A two-element textile antenna with high isolation and polarization diversity is presented for 5 G communications, wearable technology and biomedical cancer detection applications. The flexible material is used with an orthogonally placed microstrip-feed radiator antenna responsible for polarization diversity. High isolation and low correlation are achieved between antenna elements with defected ground-based on diagonal and open-stubs, which perturbs the surface current and facilitates the achievement of circular polarization. The 10 dB impedance bandwidth (|S11|) of a two-element antenna varies from 3.3 to 4.3 GHz with more than 24 dB isolation (|S21|). The envelope correlation coefficient (ECC) and channel capacity loss (CCL) of multi-input and multi-output (MIMO) antenna parameters are less than 0.2 and 0.35 bits/s/Hz respectively, which validates the diversity performance of the antenna.