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41B - AMH Is a Better Predictor of Ovarian Response Than AFC

Against

from Section VIII - Ovarian Stimulation

Published online by Cambridge University Press:  25 November 2021

By
Frank Broekmans
Edited by
Roy Homburg ,
Adam H. Balen  and
Robert F. Casper
Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

Ovarian response prediction may be advantageous if the predicted response may be prevented or the inherent risks may be managed. In ART today, high/excessive response is the only condition to predict as OHSS prevention may be improved by prior knowledge of this risk condition. The scientific literature on the AFC and serum AMH, markers of the number of FSH responsive antral follicles, demonstrates equal accuracy. AMH- and AFC-based individualised FSH dosing studies have revealed equal effects on safety outcome measures compared to standard dosing. However, with the preference for antagonist cycles, OHSS preventive management is well possible without any prior ovarian response testing, making both tests equally futile.

Type
Chapter
Information
50 Big Debates in Reproductive Medicine , pp. 212 - 215
Publisher: Cambridge University Press
Print publication year: 2021

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References

Broer, SL, van Disseldorp, J, Broeze, KA, et al. Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach. Hum Reprod Update. 2013;19(1): 26–36.CrossRefGoogle ScholarPubMed
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Lan, VT, Linh, NK, Tuong, HM, Wong, PC, Howles, CM. Anti-mullerian hormone versus antral follicle count for defining the starting dose of FSH. Reprod Biomed Online. 2013;27(4): 390–9.CrossRefGoogle ScholarPubMed
Magnusson, A, Nilsson, L, Olerod, G, Thurin-Kjellberg, A, Bergh, C. The addition of anti-mullerian hormone in an algorithm for individualized hormone dosage did not improve the prediction of ovarian response – a randomized, controlled trial. Hum Reprod. 2017;32(4): 811–19.CrossRefGoogle Scholar
Lensen, SF, Wilkinson, J, Leijdekkers, JA, et al. Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI). Cochrane Database Syst Rev. 2018;2018(2).Google Scholar
Leijdekkers, JA, Eijkemans, MJC, van Tilborg, TC, et al. Cumulative live birth rates in low-prognosis women. Hum Reprod. 2019;34(6): 1030–41.CrossRefGoogle ScholarPubMed

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