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from Section VIII - Ovarian Stimulation
Published online by Cambridge University Press: 25 November 2021
The objective of ovarian stimulation in an IVF cycle is the production of between 5 and 15 oocytes, avoiding both a poor and a hyper-response which are generally associated with worse outcomes for the patient. In women predicted to have a low response, it has become common practice to increase the daily FSH dose to 300 IU or above, in order to increase the oocyte yield, and achieve a normal response. While evidence from randomised trials demonstrates that higher doses tend to result in fewer cycle cancellations and a higher oocyte yield, there is no evidence that these effects translate to an improvement in the pregnancy and live birth rates. Given that increased FSH dosing is associated with higher costs, increasing the dose beyond 300 IU is not recommended.
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