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For
from Section VI - Male-factor Infertility
Published online by Cambridge University Press: 25 November 2021
For over a decade it has been abundantly clear that a semen analysis is unfit for purpose Is it ethical to continue using outdated semen analysis tools that result in a useless diagnosis of idiopathic infertility in 30% of men? Data from the four sperm DNA tests is not interchangeable Only the Comet is a quantitative test measuring the damage in individual sperm There is a strong correlation between sperm DNA quality and both IVF and ICSI live births using the Comet assay. High DNA damage (high Comet score) is just as important as female age Sperm DNA damage is significantly correlated with an increased risk of sporadic and recurrent miscarriages following natural conceptions and following both IVF and ICSI Double strand breaks may be more predictive for treatment failure than single strand breaks
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