Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2025-01-01T14:57:09.182Z Has data issue: false hasContentIssue false

42A - Pituitary Suppression Using GnRH Agonist for IVF Is Outdated

For

from Section VIII - Ovarian Stimulation

Published online by Cambridge University Press:  25 November 2021

By
Efstratios Kolibianakis
Edited by
Roy Homburg ,
Adam H. Balen  and
Robert F. Casper
Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
Get access

Summary

An equal probability of live birth to GnRH agonists, combined with a vastly superior safety and patient friendly profile, allows us beyond doubt to recognise that GnRH antagonist is the analogue of first choice in ovarian stimulation for IVF. Τhe use of GnRH antagonists in everyday practice shows an impressive and clear trend for replacing GnRH agonists as the analogue of choice for suppressing the premature LH rise, essentially leading to the end of the GnRH agonist era.

Type
Chapter
Information
50 Big Debates in Reproductive Medicine , pp. 216 - 218
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Al-Inany, HG, Youssef, MA, Aboulghar, M, et al. Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev. 2011;CD001750.CrossRefGoogle Scholar
Tarlatzis, B, Bosdou, J. Elimination of OHSS by GnRH agonist and freezing embryos. In: Rizk, B, Gerris, J (eds). Complications and Outcomes of Assisted Reproduction. Cambridge: Cambridge University Press, 2017, pp. 149–63.Google Scholar
Bosdou, JK, Venetis, CA, Tarlatzis, BC, et al. Higher probability of live-birth in high, but not normal, responders after first frozen-embryo transfer in a freeze-only cycle strategy compared to fresh-embryo transfer: a meta-analysis. Hum Reprod. 2019;34:491–505.CrossRefGoogle ScholarPubMed
Lambalk, CB, Banga, FR, Huirne, JA, et al. GnRH antagonist versus long agonist protocols in IVF: a systematic review and meta-analysis accounting for patient type. Hum Reprod Update. 2017;23:560–5.CrossRefGoogle ScholarPubMed
Kolibianakis, EM, Griesinger, G, Venetis, CA. GnRH antagonists vs. long GnRH agonists in IVF: significant flaws in a meta-analysis lead to invalid conclusions. Hum Reprod Update. 2018;24:242–3.CrossRefGoogle Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×