at aspect ratios above approximately 1.5.
This study reflects on Japan's language policy, focusing on the government‑led proposals implemented in 2006, which suggested replacing loanwords with Japanese equivalents, known as Gairaigo Iikae Teian ‘proposals for replacing loanwords’. By investigating English loanwords, this article explores the impact of English on Japanese vocabulary, while providing insights into the practical implementation of the government-led language policy in Japan for a broader global audience. It also clarifies that the objective of the proposals was not to strictly regulate the use of English loanwords but to offer suggestions, with replacement as one strategy to improve communication, especially when disseminating information through government agencies and media organisations. Through a quantitative investigation on the usage of English loanwords in the media, the results reveal that the overall number of media articles containing the loanwords in the proposed list has increased over the last 30 years. The findings also confirm that loanwords and their Japanese equivalents are not in competition, with one replacing the other. Instead, their usage exhibits a parallel trend in both frequency and increase rates.
Xinjiang’s location naturally makes it a focal point of the Silk Road (hereafter SR). But considering that for the first 60 years (circa 1920–1980) of Chinese archaeology—that is, over half of its development—the SR was rarely mentioned in scientific literature, the impact it has had on archaeological studies of Xinjiang remains unclear and poorly understood. With the eponymous Belt and Road Initiative (hereafter BRI) now a decade old and the field of Xinjiang archaeology approaching its centennial, this has become a critical subject of enquiry.
In this article, I recount the history of publication and discourse in Xinjiang, followed by a discussion of recent developments in archaeological practice instigated by the BRI. I contend that consistently using the SR to conceptualize the material record of Xinjiang, a prevalent approach in Eurasian scholarship, is based on flawed and unscientific presuppositions. Even in Chinese discourse today, the SR concept has become secondary to the state objective of building scientific and cultural infrastructure that is Chinese in method and approach, the goal of which is to amplify ‘discourse power’. Although the SR has served as a major banner for unifying studies on cross-cultural contact in Eurasian history, it is laden with complex layers of archaeological history intertwined with a century-old chauvinistic geopolitics that still reverberate globally today. As the scientific role of the SR becomes increasingly muddled, research referencing the SR must navigate the term’s biased presentist connotations to unveil the pertinent historical contexts, or consider alternative frameworks that resist totalizing narratives.
Experimental and numerical observations in turbulent shear flows point to the persistence of the anisotropy imprinted by the large-scale velocity gradient down to the smallest scales of turbulence. This is reminiscent of the strong anisotropy induced by a mean passive scalar gradient, which manifests itself by the ‘ramp–cliff’ structures. In the shear flow problem, the anisotropy can be characterised by the odd-order moments of $\partial _y u$, where $u$ is the fluctuating streamwise velocity component, and $y$ is the direction of mean shear. Here, we extend the approach proposed by Buaria et al. (Phys. Rev. Lett., 126, 034504, 2021) for the passive scalar fields, and postulate that fronts of width $\delta \sim \eta Re_\lambda ^{1/4}$, where $\eta$ is the Kolmogorov length scale, and $Re_\lambda$ is the Taylor-based Reynolds number, explain the observed small-scale anisotropy for shear flows. This model is supported by the collapse of the positive tails of the probability density functions (PDFs) of $(\partial _y u)/(u^{\prime }/\delta )$ in turbulent homogeneous shear flows (THSF) when the PDFs are normalised by $\delta /L$, where $u^{\prime }$ is the root-mean-square of $u$ and $L$ is the integral length scale. The predictions of this model for the odd-order moments of $\partial _y u$ in THSF agree well with direct numerical simulation (DNS) and experimental results. Moreover, the extension of our analysis to the log-layer of turbulent channel flows (TCF) leads to the prediction that the odd-order moments of order $p (p \gt 1)$ of $\partial _y u$ have power-law dependencies on the wall distance $y^{+}$: $\langle (\partial _y u)^p \rangle /\langle (\partial _y u)^2 \rangle ^{p/2} \sim (y^{+})^{(p-5)/8}$, which is consistent with DNS results.
Given a fixed k-uniform hypergraph F, the F-removal lemma states that every hypergraph with few copies of F can be made F-free by the removal of few edges. Unfortunately, for general F, the constants involved are given by incredibly fast-growing Ackermann-type functions. It is thus natural to ask for which F one can prove removal lemmas with polynomial bounds. One trivial case where such bounds can be obtained is when F is k-partite. Alon proved that when $k=2$ (i.e. when dealing with graphs), only bipartite graphs have a polynomial removal lemma. Kohayakawa, Nagle and Rödl conjectured in 2002 that Alon’s result can be extended to all $k\gt2$, namely, that the only $k$-graphs $F$ for which the hypergraph removal lemma has polynomial bounds are the trivial cases when F is k-partite. In this paper we prove this conjecture.
If Paris was known as the capital of the nineteenth century, recent trends in musicology have encouraged some to turn their eyes away from this position in search of new scholarly frameworks. Many researchers have, on the one hand, moved away from capital-city studies and placed renewed emphasis on excavating the diverse regional cultural environments to fully account for a national musical landscape, in France and beyond.1 On the other hand, opera scholars in particular have championed a transnational approach to mapping performers’ careers, the circulation of repertoire, and the development of singing and staging practices.2 Neither approach entirely forsakes the capital, in fact, especially in the case of France. Rather, the highly centralized nature of nineteenth-century French cultural infrastructure has ensured that one of the tantalizing results of shifting the scholarly lens to different geographies is the revelation of new aspects of the significance of the capital’s musical practices when placed in relationship with others, and the parallel interrogation of the scope and source of Paris’s status and influence when inserted within a broader network.3 In other words, recent directions in French music history, in allowing for a more critical assessment of the place and function of the capital from new perspectives, still ignite rather than dim the lure of the musical context of Paris sui generis. Indeed, the monographs reviewed in this article highlight that this is for good reason. These three nineteenth-century studies unveil a multiplicity of the capital’s musical practices, sites, and figures that, just like new geographies, remain unfamiliar to musicologists despite the ubiquity of the capital in scholars’ eyes, and cast new light on Parisian musical history.
We define ‘surface layer’ (SL) as an inertia-dominated turbulence region outside a viscous or roughness surface-adjacent sub-layer (SAS) that is characterised by linear scaling of specific coherence length scales on wall-normal distance, $z$. We generalise the mechanisms that underlie the formation of the classical inertial SL in the shear-dominated turbulent boundary layer (TBL) to wall-bounded turbulent flows with zero mean shear. Using particle image velocimetry data from two wind tunnel facilities, we contrast the classical TBL SL with a non-classical shear-free SL generated within grid turbulence advected over an impermeable plate using two grids with different turbulence length scales. Integral-scale variations with $z$ and other statistics are quantified. In both shear-dominated and shear-free SLs we observe well-defined linear increases in $z$ of the streamwise integral scale of vertical velocity fluctuations. In grid turbulence the shear-free SL initiates just above the SAS that confines friction-generated motions. By contrast, the TBL SL forms with non-zero mean shear rate that extends streamwise coherence lengths of streamwise fluctuations. In both flow classes only the integral scales of vertical fluctuating velocity increase linearly with $z$, indicating that the SL is generated by the blockage of vertical fluctuations in the vertical. Whereas the SAS in the TBL is much thinner than in the grid-turbulence flows, the generation of a shear-free SL by the interaction of turbulence eddies and a surface depends on the relative thinness of the SAS. We conclude that the common generalisable SL mechanism is direct blockage of vertical fluctuations by the impermeable surface.
Significant progress has been made in understanding planetary core dynamics using numerical models of rotating convection (RC) in spherical shell geometry. However, the behaviour of forces in these models within various dynamic regimes of RC remains largely unknown. Directional anisotropy, scale dependence and the role of dynamically irrelevant gradient contributions in incompressible flows complicate the representation of dynamical balances in spherical shell RC. In this study, we systematically compare integrated and scale-dependent representations of mean and fluctuation forces and curled forces (which contain no gradient contributions) separately for the three components ($\hat {r},\hat {\theta },\hat {\phi }$). The analysis is performed with simulations in a range of convective supercriticality $Ra_T/Ra_T^{c}=1.2{-}297$ where $Ra_T$ and $Ra^{c}_T$ are the Rayleigh and critical Rayleigh numbers, respectively and Ekman number $E=10^{-3}{-}10^{-6}$, with fixed Prandtl number $Pr=1$, along with no-slip and fixed flux boundaries. We have excluded regions from each boundary of the spherical shell, with a thickness equivalent to ten velocity boundary layers, which provides a consistent representation of the bulk dynamics between the volume-averaged force and curled force balance in the parameter space studied. Radial, azimuthal and co-latitudinal components exhibit distinct force and curled force balances. The total magnitudes of the mean forces and mean curled forces exhibit a primary thermal wind balance; the corresponding fluctuating forces are in a quasi-geostrophic primary balance, while the fluctuating curled forces transition from a Viscous–Archimedean–Coriolis balance to an Inertia–Viscous–Archimedean–Coriolis balance with increasing $Ra_T/Ra_T^{c}$. The curled force balances are more weakly scale-dependent compared to the forces, and do not show clear cross-over length scales. The fluctuating force and curled force balances are broadly consistent with three regimes of RC (weakly nonlinear, rapidly rotating and weakly rotating), but do not exhibit sharp changes with $Ra_{T}/Ra_{T}^{c}$, which inhibits the identification of precise regime boundaries from these balances.