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43B - The Maximum Effective Dose of FSH for Ovarian Stimulation in IVF Is 300 IU

Against

from Section VIII - Ovarian Stimulation

Published online by Cambridge University Press:  25 November 2021

By
Georgios Lainas
Edited by
Roy Homburg ,
Adam H. Balen  and
Robert F. Casper
Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

There is evidence to suggest that higher gonadotropin dose might be associated with higher number of oocytes retrieved. The potential association of the higher number of oocytes and cumulative live birth rates, in particular in poor responders, needs to be further investigated in well-designed randomised trials. Nevertheless, the gonadotropin regimen should be administered with caution, taking into account patient safety and efficacy, until further evidence could justify the use of higher gonadotropin dose during ovarian stimulation in poor responders.

Type
Chapter
Information
50 Big Debates in Reproductive Medicine , pp. 225 - 227
Publisher: Cambridge University Press
Print publication year: 2021

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References

van Tilborg, TC, Torrance, HI, Oudshoorn, SC, et al. Individualized versus standard FSH dosing in women starting IVF/ICSI: an RCT. Part 1: the predicted poor responder. Hum Reprod. 2017;32:2496–505.CrossRefGoogle ScholarPubMed
Lensen, SF, Wilkinson, J, Leijdekkers, JA, et al. Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI). Cochrane Database Syst Rev. 2018;2:CD012693.Google ScholarPubMed
Polyzos, NP, Drakopoulos, P, Parra, J, et al. Cumulative live birth rates according to the number of oocytes retrieved after the first ovarian stimulation for in vitro fertilization/intracytoplasmic sperm injection: a multicenter multinational analysis including approximately 15,000 women. Fertil Steril. 2018;110:661–70.e661.CrossRefGoogle Scholar
Wong, KM, van Wely, M, Moi, F, et al. Fresh versus frozen embryo transfers in assisted reproduction. Cochrane Database Syst Rev. 2017;3:CD011184.Google ScholarPubMed
Oudshoorn, SC, van Tilborg, TC, Eijkemans, MJC, et al. Individualized versus standard FSH dosing in women starting IVF/ICSI: an RCT. Part 2: the predicted hyper responder. Hum Reprod. 2017;32:2506–14.CrossRefGoogle ScholarPubMed
Labarta, E, Bosch, E, Alama, P, et al. Moderate ovarian stimulation does not increase the incidence of human embryo chromosomal abnormalities in in vitro fertilization cycles. J Clin Endocrinol Metab. 2012;97:E1987–94.CrossRefGoogle Scholar

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