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1B - Female Age 42 Years Should Be the Upper Limit for Conventional IVF/ICSI Treatment

Against

from Section I - Limits for IVF

Published online by Cambridge University Press:  25 November 2021

By
Tim Child
Edited by
Roy Homburg ,
Adam H. Balen  and
Robert F. Casper
Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

I was delighted when asked to write against the proposal to deny women aged 42 years or more the chance of their own genetic motherhood. Indeed, it is challenging to imagine the points that my opposing author will use to try and limit a woman’s reproductive choice! To debate the matter we need to 1) examine the IVF/ICSI livebirth rate for women in their 40s, 2) consider the risks to the health of these mothers and their baby(ies) and what can be done to mitigate any concerns, and 3) contemplate the grounds for denying such treatment, and the offered alternatives (childlessness?).

Type
Chapter
Information
50 Big Debates in Reproductive Medicine , pp. 5 - 7
Publisher: Cambridge University Press
Print publication year: 2021

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References

Gunnala, V, Irani, M, Melnick, A, Rosenwaks, Z, Spandorfer, S. One thousand seventy-eight autologous IVF cycles in women 45 years and older: the largest single-center cohort to date. J Assist Reprod Genet. 2018;35(3):435–40.CrossRefGoogle ScholarPubMed
Ubaldi, FM, Cimadomo, D, Capalbo, A, et al. Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience. Fertil Steril. 2017;107(5):1173–80.CrossRefGoogle Scholar
Sydsjö, G, Lindell Pettersson, M, Bladh, M, Skoog Svanberg, A, Lampic, C, Nedstrand, E. Evaluation of risk factors’ importance on adverse pregnancy and neonatal outcomes in women aged 40 years or older. BMC Pregnancy Childbirth. 2019;19(1):92.CrossRefGoogle ScholarPubMed
American College of Obstetricians and Gynecologists. Prepregnancy counselling. ACOG Committee Opinion No. 762. Obstet Gynecol. 2019;133:e78–9.Google Scholar
Savasi, VM, Mandia, L, Laoreti, A, Cetin, I. Maternal and fetal outcomes in oocyte donation pregnancies. Hum Reprod Update. 2016;22(5):620–33.CrossRefGoogle ScholarPubMed

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