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Chapter 14 - Pregnancy Complications and Children Outcomes in Patients with Polycystic Ovarian Syndrome

Published online by Cambridge University Press:  13 May 2022

By
Femi Janse  and
Bart C. J. M. Fauser
Edited by
Gabor T. Kovacs ,
Bart Fauser  and
Richard S. Legro
Gabor T. Kovacs
Affiliation:
Monash University, Melbourne, Australia
Bart Fauser
Affiliation:
University Medical Center, Utrecht, Netherlands
Richard S. Legro
Affiliation:
Penn State Medical Center, Hershey, PA, USA
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Summary

Polycystic ovary syndrome (PCOS) is a notoriously heterogeneous, common reproductive disorder associated with many coexisting conditions, including hyperandrogenemia, obesity, insulin resistance and other signs of metabolic dysfunction. PCOS is often diagnosed in the context of anovulatory infertility. However, more recent research disclosed an association of PCOS with increased chances for pregnancy complications, adverse perinatal outcomes and suboptimal long-term health of children born to women with PCOS. This chapter provides an overview of current literature concerning obstetrical complications in women with PCOS, especially increased risk for gestational diabetes (OR 2.7–2.9), hypertensive disorders of pregnancy (including preeclampsia, OR 1.9–4.2) and preterm birth (OR 1.5–2.2). In addition, information regarding children’s outcomes is provided, including birth weight, cardiovascular health and neurodevelopmental health. Finally, pathological pathways including biomarker data in pregnancy and placenta morphology are discussed.

Keywords

polycystic ovary syndrome (PCOS)pregnancy complicationsobstetricsperinatal outcomesoffspringchildrengestational diabetes
Type
Chapter
Information
Polycystic Ovary Syndrome , pp. 131 - 141
Publisher: Cambridge University Press
Print publication year: 2022

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References

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